Expression and significance of transforming growth factor-β receptor type II and DPC4/Smad4 in non-small cell lung cancer

Chen,Hong; Wang,Jing‑Wei; Liu,Li‑Xin; Yan,Ji‑Dong; Ren,Shu‑Hua; Li,Yan; Lu,Zheng

doi:10.3892/etm.2014.2065

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Article

Expression and significance of transforming growth factor-β receptor type II and DPC4/Smad4 in non-small cell lung cancer

Authors:
- Hong Chen
- Jing‑Wei Wang
- Li‑Xin Liu
- Ji‑Dong Yan
- Shu‑Hua Ren
- Yan Li
- Zheng Lu
View Affiliations / Copyright

Affiliations: Department of Radiotherapy and Chemotherapy, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China, Department of Thoracic Surgery, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China
Pages: 227-231
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Published online on: November 12, 2014

https://doi.org/10.3892/etm.2014.2065
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Abstract

The aim of the present study was to investigate the expression levels of transforming growth factor‑β (TGF‑β) receptor type II (TβRII) and DPC4/Smad4 in the TGF‑β signaling pathway and the importance of these expression levels in non‑small cell lung cancer (NSCLC). The mRNA and protein expression levels of TβRII and DPC4/Smad4 were detected by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively, in NSCLC and control nonlesional lung tissues of 60 patients. The protein expression levels of DPC4/Smad4 were detected by immunohistochemistry in paraffin‑embedded samples of NSCLC. In addition, the correlations among the expression levels of TβRII and DPC4/Smad4 and their association with the clinical and pathological features of NSCLC were analyzed. The expression levels of TβRII and DPC4/Smad4 in NSCLC tissues were significantly lower when compared with the control nonlesional lung tissues (P<0.05). In addition, the expression of TβRII and DPC4/Smad4 in poorly‑differentiated NSCLC tissues was significantly lower compared with moderately‑ or well‑differentiated NSCLC tissues (P<0.05). The expression levels of TβRII and DPC4/Smad4 were significantly lower in NSCLC tissues with metastatic lymph nodes compared with tissue without metastatic lymph nodes (P<0.05). Thus, the expression levels were demonstrated to significantly correlate with the clinical and pathological stages, and subsequently were shown to be associated with the occurrence and progression of NSCLC. In conclusion, TβRII and DPC4/Smad4 may play an important role in the tumorigenesis, differentiation and progression of NSCLC via the TGF‑β signaling pathway.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression and significance of transforming growth factor-β receptor type II and DPC4/Smad4 in non-small cell lung cancer

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