Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis
- Authors:
- Biao Qian
- Liying Zheng
- Qinzhang Wang
- Guofu Ding
View Affiliations
Affiliations: Department of Urology, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832003, P.R. China, The Office of In‑Hospital Infection Control, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832003, P.R. China
- Published online on: November 4, 2014 https://doi.org/10.3892/etm.2014.2047
-
Pages:
183-186
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
The aim of the present study was to investigate the correlation between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of urolithiasis and dyslipidemia. A total of 180 Uyghur individuals, including 90 urolithiasis patients and 90 healthy controls, were enrolled in this study. The blood lipid profiles of the patients and controls were investigated and compared, and the composition of the urinary calculi was determined. The polymorphisms of the ApoE alleles were analyzed using polymerase chain reaction‑restriction fragment length polymorphism analysis. Three common genotypes of the ApoE gene, E3/3, E3/4 and E4/4, were detected in the urolithiasis patients and control group. In the patient group, 28 patients with the E3/3 genotype (30.1%), 58 patients with the E3/4 genotype (64.4%) and four patients with the E4/4 genotype (4.5%) were identified. By contrast, in the control group, 52 patients with the E3/3 genotype (57.8%), 35 patients with the E3/4 genotype (38.9%) and three patients with the E4/4 genotype (3.3%) were identified. The frequency of the E3/4 genotype was found to be significantly higher in the patient group when compared with the control group (χ2=12.96; P<0.001). In addition, the frequency of the E4 allele was significantly higher in the patient group when compared with the control group (χ2= 6.61; P=0.025). In conclusion, the occurrence of urolithiasis was found to be associated with ApoE gene polymorphisms, and the E4 allele may be a potential susceptibility factor for urolithiasis.
View References
|
1
|
Gu Y, Wang GZ, He W, Zhang J, Yang JW,
Yang F and Ye M: Analysis of relative factors of urinary stones
between patients of urinary stone and the health people in Shanghai
Pudong area. Lin Chang Mi Niao Wai Ke Za Zhi. 26:702–705. 2011.(In
Chinese).
|
|
2
|
Li LD: A primer on causes, prevention and
treatment of urolithiasis. Hang Kong Hang Tian Yi Xue Za Zhi.
22:688–689. 2011.(In Chinese).
|
|
3
|
Ye RG: Dyslipidemia and
Dyslipoproteinemia. Internal Medicine. 5th Edition. People’s
Medical Publishing House; Beijing: pp. 834–837. 2002
|
|
4
|
Wilkinson IB, Prasad K, Hall IR, et al:
Increased central pulse pressure and augmentation index in subjects
with hypercholesterolemia. J Am Coll Cardiol. 39:1005–1011. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Evans RM, Hui S, Perkins A, Lahiri DK,
Poirier J and Farlow MR: Cholesterol and APOE genotype interact to
influence Alzheimer disease progression. Neurology. 62:1869–1871.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lin SK, Kao JT, Tsai SM, Tsai LY, Lin MN,
Lai CJ and Zhong WL: Association of apolipoprotein E genotypes with
serum lipid profiles in a healthy population of Taiwan. Ann Clin
Lab Sci. 34:443–448. 2004.
|
|
7
|
Rall SC Jr and Mahley RW: The role of
apolipoprotein E genetic variants in lipoprotein disorders. J
Intern Med. 231:653–659. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Kong FM, Guo RX and Liu YC: The study of
relationship between cholesterol crystalization and ApoE. Zhonghua
Shi Yan Wai Ke Za Zhi. 17:520–521. 2000.(In Chinese).
|
|
9
|
Thomas A: Accelerated gene counting for
haplotype frequency estimation. Ann Hum Genet. 67:608–612. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Abate N, Chandalia M, Cabo-Chan AV Jr, Moe
OW and Sakhaee K: The metabolic syndrome and uric acid
nephrolithiasis: novel features of renal manifestation of insulin
resistance. Kidney Int. 65:386–392. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Daudon M, Traxer O, Conort P, Lacour B and
Jungers P: Type 2 diabetes increases the risk for uric acid stones.
J Am Soc Nephrol. 17:2026–2033. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhang GH: Risk factors of blood lipid
level in urinary calculi. Zhongguo Xing Ke Xue. 21:34–37. 2012.(In
Chinese).
|
|
13
|
Lu F, Guan H, Gong B, Liu X, et al:
Genetic variants in PVRL2-TOMM40-APOE region are associated with
human longevity in a Han Chinese population. PLoS One.
9:e995802014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Atadzhanov M, Mwaba MH, Mukomena PN, Lakhi
S, et al: Frequency of APOE, MTHFR and ACE polymorphisms in the
Zambian population. BMC Res Notes. 7:1942014. View Article : Google Scholar : PubMed/NCBI
|
