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Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction

  • Authors:
    • Dilidaer Xilifu
    • Abulizi Abudula
    • Nijiati Rehemu
    • Long Zhao
    • Xinrong Zhou
    • Xiangyang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital, Xinjiang Medical University, Ürümqi, Xinjiang 830011, P.R. China, Xinjiang Key Laboratory of Molecular Biology and Endemic Diseases, Xinjiang Medical University, Ürümqi, Xinjiang 830011, P.R. China, Department of Pathology, School of Basic Medicine, Xinjiang Medical University, Ürümqi, Xinjiang 830011, P.R. China
  • Pages: 1683-1688
    |
    Published online on: October 15, 2014
       https://doi.org/10.3892/etm.2014.2027
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Abstract

Endothelial dysfunction plays a key role in the development of cardiovascular diseases, renal injuries and hypertension induced by hyperuricemia. Therapies targeting uric acid (UA) may be beneficial in cardiovascular diseases. In the present study, the effect of rosuvastatin, a 3‑hydroxy‑3‑methylglutaryl coenzyme A reductase inhibitor, was investigated to determine whether rosuvastatin improves endothelial dysfunction via the endothelial nitric oxide (NO) pathway and delays the pathogenesis of endothelial dysfunction in hyperuricemic rats. A total of 72 Sprague‑Dawley rats (age, 8 weeks) were randomly divided into six groups (12 rats per group), including the control, model, 2.5 mg/kg/day rosuvastatin, 5 mg/kg/day rosuvastatin, 10 mg/kg/day rosuvastatin and 53.57 mg/kg/day allopurinol groups. The model, rosuvastatin and allopurinol rats were subjected to hyperuricemia, induced by the administration of yeast extract powder (21 g/kg/day) and oxonic acid potassium salt (200 mg/kg/day). The hyperuricemic rats were treated with 2.5, 5.0 or 10.0 mg/kg/day rosuvastatin orally for six weeks, while rats treated with allopurinol (53.57 mg/kg/day) were used as a positive control. The serum levels of NO and the gene expression levels of endothelial NO synthase in the aortic tissue increased, whereas the serum levels of UA, endothelin‑1 and angiotensin II decreased in the hyperuricemic rats treated with rosuvastatin, particularly at a high rosuvastatin dose (10 mg/kg/day). In addition, the curative effect of the 10 mg/kg/day rosuvastatin group was evidently higher compared with the allopurinol group. Therefore, rosuvastatin may be a novel drug candidate for the treatment of hyperuricemia due to its endothelial protective properties.
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1 

Ghisi GL, Durieux A, Pinho R and Benetti M: Physical exercise and endothelial dysfunction. Arq Bras Cardiol. 95:e130–e137. 2010.(In English, Portuguese and Spanish).

2 

Gao X, Martinez-Lemus LA and Zhang C: Endothelium-derived hyperpolarizing factor and diabetes. World J Cardiol. 3:25–31. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Oelze M, Schuhmacher S and Daiber A: Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate. Exp Diabetes Res. 2010:2131762010. View Article : Google Scholar : PubMed/NCBI

4 

Sandoo A, van Zanten JJ, Metsios GS, Carroll D and Kitas GD: The endothelium and its role in regulating vascular tone. Open Cardiovasc Med J. 4:302–312. 2010.PubMed/NCBI

5 

Franses JW, Baker AB, Chitalia VC and Edelman ER: Stromal endothelial cells directly influence cancer progression. Sci Transl Med. 3:66ra52011. View Article : Google Scholar : PubMed/NCBI

6 

Barton M: Prevention and endothelial therapy of coronary artery disease. Curr Opin Pharmacol. 13:226–241. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Mount DB: The kidney in hyperuricemia and gout. Curr Opin Nephrol Hypertens. 22:216–223. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Bakris GL, Doghramji PP, Keenan RT and Silber SH: CaseBook challenges: Managing gout, hyperuricemia and comorbidities - dialogue with the experts. Am J Med. 127:S12014. View Article : Google Scholar : PubMed/NCBI

9 

Sautner J, Gruber J, Herold M, Zwerina J and Leeb BF: Austrian 3e-recommendations for diagnosis and management of gout 2013. Wien Klin Wochenschr. 126:79–89. 2014.(In German).

10 

Maruhashi T, Nakashima A, Soga J, et al: Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women. BMJ Open. 3:e0036592013. View Article : Google Scholar : PubMed/NCBI

11 

Xu Y, Zhu J, Gao L, et al: Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PLoS One. 8:e782062013. View Article : Google Scholar : PubMed/NCBI

12 

Ndrepepa G, Cassese S, Braun S, et al: A gender-specific analysis of association between hyperuricaemia and cardiovascular events in patients with coronary artery disease. Nutr Metab Cardiovasc Dis. 23:1195–1201. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Fan Y and Chen YE: Combined therapeutic strategy to improve vascular endothelial function after implantation of sirolimus-eluting stents. Circ J. 75:1051–1052. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Ghaffari N, Ball C, Kennedy JA, Stafford I and Beltrame JF: Acute modulation of vasoconstrictor responses by pravastatin in small vessels. Circ J. 75:1506–1514. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Foody JM, Toth PP, Tomassini JE, et al: Changes in LDL-C levels and goal attainment associated with addition of ezetimibe to simvastatin, atorvastatin, or rosuvastatin compared with titrating statin monotherapy. Vasc Health Risk Manag. 9:719–727. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Maji D, Shaikh S, Solanki D and Gaurav K: Safety of statins. Indian J Endocrinol Metab. 17:636–646. 2013. View Article : Google Scholar

17 

Kones R: Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease - a perspective. Drug Des Devel Ther. 4:383–413. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Savoia C, Sisalli MJ, Di Renzo G, Annunziato L and Scorziello A: Rosuvastatin-induced neuroprotection in cortical neurons exposed to OGD/reoxygenation is due to nitric oxide inhibition and ERK1/2 pathway activation. Int J Physiol Pathophysiol Pharmacol. 3:57–64. 2011.PubMed/NCBI

19 

Chen GL, Zhang QL, Ma XQ and Xu SY: Hyperuricemia model induced by yeast in mice. Zhongguo Yao Li Xue Tong Bao. 19:467–469. 2003.(In Chinese).

