Role of serum and induced sputum surfactant protein D in predicting the response to treatment in chronic obstructive pulmonary disease

  • Authors:
    • Wei Liu
    • Chun‑Rong Ju
    • Rong‑Chang Chen
    • Zhi‑Guang Liu
  • View Affiliations

  • Published online on: July 29, 2014     https://doi.org/10.3892/etm.2014.1865
  • Pages: 1313-1317
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Abstract

This study was designed to determine the expression of serum and sputum surfactant protein D (SP‑D) in chronic obstructive pulmonary disease (COPD) and its association with treatment response. Sixty‑five treatment‑naive patients with COPD and 26 normal control subjects were recruited in the study. The concentrations of serum and sputum SP‑D were measured, and the associations of SP‑D with pulmonary function and the modified Medical Research Council dyspnea scale (mMRC) and the St. George's Respiratory Questionnaire (SGRQ) scores before and after three months of treatment with an inhaled corticosteroid and a long‑acting β2‑agonist were analyzed. The concentrations of serum and sputum SP‑D in the COPD group (45.46±37.78 and 173.23±186.93 ng/ml, respectively) were significantly higher than those of the normal control group (31.68±12.04 and 89.59±70.29 ng/ml, respectively). After three months of treatment, serum SP‑D levels were reduced to 30.7±13.9 ng/ml and were significantly lower than the baseline levels (t=2.217, P=0.031). However, no significant reduction in sputum SP‑D levels was observed following the treatment (P>0.05). A significant association between baseline sputum SP‑D and change in SGRQ activity scores (r=‑0.652, P=0.012) was observed; however no association was established with the changes in other clinical profiles following the treatment (P>0.05). This result suggested that an increased baseline sputum SP‑D may be a weak predictive indicator of response to treatment with inhaled corticosteroids and long‑acting β2‑agonists in patients with COPD.
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October 2014
Volume 8 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu W, Ju CR, Chen RC and Liu ZG: Role of serum and induced sputum surfactant protein D in predicting the response to treatment in chronic obstructive pulmonary disease. Exp Ther Med 8: 1313-1317, 2014
APA
Liu, W., Ju, C., Chen, R., & Liu, Z. (2014). Role of serum and induced sputum surfactant protein D in predicting the response to treatment in chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 8, 1313-1317. https://doi.org/10.3892/etm.2014.1865
MLA
Liu, W., Ju, C., Chen, R., Liu, Z."Role of serum and induced sputum surfactant protein D in predicting the response to treatment in chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 8.4 (2014): 1313-1317.
Chicago
Liu, W., Ju, C., Chen, R., Liu, Z."Role of serum and induced sputum surfactant protein D in predicting the response to treatment in chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 8, no. 4 (2014): 1313-1317. https://doi.org/10.3892/etm.2014.1865