A case of membranous nephropathy and myeloperoxidase anti‑neutrophil cytoplasmic antibody‑associated glomerulonephritis

Hu,Zhi‑Juan; Niu,Kai; Liu,Bing; Shi,Ya‑Nan

doi:10.3892/etm.2014.1852

A case of membranous nephropathy and myeloperoxidase anti‑neutrophil cytoplasmic antibody‑associated glomerulonephritis

Authors:
- Zhi‑Juan Hu
- Kai Niu
- Bing Liu
- Ya‑Nan Shi
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Affiliations: Department of Nephrology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China
Published online on: July 17, 2014 https://doi.org/10.3892/etm.2014.1852
Pages: 1170-1172

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Abstract

Membranous nephropathy (MN) may be a primary disease or secondary to autoimmune conditions such as systemic lupus erythematosus, infection (for example, with hepatitis B or C virus), cancer or drugs. In primary MN, crescents are rarely observed. Therefore, the presence of crescents suggests another underlying disease, for example lupus nephritis, anti‑glomerular basement membrane disease or anti‑neutrophil cytoplasmic antibody‑associated glomerulonephritis (ANCA‑GN). The coexistence of primary MN and ANCA‑GN is rare. In the present case, a 51‑year‑old female with mild edema in the lower extremities for 1 year was admitted to hospital for renal biopsy. The serum test for myeloperoxidase (MPO)‑ANCA was positive. The patient was diagnosed with stage 2 MN with crescentic glomerulonephritis type 3; however, no causal association was found between these two diseases in this case. Treatment was initiated with 500 mg methylprednisolone for 3 days followed by 40 mg of oral methylprednisolone together with 50 mg cyclophosphamide twice per day. One month following treatment, the biochemical data results of the patient had improved.

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