20 

Guide for the care and use of laboratory animals. 8th Edition. The National Academies Press; Washington, D.C, USA: pp. 11–35. 2011

21 

Xilifu D, Zhao P, Song LJ, Rehemu N and Zhang XY: Development of secondary cardiovascular disease in hyperuricemia model rats induced by yeast extract combined with oteracil potassium. Zhongguo Zuzhi Gongcheng Yanjiu. 16:1994–1998. 2012.

22 

Tomiyama H, Higashi Y, Takase B, et al: Relationships among hyperuricemia, metabolic syndrome, and endothelial function. Am J Hypertens. 24:770–774. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Hwa KS, Chung DM, Chung YC and Chun HK: Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice. Phytother Res. 25:1415–1417. 2011.PubMed/NCBI

24 

Wang Y and Bao X: Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms. Eur J Med Res. 18:262013. View Article : Google Scholar : PubMed/NCBI

25 

Schwartz IF, Grupper A, Chernichovski T, et al: Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats. J Vasc Res. 48:252–260. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Zharikov SI, Swenson ER, Lanaspa M, et al: Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension? Med Hypotheses. 74:1069–1074. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Tsai IJ, Croft KD, Puddey IB, Beilin LJ and Barden A: 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. Am J Physiol Heart Circ Physiol. 300:H1194–H1200. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Lagerqvist EL, Finnin BA, Pouton CW and Haynes JM: Endothelin-1 and angiotensin II modulate rate and contraction amplitude in a subpopulation of mouse embryonic stem cell-derived cardiomyocyte-containing bodies. Stem Cell Res. 6:23–33. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Papageorgiou N, Tousoulis D, Antoniades C, Giolis A, Briasoulis A and Stefanadis C: The impact of statin administration in acute coronary syndromes. Hellenic J Cardiol. 51:250–261. 2010.PubMed/NCBI

30 

Doi T, Sakoda T, Akagami T, et al: Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes. Am J Physiol Heart Circ Physiol. 295:H1279–H1287. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Takahashi Y, Satoh M, Tabuchi T and Nakamura M: Prospective, randomized, single-blind comparison of effects of 6 months’ treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease. Heart Vessels. 27:337–343. 2012.

32 

Ali F, Zakkar M, Karu K, et al: Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow. J Biol Chem. 284:18882–18892. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Lardizabal JA and Deedwania PC: The anti-ischemic and anti-anginal properties of statins. Curr Atheroscler Rep. 13:43–50. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Pasceri V, Willerson JT and Yeh ET: Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 102:2165–2168. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Datar R1, Kaesemeyer WH, Chandra S, et al: Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx. Br J Pharmacol. 160:1765–1772. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Miyata R, Hiraiwa K, Cheng JC, et al: Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10). Toxicol Appl Pharmacol. 272:1–11. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Meda C, Plank C, Mykhaylyk O, Schmidt K and Mayer B: Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. Pharmacol Rep. 62:100–112. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Zhou Q and Liao JK: Pleiotropic effects of statins. Basic research and clinical perspectives. Circ J. 74:818–826. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Yu ZF, Yang C, Qiu X, Chen Y, Kong LD and Wang MS: The influence of daphnin on rats suffering hyperuricemia. Zhongguo Yi Ke Da Xue Xue Bao. 33:142–145. 2002.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Xilifu D, Abudula A, Rehemu N, Zhao L, Zhou X and Zhang X: Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction. Exp Ther Med 8: 1683-1688, 2014.
APA
Xilifu, D., Abudula, A., Rehemu, N., Zhao, L., Zhou, X., & Zhang, X. (2014). Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction. Experimental and Therapeutic Medicine, 8, 1683-1688. https://doi.org/10.3892/etm.2014.2027
MLA
Xilifu, D., Abudula, A., Rehemu, N., Zhao, L., Zhou, X., Zhang, X."Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction". Experimental and Therapeutic Medicine 8.6 (2014): 1683-1688.
Chicago
Xilifu, D., Abudula, A., Rehemu, N., Zhao, L., Zhou, X., Zhang, X."Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1683-1688. https://doi.org/10.3892/etm.2014.2027
Copy and paste a formatted citation
x
Spandidos Publications style
Xilifu D, Abudula A, Rehemu N, Zhao L, Zhou X and Zhang X: Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction. Exp Ther Med 8: 1683-1688, 2014.
APA
Xilifu, D., Abudula, A., Rehemu, N., Zhao, L., Zhou, X., & Zhang, X. (2014). Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction. Experimental and Therapeutic Medicine, 8, 1683-1688. https://doi.org/10.3892/etm.2014.2027
MLA
Xilifu, D., Abudula, A., Rehemu, N., Zhao, L., Zhou, X., Zhang, X."Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction". Experimental and Therapeutic Medicine 8.6 (2014): 1683-1688.
Chicago
Xilifu, D., Abudula, A., Rehemu, N., Zhao, L., Zhou, X., Zhang, X."Effect of rosuvastatin on hyperuricemic rats and the protective effect on endothelial dysfunction". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1683-1688. https://doi.org/10.3892/etm.2014.2027
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