Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome

Xu,Wei‑Fang; Upur,Halmurat; Wu,Yu‑Hua; Mamtimin,Batur; Yang,Jian; Ga,Yong‑Juan; You,Li

doi:10.3892/etm.2014.2085

February-2015 Volume 9 Issue 2

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February-2015 Volume 9 Issue 2

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Article

Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome

Authors:
- Wei‑Fang Xu
- Halmurat Upur
- Yu‑Hua Wu
- Batur Mamtimin
- Jian Yang
- Yong‑Juan Ga
- Li You
View Affiliations / Copyright

Affiliations: Department of Respiratory Internal Medicine, The Affiliated Chinese Medicine Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China, Department of Traditional Uyghur Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Kashgar People's Hospital of Xinjiang Uyghur Autonomous Region, Kashgar, Xinjiang 840000, P.R. China, MRI Analysis Center of the College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
Pages: 425-431
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Published online on: November 24, 2014

https://doi.org/10.3892/etm.2014.2085
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Abstract

The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non‑abnormal Savda syndrome groups and 52 healthy volunteers acted as the control group. Blood samples from the three groups were analyzed using nuclear magnetic resonance (NMR) spectroscopy combined with orthogonal projection to latent structure‑discriminant analysis. NMR tests showed that the regional distributions of the patients with COPD with abnormal Savda syndrome, those with non‑abnormal Savda syndrome and the control group were completely separate (P>0.05). The patients with COPD with abnormal Savda syndrome exhibited relatively low levels of amino acids, glycoproteins and unsaturated lipids (P<0.05) but significantly higher levels of lactic acid, carnitine, acetone and acetoacetate (P<0.05) compared with the healthy controls. Abnormal Savda syndrome was one of the main types of syndrome among the patients with COPD; increased age, a longer duration of illness and a higher disease severity were characteristic of this type of syndrome. In addition, the present study provided biochemical evidence for the TUM theory‑based classification of patients with COPD; these biomarkers can be used in the clinic for the diagnosis of COPD with abnormal Savda syndrome. The study also demonstrated that the plasma metabolic disorder in patients with COPD with abnormal Savda syndrome was more serious than that in the control and COPD with non‑abnormal Savda syndrome groups. The plasma metabolic disorder was also associated with a low immune function of the body and endocrine and energy metabolism disorders.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome

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