Histological observation of goblet cells following topical rebamipide treatment of the human ocular surface: A case report

Kase,Satoru; Shinohara,Toshiya; Kase,Manabu

doi:10.3892/etm.2014.2108

February-2015 Volume 9 Issue 2

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February-2015 Volume 9 Issue 2

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Case Report

Histological observation of goblet cells following topical rebamipide treatment of the human ocular surface: A case report

Authors:
- Satoru Kase
- Toshiya Shinohara
- Manabu Kase
View Affiliations / Copyright

Affiliations: Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan, Department of Surgical Pathology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan
Pages: 456-458
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Published online on: December 5, 2014

https://doi.org/10.3892/etm.2014.2108
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Abstract

The topical administration of rebamipide (Mucosta®), an antiulcer agent, clinically increases the mucin level of tear film. The aim of this study was to report the histological changes of goblet cells following the topical administration of rebamipide to a patient with nevus of the lacrimal caruncle. A 62-year-old male exhibited a pigmented nodule located in the lacrimal caruncle in the left eye. An excisional biopsy and subsequent surgical resection were conducted at the caruncle, prior to and three months after topical rebamipide administration. Histologically, a biopsy specimen revealed a pigmented nevus beneath the caruncle epithelium containing a few goblet cells [4 cells/high power field (HPF)]. A few nevus cells were present at the surgical margin. By contrast, the secondary resected specimen obtained three months after the initiation of topical rebamipide treatment revealed the epithelium and nevus, where numerous goblet cells were present (28 cells/HPF), and mucin-like substances were markedly secreted from the goblet cells. Topical rebamipide markedly increased the number of goblet cells and stimulated the secretion of mucin-like substances in the caruncular tissue of a human patient. These results suggest that topical rebamipide is useful in patients following surgery and/or biopsy to support tissue repair of the ocular surface.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Histological observation of goblet cells following topical rebamipide treatment of the human ocular surface: A case report

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Abstract

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