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Article

Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns

  • Authors:
    • Kemal Varim Numanoğlu
    • Duygu Tatli
    • Sibel Bektaş
    • Ebubekir Er
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Faculty of Medicine, Bülent Ecevit University, Kozlu, Zonguldak 67600, Turkey, Department of Pathology, Faculty of Medicine, Bülent Ecevit University, Kozlu, Zonguldak 67600, Turkey
  • Pages: 1087-1091
    |
    Published online on: July 17, 2014
       https://doi.org/10.3892/etm.2014.1851
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Abstract

Current treatment strategies against the development of corrosive esophageal strictures remain unsatisfactory. Thus, the aim of the present study was to investigate the efficacy of keratinocyte growth factor, in the form of palifermin, for the prevention of stricture development following esophageal caustic injuries in a rat model. A total of 32 female Wistar albino rats were divided into four groups, which included the control (C), burn (B), steroid (S) and steroid plus palifermin (S/P) groups. An experimental corrosive esophageal burn model was established in the B, S and S/P groups. Weight gain was recorded and histopathological evaluation was performed for each group. Weight gain in the S and B groups was compared with the control group and statistically significant differences were observed. In addition, statistically significant differences in weight gain were observed between the S/P group and the B group. Histopathologically, statistically significant differences were identified with regard to submucosal collagen deposition, muscularis mucosa and tunica muscularis damage when comparing the B group with the C group. In addition, statistically significant differences were observed when comparing the S and S/P groups with the B group. Furthermore, significant submucosal collagen deposition and tunica muscularis damage were observed in the S group when compared with the S/P group. The stenosis indexes in the C and S groups were significantly lower compared with the B group. In addition, the stenosis index in the S/P group was significantly lower compared with the S group. To the best of our knowledge, the present study is the first to investigate the effect of palifermin on corrosive esophageal burns. The addition of palifermin to the corrosive esophageal burn standard treatment regimen was found to reduce the degree of fibrosis and ameliorate histopathological damage in an experimental model of corrosive esophagitis in rats.
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Copy and paste a formatted citation
Spandidos Publications style
Numanoğlu KV, Tatli D, Bektaş S and Er E: Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns. Exp Ther Med 8: 1087-1091, 2014.
APA
Numanoğlu, K.V., Tatli, D., Bektaş, S., & Er, E. (2014). Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns. Experimental and Therapeutic Medicine, 8, 1087-1091. https://doi.org/10.3892/etm.2014.1851
MLA
Numanoğlu, K. V., Tatli, D., Bektaş, S., Er, E."Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns". Experimental and Therapeutic Medicine 8.4 (2014): 1087-1091.
Chicago
Numanoğlu, K. V., Tatli, D., Bektaş, S., Er, E."Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1087-1091. https://doi.org/10.3892/etm.2014.1851
Copy and paste a formatted citation
x
Spandidos Publications style
Numanoğlu KV, Tatli D, Bektaş S and Er E: Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns. Exp Ther Med 8: 1087-1091, 2014.
APA
Numanoğlu, K.V., Tatli, D., Bektaş, S., & Er, E. (2014). Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns. Experimental and Therapeutic Medicine, 8, 1087-1091. https://doi.org/10.3892/etm.2014.1851
MLA
Numanoğlu, K. V., Tatli, D., Bektaş, S., Er, E."Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns". Experimental and Therapeutic Medicine 8.4 (2014): 1087-1091.
Chicago
Numanoğlu, K. V., Tatli, D., Bektaş, S., Er, E."Efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1087-1091. https://doi.org/10.3892/etm.2014.1851
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