Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells

  • Authors:
    • Wei Wang
    • Yuyun Wang
    • Chunlei Zhang
    • Mengmeng Sun
    • Xiaoyin Zhu
  • View Affiliations / Copyright

    Affiliations: Basic Medical Department, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China
  • Pages: 983-987
    |
    Published online on: June 24, 2014
       https://doi.org/10.3892/etm.2014.1806
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In order to investigate the effect of sodium ferulate (SF) on voltage‑activated K+ channels, the delayed rectifier K+ current (Ik) in PC12 rat pheochromocytoma cells was recorded using the automated patch‑clamp method. The results indicated that following the application of SF, the Ik in PC12 cells was significantly decreased in a concentration‑dependent manner. The analysis of activation kinetic curves and inactivation kinetic curves of Ik showed that SF had an effect on the activation and inactivation kinetics. Following the application of 15.3 µM SF, the activation curve of the Ik of PC12 cells was shifted to positive potentials and the inactivation curve of the Ik of PC12 cells was shifted to negative potentials. This study revealed that the delayed rectifier K+ currents of PC12 cells were inhibited following SF treatment in a concentration‑dependent manner. The mechanism may be associated with the delayed activation and enhanced inactivation of Ik‑associated channels.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Wang BH and Ou-Yang JP: Pharmacological actions of sodium ferulate in cardiovascular system. Cardiovasc Drug Rev. 23:161–172. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Srinivasan M, Sudheer AR and Menon VP: Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr. 40:92–100. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Zhang A, Gao Y, Zhong X, et al: Effect of sodium ferulate on the hyperalgesia mediated by P2X3 receptor in the neuropathic pain rats. Brain Res. 1313:215–221. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Ficker E and Heinemann U: Slow and fast transient potassium currents in cultured rat hippocampal cells. J Physiol. 445:431–455. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Wu LG and Saggau P: Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci. 20:204–212. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Breton JD, Poisbeau P and Darbon P: Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord. Mol Pain. 5:632009. View Article : Google Scholar : PubMed/NCBI

7 

Chen BS, Peng H and Wu SN: Dexmedetomidine, an alpha2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current. Br J Anaesth. 103:244–254. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Malin SA and Nerbonne JM: Delayed rectifier K+ currents, IK, are encoded by Kv2 alpha-subunits and regulate tonic firing in mammalian sympathetic neurons. J Neurosci. 22:10094–10105. 2002.PubMed/NCBI

9 

Schnee ME and Brown BS: Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther. 286:709–717. 1998.PubMed/NCBI

10 

Milligan CJ and Möller C: Automated planar patch-clamp. Methods Mol Biol. 998:171–187. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wacker SJ, Jurkowski W, Simmons KJ, et al: Identification of selective inhibitors of the potassium channel Kv1.1–1.2((3)) by high-throughput virtual screening and automated patch clamp. ChemMedChem. 7:1775–1783. 2012.PubMed/NCBI

12 

Alani B, Salehi R, Sadeghi P, et al: Silencing of Hsp90 chaperone expression protects against 6-hydroxydopamine toxicity in PC12 cells. J Mol Neurosci. 52:392–402. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Mias C, Coatrieux C, Denis C, et al: Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability. PLoS One. 8:e790682013. View Article : Google Scholar : PubMed/NCBI

14 

Greene LA and Tischler AS: Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA. 73:2424–2428. 1976. View Article : Google Scholar

15 

Hoshi T and Aldrich RW: Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells. J Gen Physiol. 91:73–106. 1988.

16 

Wang Y, Yuan J, Yuan X, et al: Observation of antinociceptive effects of oxymatrine and its effect on delayed rectifier K+ currents (Ik) in PC12 cells. Neurochem Res. 37:2143–2149. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Xu Y, Zhang L, Shao T, et al: Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses. Metab Brain Dis. 28:571–583. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Zhang L, Wang QD, Shi HM and Pan JC: Influence of ferulic acid on the pain-depression dyad induced by reserpine. Yao Xue Xue Bao. 48:32–37. 2013.(In Chinese).

19 

Fu ZY, DU CY, Yao Y, et al: Effects of beta-cypermethrin on voltage-gated potassium channels in rat hippocampal CA3 neurons. Sheng Li Xue Bao. 59:63–70. 2007.(In Chinese).

20 

Tian YT, Liu ZW, Yao Y, Yang Z and Zhang T: Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons. Neurotoxicology. 30:269–273. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Füll Y, Seebohm G, Lerche H and Maljevic S: A conserved threonine in the S1–S2 loop of KV7.2 and KV7.3 channels regulates voltage-dependent activation. Pflugers Arch. 465:797–804. 2013.

22 

Carrasquillo Y, Burkhalter A and Nerbonne JM: A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons. J Physiol. 590:3877–3890. 2012.

23 

Friederich P and Urban BW: Interaction of intravenous anesthetics with human neuronal potassium currents in relation to concentrations. Anesthesiology. 91:1853–1860. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Friederich P, Benzenberg D and Urban BW: Ketamine and propofol differentially inhibit human neuronal K+ channels. Eur J Anaesthesiol. 18:177–183. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Zhang T, Wang Z, Wang L, et al: Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. PLoS Genet. 9:e10033272013. View Article : Google Scholar : PubMed/NCBI

26 

Zhao L, Lou J, Wu H, Yin Y and Kang Y: Effects of taurine-magnesium coordination compound on ionic channels in rat ventricular myocytes of arrhythmia induced by ouabain. Biol Trace Elem Res. 147:275–284. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang W, Wang Y, Zhang C, Sun M and Zhu X: Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells. Exp Ther Med 8: 983-987, 2014.
APA
Wang, W., Wang, Y., Zhang, C., Sun, M., & Zhu, X. (2014). Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells. Experimental and Therapeutic Medicine, 8, 983-987. https://doi.org/10.3892/etm.2014.1806
MLA
Wang, W., Wang, Y., Zhang, C., Sun, M., Zhu, X."Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells". Experimental and Therapeutic Medicine 8.3 (2014): 983-987.
Chicago
Wang, W., Wang, Y., Zhang, C., Sun, M., Zhu, X."Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells". Experimental and Therapeutic Medicine 8, no. 3 (2014): 983-987. https://doi.org/10.3892/etm.2014.1806
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Wang Y, Zhang C, Sun M and Zhu X: Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells. Exp Ther Med 8: 983-987, 2014.
APA
Wang, W., Wang, Y., Zhang, C., Sun, M., & Zhu, X. (2014). Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells. Experimental and Therapeutic Medicine, 8, 983-987. https://doi.org/10.3892/etm.2014.1806
MLA
Wang, W., Wang, Y., Zhang, C., Sun, M., Zhu, X."Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells". Experimental and Therapeutic Medicine 8.3 (2014): 983-987.
Chicago
Wang, W., Wang, Y., Zhang, C., Sun, M., Zhu, X."Effect of sodium ferulate on delayed rectifier K+ currents in PC12 cells". Experimental and Therapeutic Medicine 8, no. 3 (2014): 983-987. https://doi.org/10.3892/etm.2014.1806
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team