Characteristics and risk factor analysis of 410 cases of tracheobronchial tuberculosis

Guo,Xinmei; Wang,Chunyan; Wang,Xiaoping; Ma,Juan; Xv,Li; Luan,Tingting; Kou,Changwei

doi:10.3892/etm.2014.1804

September-2014 Volume 8 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-2014 Volume 8 Issue 3

Full Size Image

Article

Characteristics and risk factor analysis of 410 cases of tracheobronchial tuberculosis

Authors:
- Xinmei Guo
- Chunyan Wang
- Xiaoping Wang
- Juan Ma
- Li Xv
- Tingting Luan
- Changwei Kou
View Affiliations / Copyright

Affiliations: Tuberculosis Division, Shandong Chest Hospital, Jinan, Shandong 250013, P.R. China
Pages: 781-784
|
Published online on: June 24, 2014

https://doi.org/10.3892/etm.2014.1804
Expand metrics +

Abstract

The present study analyzed the characteristics and risk factors associated with tracheobronchial tuberculosis (TBTB) in 410 patients with TBTB. Retrospective analysis was performed on the clinical features, bronchoscopy performance, bacteriological examination, imaging and treatment of 410 patients who were diagnosed with TBTB using bronchoscopy. Among the 410 patients, 10 patients underwent chest X‑ray which revealed two cases of atelectasis, eight cases of patch or spot shadows, three cases of cavity, one case of nodule and one case with no abnormalities. The remaining 400 patients underwent computed tomography chest scans and/or airway reconstruction examinations. Among all the lesion types, the cavity type was found to be the most likely to cause bronchial stenosis or obstruction, with statistically significant differences when compared with the congestion, stenosis or scar lesion types (P<0.01). Moreover, for the cavity type, there were 194 sites of obstruction prior to therapy; however, only 23 sites of obstruction remained following therapy. Furthermore, there were 34 sites without stenosis prior to therapy and 205 sites without stenosis following therapy. The number of sites of obstruction was significantly decreased and the number of sites without stenosis was increased upon therapy. These findings suggest that the cavity type is the most sensitive type to therapy among the five types of TBTB lesion.

View Figures

View References

1	Chung HS and Lee JH: Bronchoscopic assessment of the evolution of endobronchial tuberculosis. Chest. 117:385–392. 2000. View Article : Google Scholar : PubMed/NCBI
2	Wang WB, Zhao Q, Yuan ZA, Jiang WL, Liu ML and Xu B: Deaths of tuberculosis patients in urban China: a retrospective cohort study. Int J Tuberc Lung Dis. 17:493–498. 2013. View Article : Google Scholar : PubMed/NCBI
3	Chinese Medical Association Tuberculosis Branch; Editorial Board of The Journal of Tuberculosis and Respiratory Disease. Tracheobronchial tuberculosis diagnosis and treatment guidelines (Trial). Chinese Journal of Tuberculosis and Respiratory Diseases. 35:581–587. 2012.(In Chinese).
4	Ehrlich RI, Adams S, Baatjies R and Jeebhay MF: Chronic airflow obstruction and respiratory symptoms following tuberculosis: a review of South African studies. Int J Tuberc Lung Dis. 15:886–891. 2011. View Article : Google Scholar : PubMed/NCBI
5	Watanabe A: Clinical manifestation of Q fever and tuberculosis, similarly caused by intracellular parasites. Kekkaku. 81:543–549. 2006.(In Japanese).
6	Kashyap S, Mohapatra PR and Saini V: Endobronchial tuberculosis. Indian J Chest Dis Allied Sci. 45:247–256. 2003.
7	Xue Q, Wang N, Xue X and Wang J: Endobronchial tuberculosis: an overview. Eur J Clin Microbiol Infect Dis. 30:1039–1044. 2011. View Article : Google Scholar : PubMed/NCBI
8	Rikimaru T: Endobronchial tubereulosis. Expert Rev Anti Infect Ther. 2:245–251. 2004. View Article : Google Scholar
9	He RX and Zhao SY: Analysis of clinical manifestations and diagnosis of 102 children with bronchial tuberculosis. Zhonghua Er Ke Za Zhi. 50:737–739. 2012.(In Chinese).
10	Tang SJ, Xiao HP, Hu HL, et al: Clinical characteristic, diagnostic standard and types of endobronchial tuberculosis: An analysis of 278 cases. Chinese Journal of Clinicians (Electronic Edition). 3:32–40. 2009.(In Chinese).
11	Jung SW, Kim MW, Cho SK, et al: A case of endobronchial aspergilloma associated with foreign body in immunocompetent patient without underlying lung disease. Tuberc Respir Dis (Seoul). 74:231–234. 2013. View Article : Google Scholar : PubMed/NCBI
12	Verma A, Park HY, Lim SY, et al: Posttuberculosis tracheobronchial stenosis: use of CT to optimize the time of silicone stent removal. Radiology. 263:562–568. 2012. View Article : Google Scholar : PubMed/NCBI
13	Zhu XH, Shao J, You ZQ, et al: The diagnostic value of multi-slice spiral CT in endobronchial tuberculosis. Chinese Journal of Radiology. 38:26–29. 2004.(In Chinese).
14	Jiang HN, Zuo JM and He LX: The diagnosis and therapy advancement of tracheo-bronchial tuberculosis. Bulletin of the Chinese Antituberculosis Association. 22:50–54. 2000.(In Chinese).
15	Iwamoto Y, Miyazawa T, Kurimoto N, et al: Interventional bronchoscopy in the management of airway stenosis due to tracheobronchial tuberculosis. Chest. 126:1344–1352. 2004. View Article : Google Scholar : PubMed/NCBI
16	Chhajed PN, Malouf MA and Glanville AR: Bronchoscopic dilatation in the management of benign (non-transplant) tracheobronchial stenosis. Intern Med J. 31:512–516. 2001. View Article : Google Scholar : PubMed/NCBI