Macrolide therapy in cryptogenic organizing pneumonia: A case report and literature review

Ding,Qun‑Li; Lv,Dan; Wang,Bi‑Jiong; Zhang,Qiao‑Li; Yu,Yi‑Ming; Sun,Shi‑Fang; Chen,Zhong‑Bo; Ma,Hong‑Ying; Deng,Zai‑Chun

doi:10.3892/etm.2015.2183

March-2015 Volume 9 Issue 3

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March-2015 Volume 9 Issue 3

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Case Report

Macrolide therapy in cryptogenic organizing pneumonia: A case report and literature review

Authors:
- Qun‑Li Ding
- Dan Lv
- Bi‑Jiong Wang
- Qiao‑Li Zhang
- Yi‑Ming Yu
- Shi‑Fang Sun
- Zhong‑Bo Chen
- Hong‑Ying Ma
- Zai‑Chun Deng
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315020, P.R. China
Pages: 829-834
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Published online on: January 15, 2015

https://doi.org/10.3892/etm.2015.2183
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Abstract

Cryptogenic organizing pneumonia (COP) is a pulmonary disorder associated with nonspecific clinical presentations. The macrolide class of antimicrobial agents is widely used to treat infectious and inflammatory respiratory diseases in humans. The present study reports a case of COP that was effectively treated with azithromycin in combination with glucocorticoid. A literature review of similar cases is also presented. It was found that all COP patients in the literature received macrolide treatment, including six cases with unknown clinical outcomes. For the remaining 29 patients, 20 patients initially received the macrolide as a single therapy and 4/5 of them (16 cases) were cured with a treatment time of 3‑14 months, while 1/5 (4 cases) showed no improvement after treatment for 1 month and were switched to a glucocorticoid or combination treatment with a glucocorticoid, after which the disease was finally well‑controlled. Side‑effects of macrolide were rare. Based on this analysis, it is recommended that macrolides can be used as a first‑line therapy in patients with mild COP. For patients with recurrent COP, it is suggested that macrolides should be used as an adjunctive therapy with other treatments, such as a glucocorticoid.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Macrolide therapy in cryptogenic organizing pneumonia: A case report and literature review

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