Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase‑1 and matrix metalloproteinase‑10

Jiang,Hao; Zhou,Yujuan; Liao,Qianjin; Ouyang,Hongjuan

doi:10.3892/etm.2014.1822

September-2014 Volume 8 Issue 3

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September-2014 Volume 8 Issue 3

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Article

Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase‑1 and matrix metalloproteinase‑10

Authors:
- Hao Jiang
- Yujuan Zhou
- Qianjin Liao
- Hongjuan Ouyang
View Affiliations / Copyright

Affiliations: Gastric Cancer Research Center of Hunan, Department of Oncology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China
Pages: 769-774
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Published online on: July 3, 2014

https://doi.org/10.3892/etm.2014.1822
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Abstract

The aim of this study was to investigate the effect and mechanism of Helicobacter pylori infection in the invasion and metastasis of gastric cancer. Specimens from 80 patients with gastric cancer (of which 20 patients had metastatic gastric cancer) and 40 patients with chronic gastritis were included in this study. H. pylori infection was determined by ELISA and the expression of matrix metalloproteinase‑1 (MMP‑1) and MMP‑10 was observed using immunohistochemistry. The correlation between H. pylori infection and the clinical pathological features of gastric cancer was analyzed by SPSS 13.0 software. The protein expression levels of MMP‑1 and MMP‑10 in MGC‑803 cells infected with H. pylori were analyzed using western blotting. H. pylori infection was found in 62 of the 80 patients with gastric cancer and in 13 of the 40 patients with chronic gastritis. In addition, H. pylori infection was correlated with the staging and lymph node metastasis, but not with the gender, age and histological types of patients. H. pylori infection was also significantly correlated with the expression of MMP‑1 and MMP‑10 (r=0.8718, P<0.05 and r=0.5477, P<0.05, respectively). The expression of MMP‑1 and MMP‑10 was significantly upregulated following induction by H. pylori infection (P<0.05), with significant effects occurring following infection for 12 and 6 h, respectively. H. pylori infection may promote the invasion and metastasis of gastric cancer by increasing the expression of MMP‑1 and MMP‑10.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase‑1 and matrix metalloproteinase‑10

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