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Article

Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children

  • Authors:
    • Xue Han
    • Jianjun Xiu
    • Zhaoqin Huang
    • Jie Zhang
    • Zhonghe  Zhang
    • Yin Dong
    • Xianshun Yuan
    • Qingwei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Shandong Provincial Hospital of Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 551-556
    |
    Published online on: June 11, 2014
       https://doi.org/10.3892/etm.2014.1778
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Abstract

The aim of the present study was to obtain standard reference values for the pituitary gland volumes of healthy children and to analyze the potential diagnostic values of pituitary gland volumetry for growth hormone deficiency (GHD) and idiopathic short stature (ISS). The volume of the pituitary gland was measured using a thin‑section three‑dimensional (3D) magnetic resonance imaging (MRI) sequence of magnetization‑prepared rapid gradient echo imaging with a section thickness of 1 mm. A group of 75 healthy children aged between 1 and 19 years were recruited to obtain normal volumetry values of the pituitary gland. These individuals demonstrated no evidence of abnormalities to the central nervous or endocrine systems prior to the study. An additional group of 55 children with GHD (n=32) or ISS (n=23) aged between 0 and 14 years were included in the measurement of pituitary gland volume and height. The Student's t‑test was used to evaluate the repetition test, while Pearson's correlation coefficient and regression analyses were performed to examine the correlations between the volume and height of the pituitary glands. Pituitary gland volume and height demonstrated an increasing trend with age in the healthy children. In addition, the pituitary gland volume exhibited a growth spurt in the early teenage years (10‑14 years‑old), which was more prominent in females. The growth spurt was not observed for pituitary gland height. When compared with the healthy children, 65.6% of the children with GHD and 34.8% of the children with ISS had smaller pituitary gland volumes. Similarly, 37.5% of the children with GHD and 26.1% of the children with ISS had a smaller pituitary gland height compared with the healthy children. The pituitary gland volume performed significantly better compared with height with regard to the detection rate. Therefore, the results indicated that 3D MRI volumetry was useful for understanding the developmental characteristics of the pituitary gland in healthy children, and that the reference data provided by 3D MRI were effective in the diagnosis of short stature following associations with neuroimaging and clinical functional abnormalities of the pituitary gland.
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Copy and paste a formatted citation
Spandidos Publications style
Han X, Xiu J, Huang Z, Zhang J, Zhang Z, Dong Y, Yuan X and Liu Q: Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children. Exp Ther Med 8: 551-556, 2014.
APA
Han, X., Xiu, J., Huang, Z., Zhang, J., Zhang, Z., Dong, Y. ... Liu, Q. (2014). Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children. Experimental and Therapeutic Medicine, 8, 551-556. https://doi.org/10.3892/etm.2014.1778
MLA
Han, X., Xiu, J., Huang, Z., Zhang, J., Zhang, Z., Dong, Y., Yuan, X., Liu, Q."Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children". Experimental and Therapeutic Medicine 8.2 (2014): 551-556.
Chicago
Han, X., Xiu, J., Huang, Z., Zhang, J., Zhang, Z., Dong, Y., Yuan, X., Liu, Q."Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children". Experimental and Therapeutic Medicine 8, no. 2 (2014): 551-556. https://doi.org/10.3892/etm.2014.1778
Copy and paste a formatted citation
x
Spandidos Publications style
Han X, Xiu J, Huang Z, Zhang J, Zhang Z, Dong Y, Yuan X and Liu Q: Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children. Exp Ther Med 8: 551-556, 2014.
APA
Han, X., Xiu, J., Huang, Z., Zhang, J., Zhang, Z., Dong, Y. ... Liu, Q. (2014). Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children. Experimental and Therapeutic Medicine, 8, 551-556. https://doi.org/10.3892/etm.2014.1778
MLA
Han, X., Xiu, J., Huang, Z., Zhang, J., Zhang, Z., Dong, Y., Yuan, X., Liu, Q."Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children". Experimental and Therapeutic Medicine 8.2 (2014): 551-556.
Chicago
Han, X., Xiu, J., Huang, Z., Zhang, J., Zhang, Z., Dong, Y., Yuan, X., Liu, Q."Three‑dimensional magnetic resonance volumetry of the pituitary gland is effective in detecting short stature in children". Experimental and Therapeutic Medicine 8, no. 2 (2014): 551-556. https://doi.org/10.3892/etm.2014.1778
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