Cutaneous manifestations in a patient with chronic lymphocytic leukemia involving the head, neck and distal extremities

Lu,Chongrong; Li,Li; Qiao,Qiaohua; Liu,Guozhen; Fang,Lizheng

doi:10.3892/etm.2015.2178

March-2015 Volume 9 Issue 3

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March-2015 Volume 9 Issue 3

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Article Open Access

Cutaneous manifestations in a patient with chronic lymphocytic leukemia involving the head, neck and distal extremities

Authors:
- Chongrong Lu
- Li Li
- Qiaohua Qiao
- Guozhen Liu
- Lizheng Fang
View Affiliations / Copyright

Affiliations: Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China, Family Medicine Residency Program, Genesys Regional Medical Center, Grand Blanc, MI 48439, USA

Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 877-879
|
Published online on: January 13, 2015

https://doi.org/10.3892/etm.2015.2178
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Abstract

Chronic lymphocytic leukemia (CLL) infiltrating the skin is uncommon and can present in many different ways. The present study reports a case of CLL infiltrating multiple body areas. A 57‑year‑old male with a 10‑year history of subclinical B‑cell chronic lymphocytic leukemia (B‑CLL) presented with skin hypertrophic changes of the ears, eyebrows, tip of the nose, toes and fingers. In addition, the patient had erythematous plaques on the buttocks. Histopathology revealed a lymphocytic infiltrate. The patient rejected the recommended chemotherapy and, following a three‑year follow‑up, remained alive with mildly aggravated symptoms. It has previously been reported that infiltrative CLL can involve the head and neck; however, involvement of multiple body areas, particularly toes and fingers is rare. This case highlights the importance of considering leukemia cutis in patients with underlying CLL who present with unusual clinical features.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cutaneous manifestations in a patient with chronic lymphocytic leukemia involving the head, neck and distal extremities

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