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Article

Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats

Retraction in: /10.3892/etm.2023.12333
  • Authors:
    • Peng Jiang
    • Qiong Ling
    • Hongbo Liu
    • Weifeng Tu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Huizhou Municipal Central Hospital, Huizhou, Guangdong 516001, P.R. China, Department of Anesthesiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510010, P.R. China, Department of Anesthesiology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China
  • Pages: 982-986
    |
    Published online on: December 19, 2014
       https://doi.org/10.3892/etm.2014.2149
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Abstract

Postoperative cognitive dysfunction (POCD) is common in elderly patients, and may persist or even evolve into Alzheimer's disease. It has been hypothesized that POCD is mediated by surgery‑induced inflammatory processes. As a pro‑inflammatory cytokine, the detailed role of interleukin (IL)‑6 in POCD remains largely unknown. In this study, laparotomy was used to mimic human abdominal surgery in aged Sprague‑Dawley rats. It was found that memory and learning were impaired following surgery, accompanied by the significant upregulation of the pro‑inflammatory cytokines tumor necrosis factor α (TNF‑α), IL‑1β, IL‑4, and IL‑6. Moreover, the intracisternal administration of the IL‑6 receptor (IL‑6R) antagonist (tocilizumab, also know as MRA) at the time of surgery notably attenuated the surgery‑induced cognitive deficit, and significantly inhibited the upregulated expression of pro‑inflammatory cytokines. Further investigation indicated that the intracisternal administration of MRA inhibited the activation of the NF‑κB signaling pathway in aged rats following surgery. In summary, the findings of this study suggest that IL‑6 plays a crucial role in POCD, and that IL‑6R antagonists may serve as novel agents for the prevention or treatment of POCD.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang P, Ling Q, Liu H and Tu W: Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333. Exp Ther Med 9: 982-986, 2015.
APA
Jiang, P., Ling, Q., Liu, H., & Tu, W. (2015). Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333. Experimental and Therapeutic Medicine, 9, 982-986. https://doi.org/10.3892/etm.2014.2149
MLA
Jiang, P., Ling, Q., Liu, H., Tu, W."Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333". Experimental and Therapeutic Medicine 9.3 (2015): 982-986.
Chicago
Jiang, P., Ling, Q., Liu, H., Tu, W."Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333". Experimental and Therapeutic Medicine 9, no. 3 (2015): 982-986. https://doi.org/10.3892/etm.2014.2149
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang P, Ling Q, Liu H and Tu W: Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333. Exp Ther Med 9: 982-986, 2015.
APA
Jiang, P., Ling, Q., Liu, H., & Tu, W. (2015). Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333. Experimental and Therapeutic Medicine, 9, 982-986. https://doi.org/10.3892/etm.2014.2149
MLA
Jiang, P., Ling, Q., Liu, H., Tu, W."Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333". Experimental and Therapeutic Medicine 9.3 (2015): 982-986.
Chicago
Jiang, P., Ling, Q., Liu, H., Tu, W."Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats Retraction in /10.3892/etm.2023.12333". Experimental and Therapeutic Medicine 9, no. 3 (2015): 982-986. https://doi.org/10.3892/etm.2014.2149
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