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Article

Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome

  • Authors:
    • Ibrahim Sogut
    • Aysegul Oglakci
    • Kazim Kartkaya
    • Kevser Kusat Ol
    • Melis Savasan Sogut
    • Gungor Kanbak
    • Mine Erden Inal
  • View Affiliations / Copyright

    Affiliations: Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Bilim University, Istanbul 34394, Turkey, Department of Biochemistry, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir 26480, Turkey, Department of Genetics and Bioengineering, Yeditepe University, Istanbul 34755, Turkey
  • Pages: 1023-1027
    |
    Published online on: December 30, 2014
       https://doi.org/10.3892/etm.2014.2164
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Abstract

To the best of our knowledge, this is the first study concerning the effect of boric acid (BA) administration on fetal alcohol syndrome (FAS). In this study, the aim was to investigate prenatal alcohol‑induced oxidative stress on the cerebral cortex of newborn rat pups and assess the protective and beneficial effects of BA supplementation on rats with FAS. Pregnant rats were divided into three groups, namely the control, alcohol and alcohol + boric acid groups. As markers of alcohol‑induced oxidative stress in the cerebral cortex of the newborn pups, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were measured. Although the MDA levels in the alcohol group were significantly increased compared with those in the control group (P<0.05), the MDA level in the alcohol + boric acid group was shown to be significantly decreased compared with that in the alcohol group (P<0.01). The CAT activity of the alcohol + boric acid group was significantly higher than that in the alcohol group (P<0.05). The GPx activity in the alcohol group was decreased compared with that in the control group (P<0.05). These results demonstrate that alcohol is capable of triggering damage to membranes of the cerebral cortex of rat pups and BA could be influential in antioxidant mechanisms against oxidative stress resulting from prenatal alcohol exposure.
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1 

Abel EL and Hannigan JH: Maternal risk factors in fetal alcohol syndrome: provocative and permissive influences. Neurotoxicol Teratol. 17:445–462. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Lemoine P, Harousseau H, Borteyru JP and Menuet JC: Children of alcoholic parents - observed anomalies: discussion of 127 cases. Ther Drug Monit. 25:132–136. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Jones KL and Smith DW: Recognition of the fetal alcohol syndrome in early infancy. Lancet. 302:999–1001. 1973. View Article : Google Scholar : PubMed/NCBI

4 

May PA, Gossage JP, Kalberg WO, et al: Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Dev Disabil Res Rev. 15:176–192. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Burd L and Martsolf JT: Fetal alcohol syndrome: diagnosis and syndromal variability. Physiol Behav. 46:39–43. 1989. View Article : Google Scholar : PubMed/NCBI

6 

Ahveninen J, Escera C, Polo MD, Grau C and Jääskeläinen IP: Acute and chronic effects of alcohol on preattentive auditory processing as reflected by mismatch negativity. Audiol Neurootol. 5:303–311. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Sampson PD, Streissguth AP, Bookstein FL and Barr HM: On categorizations in analyses of alcohol teratogenesis. Environ Health Perspect. 108(Suppl 3): 421–428. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Abel EL and Sokol RJ: A revised conservative estimate of the incidence of FAS and its economic impact. Alcohol Clin Exp Res. 15:514–524. 1991. View Article : Google Scholar : PubMed/NCBI

9 

Fast DK, Conry J and Loock CA: Identifying fetal alcohol syndrome among youth in the criminal justice system. J Dev Behav Pediatr. 20:370–372. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Cornelli U: Antioxidant use in nutraceuticals. Clin Dermatol. 27:175–194. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Brocardo PS, Gil-Mohapel J and Christie BR: The role of oxidative stress in fetal alcohol spectrum disorders. Brain Res Rev. 67:209–225. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Sies H: Oxidative stress: from basic research to clinical application. Am J Med. 91(Suppl 3): 31S–38S. 1991. View Article : Google Scholar : PubMed/NCBI

13 

Cohen-Kerem R and Koren G: Antioxidants and fetal protection against ethanol teratogenicity. I Review of the experimental data and implications to humans. Neurotoxicol Teratol. 25:1–9. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Bandyopadhyay U, Das D and Banerjee RK: Reactive oxygen species: Oxidative damage and pathogenesis. Current Sci. 77:658–666. 1999.

