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Article

Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits

  • Authors:
    • Yang Xiao
    • Lai‑Lai Li
    • Yan‑Yan Wang
    • Jing‑Jing Guo
    • Wen‑Ping Xu
    • Yi Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China
  • Pages: 968-972
    |
    Published online on: June 20, 2014
       https://doi.org/10.3892/etm.2014.1794
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Abstract

This study investigated the effects of naringin on platelet aggregation and release in hyperlipidemic rabbits, and the underlying mechanisms. The safety of naringin was also investigated. The rabbits were orally administered 60, 30 or 15 mg/kg of naringin once a day for 14 days after being fed a high fat/cholesterol diet for four weeks. Following the two weeks of drug administration, the degree of platelet aggregation induced by arachidonic acid, adenosine diphosphate and collagen was significantly reduced by naringin at certain doses compared with those in the rabbits of the model group (P<0.01). The levels of P‑selectin and platelet factor 4 (PF4) also decreased following treatment with naringin compared with those of the model group. Certain doses of naringin significantly reduced the total cholesterol (TC) levels and elevated the ratio of high‑density lipoprotein cholesterol to TC compared with those in the model group, and significantly decreased the cytosolic free calcium concentration ([Ca2+]i). No significant difference in the coagulation function was observed between the control and drug‑treatment groups. These results indicate that naringin improved platelet aggregation and inhibited the excessive release of P‑selectin and PF4 in hyperlipidemic rabbits. This study suggests that the antiplatelet effect of naringin may be due to its ability to regulate the levels of blood cholesterol and [Ca2+]i in platelets. Naringin also did not cause bleeding in the hyperlipidemic rabbits.
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1 

Jennings LK: Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost. 102:248–257. 2009.PubMed/NCBI

2 

De Meyer SF, Vanhoorelbeke K, Broos K, Salles II and Deckmyn H: Antiplatelet drugs. Br J Haematol. 142:515–528. 2008.

3 

Siller-Matula JM, Krumphuber J and Jilma B: Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases. Br J Pharmacol. 159:502–517. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 324:71–86. 2002. View Article : Google Scholar

5 

Speich HE, Earhart AD, Hill SN, et al: Variability of platelet aggregate dispersal with glycoprotein IIb-IIIa antagonists eptifibatide and abciximab. J Thromb Haemost. 7:983–991. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Cannon CP, Rhee KE, Califf RM, et al: REACH Registry Investigators: Current use of aspirin and antithrombotic agents in the United States among outpatients with atherothrombotic disease (from the REduction of Atherothrombosis for Continued Health [REACH] Registry). Am J Cardiol. 105:445–452. 2010.PubMed/NCBI

7 

Wang Y, Wang J, Guo L and Gao X: Antiplatelet effects of Qishen Yiqi Dropping Pill in platelets aggregation in hyperlipidemic rabbits. Evid Based Complement Alternat Med. 2012:2054512012.PubMed/NCBI

8 

Zhang Y, Tang Y, Guo J, et al: Dose-effect relationship of traditional Chinese medicine formula for promoting blood circulation to remove stasis on ADP-induced platelet aggregation and rabbit plasma thrombin time. Zhongguo Zhong Yao Za Zhi. 34:2821–2826. 2009.(In Chinese).

9 

Kang SR, Park KI, Park HS, et al: Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantim L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways. Food Chem. 129:1721–1728. 2011.

10 

Jagetia GC and Reddy TK: Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. Chem Biol Interact. 190:121–128. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Kanno S, Shouji A, Tomizawa A, et al: Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. Life Sci. 78:673–681. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Balestrieri ML, Castaldo D, Balestrieri C, et al: Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. J Lipid Res. 44:380–387. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Gorinstein S, Leontowicz H and Leontowicz M: Effect of hesperidin and naringin on the plasma lipid profile and plasma antioxidant activity in rats fed a cholesterol-containing diet. J Sci Food Agric. 87:1257–1262. 2007. View Article : Google Scholar

14 

Jeon SM, Bok SH, Jang MK, et al: Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci. 69:2855–2866. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Singh D, Chander V and Chopra K: Protective effect of naringin, a bioflavonoid on glycerol-induced acute renal failure in rat kidney. Toxicology. 201:143–151. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Born GV and Cross MJ: The aggregation of blood platelets. J Physiol. 168:178–195. 1963. View Article : Google Scholar

17 

Sener A, Ozasvci D, Oba R, et al: Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet-leukocyte aggregate formation occur simultaneously in hyperlipidemia? Clin Biochem. 38:1081–1087. 2005. View Article : Google Scholar

18 

Pei W, Baron H, Müller-Myhsok B, et al: Support for linkage of familial combined hyperlipidemia to chromosome 1q21–q23 in Chinese and German families. Clin Genet. 57:29–34. 2000.

19 

Ghaffari MA and Ghiasvand T: In vitro effect of Naringin and Quercetin on LDL oxidation via their influence in copper binding to LDL. Iranian Journal of Diabetes and Lipid Disorders. 7:23–33. 2007.(In Persian).

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Copy and paste a formatted citation
Spandidos Publications style
Xiao Y, Li LL, Wang YY, Guo JJ, Xu WP and Wang Y: Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits. Exp Ther Med 8: 968-972, 2014.
APA
Xiao, Y., Li, L., Wang, Y., Guo, J., Xu, W., & Wang, Y. (2014). Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits. Experimental and Therapeutic Medicine, 8, 968-972. https://doi.org/10.3892/etm.2014.1794
MLA
Xiao, Y., Li, L., Wang, Y., Guo, J., Xu, W., Wang, Y."Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits". Experimental and Therapeutic Medicine 8.3 (2014): 968-972.
Chicago
Xiao, Y., Li, L., Wang, Y., Guo, J., Xu, W., Wang, Y."Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits". Experimental and Therapeutic Medicine 8, no. 3 (2014): 968-972. https://doi.org/10.3892/etm.2014.1794
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Y, Li LL, Wang YY, Guo JJ, Xu WP and Wang Y: Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits. Exp Ther Med 8: 968-972, 2014.
APA
Xiao, Y., Li, L., Wang, Y., Guo, J., Xu, W., & Wang, Y. (2014). Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits. Experimental and Therapeutic Medicine, 8, 968-972. https://doi.org/10.3892/etm.2014.1794
MLA
Xiao, Y., Li, L., Wang, Y., Guo, J., Xu, W., Wang, Y."Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits". Experimental and Therapeutic Medicine 8.3 (2014): 968-972.
Chicago
Xiao, Y., Li, L., Wang, Y., Guo, J., Xu, W., Wang, Y."Naringin administration inhibits platelet aggregation and release by reducing blood cholesterol levels and the cytosolic free calcium concentration in hyperlipidemic rabbits". Experimental and Therapeutic Medicine 8, no. 3 (2014): 968-972. https://doi.org/10.3892/etm.2014.1794
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