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Article

Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver

  • Authors:
    • Minoru Tomizawa
    • Yuji Kawanabe
    • Fuminobu Shinozaki
    • Sumihiko Sato
    • Yasufumi Motoyoshi
    • Takao Sugiyama
    • Shigenori Yamamoto
    • Makoto Sueishi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaidō, Chiba 284‑0003, Japan, Sato Clinic, Wakaba‑ku, Chiba, Chiba 264‑0021, Japan, Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaidō, Chiba 284‑0003, Japan, Department of Neurology, National Hospital Organization Shimoshizu Hospital, Yotsukaidō, Chiba 284‑0003, Japan, Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaidō, Chiba 284‑0003, Japan, Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaidō, Chiba 284‑0003, Japan
  • Pages: 759-762
    |
    Published online on: June 23, 2014
       https://doi.org/10.3892/etm.2014.1798
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Abstract

In the present study, the threshold values of laboratory data for the diagnosis of non‑alcoholic fatty liver disease (NAFLD) were investigated. The study enrolled patients who had undergone abdominal ultrasound (US) between April 2013 and August 2013, and for whom laboratory data were available on the same day. NAFLD was diagnosed following observations of a bright liver or hepatorenal echo contrast on the abdominal US scans. Patients were excluded from the study if they had liver diseases or had been prescribed prednisolone or methotrexate. Receiver operating characteristic curves, the Wilcoxon signed‑rank test and Fisher's exact probability test were used for data analysis. In total, 80 NAFLD and 94 non‑NAFLD patients were enrolled in the study. The threshold levels of alanine aminotransferase (ALT) and triglyceride (TG) for the diagnosis of NAFLD were 19.0 IU/l and 101 mg/dl, respectively. Patients were divided into two groups according to the levels of ALT and TG. Those with ALT levels of >19 IU/l and TG levels of >101 mg/dl were defined as the positive group, while the remaining patients were classified as the negative group. The specificity and positive predictive value using the combined threshold levels of ALT >19 IU/l and TG >101 mg/dl were 80.9 and 75.0%, respectively. Therefore, the results indicated that ALT levels of >19 IU/l or TG levels of >101 mg/dl were useful markers for the screening of NAFLD. However, NAFLD was more strongly suspected in patients with ALT levels of >19 IU/l and TG levels of >101 mg/dl.
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Copy and paste a formatted citation
Spandidos Publications style
Tomizawa M, Kawanabe Y, Shinozaki F, Sato S, Motoyoshi Y, Sugiyama T, Yamamoto S and Sueishi M: Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver. Exp Ther Med 8: 759-762, 2014.
APA
Tomizawa, M., Kawanabe, Y., Shinozaki, F., Sato, S., Motoyoshi, Y., Sugiyama, T. ... Sueishi, M. (2014). Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver. Experimental and Therapeutic Medicine, 8, 759-762. https://doi.org/10.3892/etm.2014.1798
MLA
Tomizawa, M., Kawanabe, Y., Shinozaki, F., Sato, S., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Sueishi, M."Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver". Experimental and Therapeutic Medicine 8.3 (2014): 759-762.
Chicago
Tomizawa, M., Kawanabe, Y., Shinozaki, F., Sato, S., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Sueishi, M."Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver". Experimental and Therapeutic Medicine 8, no. 3 (2014): 759-762. https://doi.org/10.3892/etm.2014.1798
Copy and paste a formatted citation
x
Spandidos Publications style
Tomizawa M, Kawanabe Y, Shinozaki F, Sato S, Motoyoshi Y, Sugiyama T, Yamamoto S and Sueishi M: Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver. Exp Ther Med 8: 759-762, 2014.
APA
Tomizawa, M., Kawanabe, Y., Shinozaki, F., Sato, S., Motoyoshi, Y., Sugiyama, T. ... Sueishi, M. (2014). Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver. Experimental and Therapeutic Medicine, 8, 759-762. https://doi.org/10.3892/etm.2014.1798
MLA
Tomizawa, M., Kawanabe, Y., Shinozaki, F., Sato, S., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Sueishi, M."Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver". Experimental and Therapeutic Medicine 8.3 (2014): 759-762.
Chicago
Tomizawa, M., Kawanabe, Y., Shinozaki, F., Sato, S., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Sueishi, M."Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver". Experimental and Therapeutic Medicine 8, no. 3 (2014): 759-762. https://doi.org/10.3892/etm.2014.1798
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