15 

Nielsen FH: Is boron nutritionally relevant? Nutr Rev. 66:183–191. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Hunt CD: Boron. Encyclopedia of Dietary Supplements. 1st edition. Coates PM, Blackman MR, Cragg GM, Levine M, Moss J and White JD: Marcel Dekker; New York, NY: pp. 55–65. 2005

17 

Altieri S, Bortolussi S, Bruschi P, et al: Neutron autoradiography imaging of selective boron uptake in human metastatic tumours. Appl Radiat Isot. 66:1850–1855. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Hunt CD and Idso JP: Dietary boron as a physiological regulator of the normal inflammatory response: A review and current research progress. J Trace Elem Exp Med. 12:221–233. 1999. View Article : Google Scholar

19 

Ince S, Keles H, Erdogan M, Hazman O and Kucukkurt I: Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice. Drug Chem Toxicol. 35:285–292. 2012. View Article : Google Scholar

20 

Turkez H, Geyikoğlu F, Tatar A, Keleş S and Ozkan A: Effects of some boron compounds on peripheral human blood. Z Naturforsch C. 62:889–896. 2007. View Article : Google Scholar

21 

Ince S, Kucukkurt I, Cigerci IH, Fatih Fidan A and Eryavuz A: The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J Trace Elem Med Biol. 24:161–164. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Uzbay IT and Kayaalp SO: A modified liquid diet of chronic ethanol administration: validation by ethanol withdrawal syndrome in rats. Pharmacol Res. 31:37–42. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Jiang Q, Hu Y, Wu P, et al: Prenatal alcohol exposure and the neuroapoptosis with long-term effect in visual cortex of mice. Alcohol Alcohol. 42:285–290. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Ohkawa H, Ohishi N and Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358. 1979. View Article : Google Scholar : PubMed/NCBI

25 

Winterbourn CC, Hawkins RE, Brian M and Carrell RW: The estimation of red cell superoxide dismutase activity. J Lab Clin Med. 85:337–341. 1975.PubMed/NCBI

26 

Beutler E: Catalase. Red Cell Metabolism A Manual of Biochemical Methods. 3rd edition. Grune and Stratton; New York, NY: pp. 105–106. 1982

27 

Paglia DE and Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 70:158–169. 1967.PubMed/NCBI

28 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976. View Article : Google Scholar : PubMed/NCBI

29 

Sogut I and Kanbak G: In vitro effects of ethanol with aspirin on rat brain synaptosomes: the potential protective role of betaine. Int J Neurosci. 120:774–783. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Zimatkin SM and Deitrich RA: Ethanol metabolism in the brain. Addict Biol. 2:387–400. 1997. View Article : Google Scholar

31 

Bora PS and Lange LG: Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esthers. Alcohol Clin Exp Res. 17:28–30. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Wu D and Cederbaum AI: Alcohol, oxidative stress, and free radical damage. Alcohol Res Health. 27:277–284. 2003.

33 

Hagihara M, Nishigaki I, Maseki M and Yagi K: Age-dependent changes in lipid peroxide levels in the lipoprotein fractions of human serum. J Gerontol. 39:269–272. 1984. View Article : Google Scholar : PubMed/NCBI

34 

Amini SA, Dunstan RH, Dunkley PR and Murdoch RN: Oxidative stress and the fetotoxicity of alcohol consumption during pregnancy. Free Radic Biol Med. 21:357–365. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Smith AM, Zeve DR, Grisel JJ and Chen WJ: Neonatal alcohol exposure increases malondialdehyde (MDA) and glutathione (GSH) levels in the developing cerebellum. Brain Res Dev Brain Res. 160:231–238. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Brocardo PS, Boehme F, Patten A, Cox A, Gil-Mohapel J and Christie BR: Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of voluntary physical exercise. Neuropharmacology. 62:1607–1618. 2012. View Article : Google Scholar

