Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway

  • Authors:
    • Xun Yuan
    • Songbo Jing
    • Lingzhen Wu
    • Lianglong Chen
    • Jun Fang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Fujian Medical University Union Hospital, Fujian Institute of Coronary Heart Disease, Fuzhou, Fujian 350001, P.R. China
  • Pages: 973-977
    |
    Published online on: July 2, 2014
       https://doi.org/10.3892/etm.2014.1820
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tanshinone IIA, one of the active ingredients in the Chinese medicine Danshen, is cardioprotective when applied prior to sustained myocardial ischemia. The present study aimed to investigate whether pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury when applied prior to prolonged reperfusion following a sustained ischemia. A total of 88 Sprague‑Dawley rats received 30 min myocardial ischemia followed by 5 or 120 min reperfusion. Compared with the ischemia‑reperfusion model group, the group that received an intravenous injection of 10 mg/kg tanshinone IIA prior to reperfusion had a reduced myocardial infarct size, higher levels of phospho‑Akt and phospho‑endothelial nitric oxide synthase and less reduction in the optical density of the mitochondria at 540 nm, indicating that the mitochondrial permeability transition (MPT) was attenuated. The cardioprotective effect conferred by tanshinone IIA was abolished by LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K). These results demonstrate that tanshinone IIA postconditioning protects the myocardium from ischemia‑reperfusion injury through the PI3K/Akt pathway, and the MPT may be also involved in this process.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Braunwald E and Kloner RA: Myocardial reperfusion: a double-edged sword? J Clin Invest. 76:1713–1719. 1985. View Article : Google Scholar : PubMed/NCBI

2 

Murry CE, Jennings RB and Reimer KA: Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 74:1124–1136. 1986. View Article : Google Scholar

3 

Maulik N, Engelman RM, Wei Z, et al: Interleukin-1 alpha preconditioning reduces myocardial ischemia reperfusion injury. Circulation. 88:II387–II394. 1993.PubMed/NCBI

4 

Zhao ZQ, Corvera JS, Halkos ME, et al: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 285:H579–H588. 2003.PubMed/NCBI

5 

Tissier R, Waintraub X, Couvreur N, et al: Pharmacological postconditioning with the phytoestrogen genistein. J Mol Cell Cardiol. 42:79–87. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Gao S, Liu Z, Li H, et al: Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis. 220:3–10. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Xu W, Yang J and Wu LM: Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats. Pharmazie. 64:332–336. 2009.PubMed/NCBI

8 

Tsang A, Hausenloy DJ, Mocanu MM and Yellon DM: Postconditioning: a form of ‘modified reperfusion’ protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res. 95:230–232. 2004.

9 

Lim SY, Davidson SM, Hausenloy DJ and Yellon DM: Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore. Cardiovasc Res. 75:530–535. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Fang J, Chen L, Wu L and Li W: Intra-cardiac remote ischemic post-conditioning attenuates ischemia-reperfusion injury in rats. Scand Cardiovasc J. 43:386–394. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Fang J, Wu L and Chen L: Postconditioning attenuates cardiocyte ultrastructure injury and apoptosis by blocking mitochondrial permeability transition in rats. Acta Cardiol. 63:377–387. 2008. View Article : Google Scholar

12 

Wang G, Liem DA, Vondriska TM, et al: Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Am J Physiol Heart Circ Physiol. 288:H1290–H1295. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Baines CP, Song CX, Zheng YT, et al: Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria. Circ Res. 92:873–880. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Hausenloy DJ and Yellon DM: New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res. 61:448–460. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Yellon DM and Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med. 357:1121–1135. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Fu J, Huang H, Liu J, et al: Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmacol. 568:213–221. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Tu EY, Zhou YG, Wang ZH, Liang QS and Yang GT: Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats. Chin J Integr Med. 15:365–370. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Shan H, Li X, Pan Z, et al: Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1. Br J Pharmacol. 158:1227–1235. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Pan C, Lou L, Huo Y, et al: Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways. Ther Adv Cardiovasc Dis. 5:99–111. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Zhang Y, Wei L, Sun D, et al: Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats. Diabetes Obes Metab. 12:316–322. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Gao F, Gao E, Yue TL, et al: Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 105:1497–1502. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Halestrap AP, Kerr PM, Javadov S and Woodfield KY: Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta. 1366:79–94. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Bopassa JC, Ferrera R, Gateau-Roesch O, Couture-Lepetit E and Ovize M: PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning. Cardiovasc Res. 69:178–185. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Argaud L, Gateau-Roesch O, Raisky O, et al: Postconditioning inhibits mitochondrial permeability transition. Circulation. 111:194–197. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Zhang SZ, Ye ZG, Xia Q, Zhang W and Bruce I: Inhibition of mitochondrial permeability transition pore: A possible mechanism for cardioprotection conferred by pretreatment with tanshinone IIA. Conf Proc IEEE Eng Med Biol Soc. 3:2276–2279. 2005.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yuan X, Jing S, Wu L, Chen L and Fang J: Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway. Exp Ther Med 8: 973-977, 2014.
APA
Yuan, X., Jing, S., Wu, L., Chen, L., & Fang, J. (2014). Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway. Experimental and Therapeutic Medicine, 8, 973-977. https://doi.org/10.3892/etm.2014.1820
MLA
Yuan, X., Jing, S., Wu, L., Chen, L., Fang, J."Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway". Experimental and Therapeutic Medicine 8.3 (2014): 973-977.
Chicago
Yuan, X., Jing, S., Wu, L., Chen, L., Fang, J."Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway". Experimental and Therapeutic Medicine 8, no. 3 (2014): 973-977. https://doi.org/10.3892/etm.2014.1820
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan X, Jing S, Wu L, Chen L and Fang J: Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway. Exp Ther Med 8: 973-977, 2014.
APA
Yuan, X., Jing, S., Wu, L., Chen, L., & Fang, J. (2014). Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway. Experimental and Therapeutic Medicine, 8, 973-977. https://doi.org/10.3892/etm.2014.1820
MLA
Yuan, X., Jing, S., Wu, L., Chen, L., Fang, J."Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway". Experimental and Therapeutic Medicine 8.3 (2014): 973-977.
Chicago
Yuan, X., Jing, S., Wu, L., Chen, L., Fang, J."Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the phosphatidylinositol 3‑kinase pathway". Experimental and Therapeutic Medicine 8, no. 3 (2014): 973-977. https://doi.org/10.3892/etm.2014.1820
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team