Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

Huang,Shengliang; Zhang,Xuebei; Xu,Liuyu; Li,Qing; Zhao,Qingli

doi:10.3892/etm.2014.1856

October 2014 Volume 8 Issue 4

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October 2014 Volume 8 Issue 4

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Article

Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

Authors:
- Shengliang Huang
- Xuebei Zhang
- Liuyu Xu
- Qing Li
- Qingli Zhao
View Affiliations / Copyright

Affiliations: Department of Urology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Department of Emergency, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
Pages: 1237-1240
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Published online on: July 21, 2014

https://doi.org/10.3892/etm.2014.1856
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Abstract

Nerve growth factor (NGF) has been found in the normal prostate of the Wistar rat and is regarded as an important prostatic mitogen. We have previously shown that chronic stress induced epithelial hyperplasia while sympathetic denervation caused atrophy in the male Wistar rat prostate. NGF may have been a contributing mechanism to the hyperplasia and atrophy response that was observed. The aim of the present study was to investigate the expression of NGF in the prostate of the male rat in response to chronic stress and denervation. Two weeks of restraint water‑immersion stress were used to induce a chronic stress model in Wistar rats. Denervation of the peripheral sympathetic nerve was induced by 6‑hydroxydopamine. The expression levels of NGF in the dissected prostate lobes were examined by immunohistochemistry. After 14 days of stress, proliferation of the epithelium in the ventral lobes was observed, whereas the dorsolateral lobes were almost unaffected. NGF immunoreactive protein was localized to the columnar secretory epithelium lines of the prostate tissue. Stress and denervation led to an increase in NGF expression in the ventral lobes. In conclusion, NGF was involved in the hyperplasia and atrophy in the prostate of the male rat in response to chronic stress and sympathetic denervation, and thus may be a contributing factor in the pathophysiology of the prostate.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

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