Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1

  • Authors:
    • Qiang Gao
    • Nusheng Liang
  • View Affiliations / Copyright

    Affiliations: Physician Department, Health Service Center, Nyalam, Tibet 858300, P.R. China, Department of Gastroenterology, First Hospital of Tianjin, Tianjin 300193, P.R. China
  • Pages: 947-954
    |
    Published online on: January 20, 2015
       https://doi.org/10.3892/etm.2015.2191
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Integrated traditional Chinese medicine (ITCM) is known to improve health in patients with acute pancreatitis (AP); however, the molecular mechanisms underlying this effect are unknown. AP is associated with the expression of PRSS1 and SPINK1. Thus, the present study aimed to investigate whether ITCM was able to ameliorate AP by regulating the expression levels of protein, serine 1 (PRSS1) and serine peptidase inhibitor, Kazal type 1 (SPINK1). A total of 100 AP patients were divided at random into two groups. The treatment group were treated externally with a herbal ITCM preparation, while the control group received a routine placebo treatment. The mRNA and protein expression levels of PRSS1 and Spink1 were subsequently compared between the two groups. The results revealed that the health of the patients who had received ITCM improved significantly when compared with the control group patients (P<0.05). In addition, the expression levels of PRSS1 and SPINK1 were found to be lower in the treatment group when compared with the control group (P<0.05). Therefore, ITCM exhibited a significant therapeutic effect on AP and produced no side effects since the treatment was applied externally. ITCM may ameliorate AP by downregulating the expression of PRSS1 and SPINK1; thus, should be considered as a potential therapy for the development of drugs against AP.
View Figures

Figure 1

Figure 2

View References

1 

Matta A, Tandra PK, Cichowski E and Reddymasu SC: Acute necrotising pancreatitis: a late and fatal complication of pancreaticoduodenal arterial embolisation. BMJ Case Rep. bcr20142041972014. View Article : Google Scholar : PubMed/NCBI

2 

Rana SS, Sharma V, Sharma R and Bhasin DK: An unusual complication of acute necrotising pancreatitis detected by endoscopic ultrasound. JOP. 15:276–277. 2014.PubMed/NCBI

3 

Ambiru S, Furuyama N, Aono M, et al: Hyperbaric oxygen therapy for the treatment of postoperative paralytic ileus and adhesive intestinal obstruction associated with abdominal surgery: experience with 626 patients. Hepatogastroenterology. 54:1925–1929. 2007.

4 

Sheikh I, Fontenot E, Waghray N, et al: The role of nonsteroidal anti-inflammatory drugs in the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis. JOP. 15:219–224. 2014.PubMed/NCBI

5 

Sit M, Aktas G, Yilmaz EE, et al: Effects of the inflammatory response on serum omentin levels in early acute and chronic pancreatitis. Clin Ter. 165:e148–e152. 2014.PubMed/NCBI

6 

Shalimov SA, Popov ON, Dubitskiĭ AE and Lifshits IuZ: Direct thermometry of the pancreas in the postoperative period. Vestn Khir Im I I Grek. 132:36–39. 1984.(In Russian). PubMed/NCBI

7 

Mascolo N, Izzo AA, Ligresti A, et al: The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB J. 16:1973–1975. 2002.PubMed/NCBI

8 

Elder AS, Saccone GT, Bersten AD and Dixon DL: Evaluation of lung injury and respiratory mechanics in a rat model of acute pancreatitis complicated with endotoxin. Pancreatology. 12:240–247. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Fujita T: Endotoxin as a trigger of alcoholic pancreatitis. Gastroenterology. 134:640–641. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Verma R, Dhamija R, Ross SC, Batts DH and Loehrke ME: Symbiotic bacteria induced necrotizing pancreatitis. JOP. 11:474–476. 2010.PubMed/NCBI

