A patient with agranulocytosis following the discontinuation of methimazole treatment for 4 months: A case report

Bai,Xiao‑Su; Liu,Jing‑Hai; Xiao,Shao‑Mei

doi:10.3892/etm.2014.1817

September-2014 Volume 8 Issue 3

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September-2014 Volume 8 Issue 3

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Case Report

A patient with agranulocytosis following the discontinuation of methimazole treatment for 4 months: A case report

Authors:
- Xiao‑Su Bai
- Jing‑Hai Liu
- Shao‑Mei Xiao
View Affiliations / Copyright

Affiliations: Department of Metabolism and Endocrinology, People's Hospital Of New District Longhua Shenzhen, Shenzhen, Guangdong 518109, P.R.China
Pages: 823-825
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Published online on: June 30, 2014

https://doi.org/10.3892/etm.2014.1817
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Abstract

Agranulocytosis is a rare and serious adverse effect of antithyroid drugs (ATD), in particular methimazole (MMI), and usually develops within 3 months following the start of uninterrupted ATD treatment. Agranulocytosis may also develop for the first time following interruption and subsequent resumption of the same ATD treatment. In this case report, a 27‑year‑old female, who was treated for thyrotoxicosis with MMI, developed agranulocytosis following the discontinuation of MMI treatment for four months. To the best of our knowledge, this is the first study to report this. The aim of this report is to increase the awareness of physicians of the onset of agranulocytosis when MMI is discontinued, and to demonstrate that MMI should be used with caution.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A patient with agranulocytosis following the discontinuation of methimazole treatment for 4 months: A case report

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Abstract

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