Open Access

Bu Shen Huo Xue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model

  • Authors:
    • Xin Gong
    • Jiaoying Lou
    • Qiudan Lu
    • Haitao Huang
    • Zhe Jin
  • View Affiliations

  • Published online on: January 20, 2015     https://doi.org/10.3892/etm.2015.2193
  • Pages: 751-757
  • Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Leukemia‑inhibitory factor (LIF) and Angiopoietin‑2 (Ang‑2) are important factors in fertility. In the present study, it was investigated whether Bu Shen Huo Xue Decoction (BSHXD) prevents controlled ovarian hyperstimulation (COH) treatment‑induced changes in endometrial LIF and Ang‑2 expression and whether it has an effect on the number of implantation sites and live births in rats. Uteri were collected on day (D) 3, 4 and 5 of pregnancy, and LIF and Ang‑2 protein and mRNA expression were detected using western blot analysis and quantitative polymerase chain reaction. On pregnancy D10, the average number of implantation sites was observed. The number of live births from each group was recorded. The results indicated that BSHXD treatment markedly increased the number of live births by restoring endometrial LIF expression and the implantation capacity in the COH rat model. In addition, no association was identified between LIF and Ang‑2 expression. Therefore, this suggests that BSHXD may be useful for female reproduction.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gong X, Lou J, Lu Q, Huang H and Jin Z: Bu Shen Huo Xue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model. Exp Ther Med 9: 751-757, 2015.
APA
Gong, X., Lou, J., Lu, Q., Huang, H., & Jin, Z. (2015). Bu Shen Huo Xue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model. Experimental and Therapeutic Medicine, 9, 751-757. https://doi.org/10.3892/etm.2015.2193
MLA
Gong, X., Lou, J., Lu, Q., Huang, H., Jin, Z."Bu Shen Huo Xue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model". Experimental and Therapeutic Medicine 9.3 (2015): 751-757.
Chicago
Gong, X., Lou, J., Lu, Q., Huang, H., Jin, Z."Bu Shen Huo Xue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model". Experimental and Therapeutic Medicine 9, no. 3 (2015): 751-757. https://doi.org/10.3892/etm.2015.2193