11 

Zhang X, Tian H, Wu C, et al: Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis. Pancreas. 38:732–738. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Cuthbertson CM and Christophi C: Disturbances of the microcirculation in acute pancreatitis. Br J Surg. 93:518–530. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Yang XN, Guo J, Lin ZQ, et al: The study on causes of death in fulminant pancreatitis at early stage and late stage. Sichuan Da Xue Xue Bao Yi Xue Ban. 42:686–690. 2011.(In Chinese). PubMed/NCBI

14 

Yuan Z, Meyerholz DK, Twait EC, et al: Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis. J Gastrointest Surg. 15:1670–1678. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Tsuji Y, Takahashi N, Fletcher JG, et al: Subtraction color map of contrast-enhanced and unenhanced CT for the prediction of pancreatic necrosis in early stage of acute pancreatitis. AJR Am J Roentgenol. 202:W349–W356. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Garip G, Sarandöl E and Kaya E: Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis. World J Gastroenterol. 19:8065–8070. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Popa D: Treatment in severe acute pancreatitis - still a reason of debate. J Med Life. 6:486–490. 2013.

18 

Ge HY and Chen B: Clinical observation of acute pancreatitis treated with acupoint application combined with medicine. Zhongguo Zhen Jiu. 32:602–604. 2012.(In Chinese). PubMed/NCBI

19 

Bossi A, Romeo G and Pezzoli A: Side-effects, structure, and H2-receptor antagonists. Lancet. 339:13661992. View Article : Google Scholar : PubMed/NCBI

20 

Xia Q and Deng LH: Hot issues on the treatment of severe acute pancreatitis by integrated traditional Chinese and Western medicine. Sichuan Da Xue Xue Bao Yi Xue Ban. 44:962–965. 2013.(In Chinese).

21 

Wan MH, Yao J, Li J, et al: The effectiveness of purgation and electroacupuncture in extrahepatic bile duct stone complicated with acute biliary pancreatitis: management of biliary stone pancreatitis through traditional Chinese medicine. Pancreas. 40:483–484. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Tang Y, Liao Y, Kawaguchi-Sakita N, et al: Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats. J Hepatobiliary Pancreat Sci. 18:551–558. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Solomon S, Whitcomb DC and LaRusch J: PRSS1-related hereditary pancreatitis. GeneReviews®. Pagon RA, Adam MP, Ardinger HH, et al: University of Washington; Seattle, WA: 2012

24 

Sánchez-Ramírez CA, Flores-Martínez SE, García-Zapién AG, et al: Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis. Pancreas. 41:707–711. 2012.PubMed/NCBI

25 

Tukiainen E, Kylänpää ML, Kemppainen E, et al: Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis. Pancreas. 30:239–242. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Lee YJ, Kim KM, Choi JH, et al: High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. J Pediatr Gastroenterol Nutr. 52:478–481. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Sobczyńska-Tomaszewska A, Bak D, Oralewska B, et al: Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis. J Pediatr Gastroenterol Nutr. 43:299–306. 2006. View Article : Google Scholar

28 

Kiriyama S, Gabata T, Takada T, et al: New diagnostic criteria of acute pancreatitis. J Hepatobiliary Pancreat Sci. 17:24–36. 2010. View Article : Google Scholar

29 

Gubergrits N, Golubova O, Lukashevich G and Fomenko P: Elevated serum amylase in patients with chronic pancreatitis: acute attack or macroamylasemia? Pancreatology. 14:114–116. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Wojtuń S and Gil J: Utility of amylase serum and urine activity in acute biliary pancreatitis treated with biliary sphincterotomy. Pol Merkur Lekarski. 22:381–384. 2007.(In Polish).

31 

Banks PA, Bollen TL, Dervenis C, et al; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 62:102–111. 2013. View Article : Google Scholar

32 

Li YC, Dong L, Jia A, Chang XM and Xue H: Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization. Nan Fang Yi Ke Da Xue Xue Bao. 26:541–544. 2006.(In Chinese). PubMed/NCBI

33 

Zhuang WJ and Qian C: Treatment of infected deciduous root canal with Samyan (traditional Chinese medicine) paste: Clinical analysis. Shanghai Kou Qiang Yi Xue. 6:1851997.(In Chinese).