37 

Shivakumar BR, Anandatheerthavarada HK and Ravindranath V: Free radical scavenging systems in developing rat brain. Int J Dev Neurosci. 9:181–185. 1991. View Article : Google Scholar : PubMed/NCBI

38 

Bailey SM, Patel VB, Young TA, Asayama K and Cunningham CC: Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin Exp Res. 25:726–733. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Pawa S and Ali S: Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem Biol Interact. 160:89–98. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Nielsen FH: Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. FASEB J. 5:2661–2667. 1991.PubMed/NCBI

41 

Hunt CD: The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect. 102(Suppl 7): 35–43. 1994. View Article : Google Scholar : PubMed/NCBI

42 

Weir RJ Jr and Fisher RS: Toxicologic studies on borax and boric acid. Toxicol Appl Pharmacol. 23:351–364. 1972. View Article : Google Scholar : PubMed/NCBI

43 

Nielsen FH: Boron deprivation decreases liver S-adenosylmethionine and spermidine and increases plasma homocysteine and cysteine in rats. J Trace Elem Med Biol. 23:204–213. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Stickel F, Choi SW, Kim YI, et al: Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res. 24:259–264. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Driscoll CD, Streissguth AP and Riley EP: Prenatal alcohol exposure: comparability of effects in humans and animal models. Neurotoxicol Teratol. 12:231–237. 1990. View Article : Google Scholar : PubMed/NCBI

46 

Mohora MBL, Boghianu L, Muscurel C, et al: Effects of boric acid on redox status in the rat liver. Romanian J Biophys. 12:77–82. 2002.

47 

Hamby-Mason R, Chen JJ, Schenker S, Perez A and Henderson GI: Catalase mediates acetaldehyde formation from ethanol in fetal and neonatal rat brain. Alcohol Clin Exp Res. 21:1063–1072. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G and Inal ME: Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Exp Ther Med 9: 1023-1027, 2015.
APA
Sogut, I., Oglakci, A., Kartkaya, K., Ol, K.K., Sogut, M.S., Kanbak, G., & Inal, M.E. (2015). Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Experimental and Therapeutic Medicine, 9, 1023-1027. https://doi.org/10.3892/etm.2014.2164
MLA
Sogut, I., Oglakci, A., Kartkaya, K., Ol, K. K., Sogut, M. S., Kanbak, G., Inal, M. E."Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome". Experimental and Therapeutic Medicine 9.3 (2015): 1023-1027.
Chicago
Sogut, I., Oglakci, A., Kartkaya, K., Ol, K. K., Sogut, M. S., Kanbak, G., Inal, M. E."Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1023-1027. https://doi.org/10.3892/etm.2014.2164
Copy and paste a formatted citation
x
Spandidos Publications style
Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G and Inal ME: Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Exp Ther Med 9: 1023-1027, 2015.
APA
Sogut, I., Oglakci, A., Kartkaya, K., Ol, K.K., Sogut, M.S., Kanbak, G., & Inal, M.E. (2015). Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. Experimental and Therapeutic Medicine, 9, 1023-1027. https://doi.org/10.3892/etm.2014.2164
MLA
Sogut, I., Oglakci, A., Kartkaya, K., Ol, K. K., Sogut, M. S., Kanbak, G., Inal, M. E."Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome". Experimental and Therapeutic Medicine 9.3 (2015): 1023-1027.
Chicago
Sogut, I., Oglakci, A., Kartkaya, K., Ol, K. K., Sogut, M. S., Kanbak, G., Inal, M. E."Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1023-1027. https://doi.org/10.3892/etm.2014.2164
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