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Article

Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes

  • Authors:
    • Yong‑Bin Wang
    • Zhi‑Ming Ge
    • Wei‑Qiang Kang
    • Zhe‑Xun Lian
    • Jian Yao
    • Chang‑Yong Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250014, P.R. China, Qingdao Municipal Hospital, Qingdao, Shandong 266011, P.R. China, Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
  • Pages: 451-455
    |
    Published online on: November 26, 2014
       https://doi.org/10.3892/etm.2014.2090
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Abstract

Diabetic cardiomyopathy (DCM), an independent coronary heart disease that develops in diabetic individuals, is characterized by changes in the myocardial structure and function. The aim of the present study was to investigate the protective effect of rutin on DCM in a streptozotocin‑induced diabetic rat model. Rutin was orally administrated at a dose of 8 mg/kg body weight. Metabolic profiles, myocardial enzymes and oxidative stress were examined by biochemical tests. The expression levels of cellular proteins associated with apoptosis were measured by western blot analysis, while the levels of inflammatory factors were assessed by immunohistochemical analyses. Rats with DCM exhibited an abnormal metabolic profile, aberrant myocardial enzymes, elevation of oxidative stress markers, increased levels of inflammatory factors and enhanced apoptotic cell death. Notably, rutin was shown to protect and improve myocardial dysfunction, oxidative stress, apoptosis and inflammation in the hearts of the diabetic rats. In conclusion, these results indicated that rutin may have great therapeutic potential in the treatment of DCM, and possibly other cardiovascular disorders, by preventing oxidative stress, inflammation and cell death. However, further detailed studies are required to reveal the exact mechanisms underlying the protective effect of rutin.
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Copy and paste a formatted citation
Spandidos Publications style
Wang YB, Ge ZM, Kang WQ, Lian ZX, Yao J and Zhou CY: Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Exp Ther Med 9: 451-455, 2015.
APA
Wang, Y., Ge, Z., Kang, W., Lian, Z., Yao, J., & Zhou, C. (2015). Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Experimental and Therapeutic Medicine, 9, 451-455. https://doi.org/10.3892/etm.2014.2090
MLA
Wang, Y., Ge, Z., Kang, W., Lian, Z., Yao, J., Zhou, C."Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes". Experimental and Therapeutic Medicine 9.2 (2015): 451-455.
Chicago
Wang, Y., Ge, Z., Kang, W., Lian, Z., Yao, J., Zhou, C."Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes". Experimental and Therapeutic Medicine 9, no. 2 (2015): 451-455. https://doi.org/10.3892/etm.2014.2090
Copy and paste a formatted citation
x
Spandidos Publications style
Wang YB, Ge ZM, Kang WQ, Lian ZX, Yao J and Zhou CY: Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Exp Ther Med 9: 451-455, 2015.
APA
Wang, Y., Ge, Z., Kang, W., Lian, Z., Yao, J., & Zhou, C. (2015). Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Experimental and Therapeutic Medicine, 9, 451-455. https://doi.org/10.3892/etm.2014.2090
MLA
Wang, Y., Ge, Z., Kang, W., Lian, Z., Yao, J., Zhou, C."Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes". Experimental and Therapeutic Medicine 9.2 (2015): 451-455.
Chicago
Wang, Y., Ge, Z., Kang, W., Lian, Z., Yao, J., Zhou, C."Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes". Experimental and Therapeutic Medicine 9, no. 2 (2015): 451-455. https://doi.org/10.3892/etm.2014.2090
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