34 

Xue QM, Li N, Xue P, Wang CW and Wen Q: Therapeutic effects of electroacupuncture at ST36 acupoint on sodium-taurocholate-induced severe acute pancreatitis. Chin J Integr Med. 20:695–700. 2014. View Article : Google Scholar

35 

Saito Y, Emura F, Matsuda T, et al: A new sinker-assisted endoscopic submucosal dissection for colorectal cancer. Gastrointest Endosc. 62:297–301. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Zhao J, Liao Q, Zhao Y and Hu Y: Mortality indicators and risk factors for intra-abdominal hypertension in severe acute pancreatitis. Int Surg. 99:252–257. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Vipperla K, Papachristou GI, Easler J, et al: Risk of and factors associated with readmission after a sentinel attack of acute pancreatitis. Clin Gastroenterol Hepatol. May 9–2014.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

38 

Zeng YB, Zhan XB, Guo XR, et al: Risk factors for pancreatic infection in patients with severe acute pancreatitis: an analysis of 163 cases. J Dig Dis. 15:377–385. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Jin J, Yu YH, Zhong M and Zhang GW: Analyzing and identifying risk factors for acute pancreatitis with different etiologies in pregnancy. J Matern Fetal Neonatal Med. June 5;1–5. 2014.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

40 

Tamasaki A, Nishimura Y, Kondo N, et al: Risk factors for acute pancreatitis in patients with severe motor and intellectual disabilities. Pediatr Int. 56:240–243. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Hong S, Qiwen B, Ying J, Wei A and Chaoyang T: Body mass index and the risk and prognosis of acute pancreatitis: a meta-analysis. Eur J Gastroenterol Hepatol. 23:1136–1143. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Shen HN, Wang WC, Lu CL and Li CY: Effects of gender on severity, management and outcome in acute biliary pancreatitis. PLoS One. 8:e575042013. View Article : Google Scholar : PubMed/NCBI

43 

Fu P, Yuan AH, Wang CH, Li X and Wu HY: Alcohol-induced severe acute pancreatitis followed by hemolytic uremic syndrome managed with continuous renal replacement therapy. BMC Nephrol. 15:12014. View Article : Google Scholar : PubMed/NCBI

44 

Nikkola J, Räty S, Laukkarinen J, et al: Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction. Alcohol Alcohol. 48:483–486. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Müller S, Kaiser H, Krüger B, et al: Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice. PLoS One. 9:e944942014. View Article : Google Scholar : PubMed/NCBI

46 

Okamura D, Starr ME, Lee EY, et al: Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis. Aging Cell. 11:760–769. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Akesson A, Andersen LF, Kristjánsdóttir AG, et al: Health effects associated with foods characteristic of the Nordic diet: a systematic literature review. Food Nutr Res. 572013.

48 

Overby NC, Sonestedt E, Laaksonen DE and Birgisdottir BE: Dietary fiber and the glycemic index: a background paper for the Nordic Nutrition Recommendations 2012. Food Nutr Res. 57:2013. View Article : Google Scholar : PubMed/NCBI

49 

Knaan T, Endevelt R and Singer P: Evaluating the validity of the ‘categories method’: A new method for self-report assessment of daily calorie intake: A pilot study. Can J Diabetes. 37(Suppl 2): S2832013. View Article : Google Scholar

50 

Pelaez-Luna M, Robles-Diaz G, Canizales-Quinteros S and Tusie-Luna MT: PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis. World J Gastroenterol. 20:11788–11792. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Roncati L, Gualandri G, Fortuni G and Barbolini G: Sudden death and lipomatous infiltration of the heart involved by fat necrosis resulting from acute pancreatitis. Forensic Sci Int. 217:e19–e22. 2012. View Article : Google Scholar

52 

Chen H, Li F, Jia JG, et al: Effects of traditional Chinese medicine on intestinal mucosal permeability in early phase of severe acute pancreatitis. Chin Med J (Engl). 123:1537–1542. 2010.

