Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis

Qian,Biao; Zheng,Liying; Wang,Qinzhang; Ding,Guofu

doi:10.3892/etm.2014.2047

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Article

Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis

Authors:
- Biao Qian
- Liying Zheng
- Qinzhang Wang
- Guofu Ding
View Affiliations / Copyright

Affiliations: Department of Urology, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832003, P.R. China, The Office of In‑Hospital Infection Control, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832003, P.R. China
Pages: 183-186
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Published online on: November 4, 2014

https://doi.org/10.3892/etm.2014.2047
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Abstract

The aim of the present study was to investigate the correlation between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of urolithiasis and dyslipidemia. A total of 180 Uyghur individuals, including 90 urolithiasis patients and 90 healthy controls, were enrolled in this study. The blood lipid profiles of the patients and controls were investigated and compared, and the composition of the urinary calculi was determined. The polymorphisms of the ApoE alleles were analyzed using polymerase chain reaction‑restriction fragment length polymorphism analysis. Three common genotypes of the ApoE gene, E3/3, E3/4 and E4/4, were detected in the urolithiasis patients and control group. In the patient group, 28 patients with the E3/3 genotype (30.1%), 58 patients with the E3/4 genotype (64.4%) and four patients with the E4/4 genotype (4.5%) were identified. By contrast, in the control group, 52 patients with the E3/3 genotype (57.8%), 35 patients with the E3/4 genotype (38.9%) and three patients with the E4/4 genotype (3.3%) were identified. The frequency of the E3/4 genotype was found to be significantly higher in the patient group when compared with the control group (χ2=12.96; P<0.001). In addition, the frequency of the E4 allele was significantly higher in the patient group when compared with the control group (χ2= 6.61; P=0.025). In conclusion, the occurrence of urolithiasis was found to be associated with ApoE gene polymorphisms, and the E4 allele may be a potential susceptibility factor for urolithiasis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis

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