Immunohistochemical study of nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 in invasive breast carcinoma of no special type

  • Authors:
    • Krzysztof Symonowicz
    • Kamila Duś-Szachniewicz
    • Marta Woźniak
    • Marek Murawski
    • Paweł Kołodziej
    • Beata Osiecka
    • Kamil Jurczyszyn
    • Piotr Ziółkowski
  • View Affiliations

  • Published online on: July 16, 2014     https://doi.org/10.3892/etm.2014.1847
  • Pages: 1039-1046
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Abstract

The aim of the present study was to investigate the immunohistochemical expression of nuclear ubiquitous casein and cyclin‑dependent kinases substrate 1 (NUCKS1) in invasive breast carcinoma of no special type, in association with clinicopathological characteristics, including the tumor grade, frequency of lymph node involvement and distant metastasis. In addition, associations between NUCKS1 and other tumor subtype markers, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki‑67 and cytokeratin 5/6 (CK 5/6), were investigated. NUCKS1 expression was shown to be associated with the formation of distant metastases and lymph node involvement. Furthermore, an association between the presence of NUCKS1 and histological grading was observed. The results confirmed that the expression of NUCKS1 in low grade invasive breast carcinoma of no special type was significantly less common compared with cases of high grade carcinoma. With regard to the additional tumor subtype markers, NUCKS1 expression was demonstrated to be significantly associated with Ki‑67 and CK 5/6; however, no association was identified with ER, PR and HER2. Therefore, NUCKS1 may be a novel prognostic marker in the histopathological evaluation of invasive breast carcinoma of no special type.
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October 2014
Volume 8 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Symonowicz K, Duś-Szachniewicz K, Woźniak M, Murawski M, Kołodziej P, Osiecka B, Jurczyszyn K and Ziółkowski P: Immunohistochemical study of nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 in invasive breast carcinoma of no special type. Exp Ther Med 8: 1039-1046, 2014
APA
Symonowicz, K., Duś-Szachniewicz, K., Woźniak, M., Murawski, M., Kołodziej, P., Osiecka, B. ... Ziółkowski, P. (2014). Immunohistochemical study of nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 in invasive breast carcinoma of no special type. Experimental and Therapeutic Medicine, 8, 1039-1046. https://doi.org/10.3892/etm.2014.1847
MLA
Symonowicz, K., Duś-Szachniewicz, K., Woźniak, M., Murawski, M., Kołodziej, P., Osiecka, B., Jurczyszyn, K., Ziółkowski, P."Immunohistochemical study of nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 in invasive breast carcinoma of no special type". Experimental and Therapeutic Medicine 8.4 (2014): 1039-1046.
Chicago
Symonowicz, K., Duś-Szachniewicz, K., Woźniak, M., Murawski, M., Kołodziej, P., Osiecka, B., Jurczyszyn, K., Ziółkowski, P."Immunohistochemical study of nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 in invasive breast carcinoma of no special type". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1039-1046. https://doi.org/10.3892/etm.2014.1847