53 

Zhang MJ, Zhang GL, Yuan WB, Ni J and Huang LF: Treatment of abdominal compartment syndrome in severe acute pancreatitis patients with traditional Chinese medicine. World J Gastroenterol. 14:3574–3578. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Athwal T, Huang W, Mukherjee R, et al: Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death. Cell Death Dis. 5:e11652014. View Article : Google Scholar : PubMed/NCBI

55 

Wang J, Ohmuraya M, Suyama K, et al: Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression. Lab Invest. 90:654–664. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Corleto VD, Gambardella S, Gullotta F, et al: New PRSS1 and common CFTR mutations in a child with acute recurrent pancreatitis, could be considered an ‘Hereditary’ form of pancreatitis? BMC Gastroenterol. 10:1192010. View Article : Google Scholar

57 

Ohmuraya M and Yamamura K: Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases. Exp Anim. 60:433–444. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Rai P, Sharma A, Gupta A and Aggarwal R: Frequency of SPINK1 N34S mutation in acute and recurrent acute pancreatitis. J Hepatobiliary Pancreat Sci. 21:663–668. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Tremblay K, Dubois-Bouchard C, Brisson D and Gaudet D: Association of CTRC and SPINK1 gene variants with recurrent hospitalizations for pancreatitis or acute abdominal pain in lipoprotein lipase deficiency. Front Genet. 5:902014. View Article : Google Scholar : PubMed/NCBI

60 

Terlizzi V, De Gregorio F, Sepe A, et al: Brand new SPINK1 and CFTR mutations in a child with acute recurrent pancreatitis: a case report. Minerva Pediatr. 65:669–672. 2013.PubMed/NCBI

61 

Jøergensen MT, Brusgaard K, Novovic S, et al: Is the SPINK1 variant p. N34S overrepresented in patients with acute pancreatitis? Eur J Gastroenterol Hepatol. 24:309–315. 2012. View Article : Google Scholar

62 

Baudry C, Rebours V, Houillier P, et al: Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. Pancreas. 39:420–421. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Aoun E, Muddana V, Papachristou GI and Whitcomb DC: SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. Am J Gastroenterol. 105:446–451. 2010. View Article : Google Scholar

64 

Liu XB, Jiang JM, Huang ZW, et al: Clinical study on the treatment of severe acute pancreatitis by integrated traditional Chinese medicine and Western medicine. J Sichuan University (medical science edition). 35:204–208. 2004.(In Chinese).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao Q and Liang N: Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1. Exp Ther Med 9: 947-954, 2015.
APA
Gao, Q., & Liang, N. (2015). Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1. Experimental and Therapeutic Medicine, 9, 947-954. https://doi.org/10.3892/etm.2015.2191
MLA
Gao, Q., Liang, N."Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1". Experimental and Therapeutic Medicine 9.3 (2015): 947-954.
Chicago
Gao, Q., Liang, N."Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1". Experimental and Therapeutic Medicine 9, no. 3 (2015): 947-954. https://doi.org/10.3892/etm.2015.2191
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Q and Liang N: Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1. Exp Ther Med 9: 947-954, 2015.
APA
Gao, Q., & Liang, N. (2015). Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1. Experimental and Therapeutic Medicine, 9, 947-954. https://doi.org/10.3892/etm.2015.2191
MLA
Gao, Q., Liang, N."Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1". Experimental and Therapeutic Medicine 9.3 (2015): 947-954.
Chicago
Gao, Q., Liang, N."Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1". Experimental and Therapeutic Medicine 9, no. 3 (2015): 947-954. https://doi.org/10.3892/etm.2015.2191
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team