Elevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and staging

Zhang,Yan; Shen,Yucheng; Cao,Bin; Yan,Aiting; Ji,Haoming

doi:10.3892/etm.2014.2150

March-2015 Volume 9 Issue 3

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March-2015 Volume 9 Issue 3

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Article

Elevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and staging

Authors:
- Yan Zhang
- Yucheng Shen
- Bin Cao
- Aiting Yan
- Haoming Ji
View Affiliations / Copyright

Affiliations: Department of Oncology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China, Department of Pathology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China
Pages: 905-908
|
Published online on: December 19, 2014

https://doi.org/10.3892/etm.2014.2150
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Abstract

The aim of the present study was to investigate the potential roles of the androgen receptor (AR) and matrix metalloproteinase (MMP)-2 and MMP-9 in hepatocellular carcinoma (HCC) tissues and whether their expression could be used as a predictor of the invasion and stage of cancer. The expression levels of AR, MMP-2 and MMP-9 in HCC tissues and tissues adjacent to the tumor were measured by immunohistochemical staining assay. The expression rates of AR, MMP-2 and MMP-9 in the HCC tissue were 76.67, 73.33 and 76.67%, respectively, all of which were significantly higher than those in the tissues adjacent to the tumor. The expression of these proteins represents the local invasion and stage. AR, MMP-2 and MMP-9 expression levels in HCC tissues have the potential to be employed as predictors of the progression of local cancer invasion and the tumor stage.

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