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Article

99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients

  • Authors:
    • Linlin Wei
    • Fangni Chen
    • Xuehui Zhang
    • Dangsheng Li
    • Zhongqiang Yao
    • Liyan Deng
    • Guoyou Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Affiliated Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Graduate School of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Nuclear Medicine Department, Beihai People's Hospital, Behai, Guangxi 536000, P.R. China
  • Pages: 112-116
    |
    Published online on: November 4, 2014
       https://doi.org/10.3892/etm.2014.2048
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Abstract

The aim of this study was to retrospectively determine the accuracy and feasibility of using 99mTc‑dextran (DX) lymphoscintigraphy for the localization of sentinel lymph nodes (SLNs) in breast cancer patients. The relevant factors affecting lymphoscintigraphy were also investigated. In this study, 235 breast cancer patients underwent 99mTc‑DX lymphoscintigraphic imaging and examination by a γ‑probe method in combination with blue dye staining to detect SLNs. The detection results were considered in combination with rapid frozen pathology results to determine whether SLN metastasis was positive or negative. SLNs were identified in 191 patients by γ‑probe detection among the 202 patients that tested positive by lymphoscintigraphic imaging, a coincidence rate of 94.6%. This suggested that lymph node metastasis had occurred and could be detected using lymphoscintigraphy. The axillary status of the breast cancer patients was also predicted using lymphoscintigraphy and the false‑negative rate, sensitivity, specificity and positive predictive value were 13.3% (4/30), 90.7% (39/43), 23.4% (45/192) and 13.5% (21/155), respectively. The age of the patient, menstrual status, tumor location, tumor size, pathological type, preoperative biopsy and neoadjuvant chemotherapy were unrelated to the success of lymphoscintigraphy (P>0.05). 99mTc‑DX lymphoscintigraphy is able to exactly determine the location of SLN in breast cancer patients, and can be used for guiding γ‑probe methods and sentinel lymph node biopsy.
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Copy and paste a formatted citation
Spandidos Publications style
Wei L, Chen F, Zhang X, Li D, Yao Z, Deng L and Xiao G: 99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients. Exp Ther Med 9: 112-116, 2015.
APA
Wei, L., Chen, F., Zhang, X., Li, D., Yao, Z., Deng, L., & Xiao, G. (2015). 99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients. Experimental and Therapeutic Medicine, 9, 112-116. https://doi.org/10.3892/etm.2014.2048
MLA
Wei, L., Chen, F., Zhang, X., Li, D., Yao, Z., Deng, L., Xiao, G."99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients". Experimental and Therapeutic Medicine 9.1 (2015): 112-116.
Chicago
Wei, L., Chen, F., Zhang, X., Li, D., Yao, Z., Deng, L., Xiao, G."99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients". Experimental and Therapeutic Medicine 9, no. 1 (2015): 112-116. https://doi.org/10.3892/etm.2014.2048
Copy and paste a formatted citation
x
Spandidos Publications style
Wei L, Chen F, Zhang X, Li D, Yao Z, Deng L and Xiao G: 99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients. Exp Ther Med 9: 112-116, 2015.
APA
Wei, L., Chen, F., Zhang, X., Li, D., Yao, Z., Deng, L., & Xiao, G. (2015). 99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients. Experimental and Therapeutic Medicine, 9, 112-116. https://doi.org/10.3892/etm.2014.2048
MLA
Wei, L., Chen, F., Zhang, X., Li, D., Yao, Z., Deng, L., Xiao, G."99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients". Experimental and Therapeutic Medicine 9.1 (2015): 112-116.
Chicago
Wei, L., Chen, F., Zhang, X., Li, D., Yao, Z., Deng, L., Xiao, G."99mTc‑dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients". Experimental and Therapeutic Medicine 9, no. 1 (2015): 112-116. https://doi.org/10.3892/etm.2014.2048
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