Association between brain metastasis from lung cancer and the serum level of myelin basic protein

Liu,Wei; Zhao,Jing; Wei,Yujuan

doi:10.3892/etm.2015.2195

March-2015 Volume 9 Issue 3

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March-2015 Volume 9 Issue 3

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Article

Association between brain metastasis from lung cancer and the serum level of myelin basic protein

Authors:
- Wei Liu
- Jing Zhao
- Yujuan Wei
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Affiliations: Department of Respiratory Medicine, The People's Hospital of Rizhao, Rizhao, Shandong 276826, P.R. China
Pages: 1048-1050
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Published online on: January 20, 2015

https://doi.org/10.3892/etm.2015.2195
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Abstract

The aim of the present study was to determine the association between the expression of myelin basic protein in the serum and the metastasis of lung cancer to the brain. A total of 68 lung cancer patients, treated in the Department of Respiratory Medicine of the People's Hospital of Rizhao (Rizhao, China), were divided into two groups, those with brain metastasis (32 cases) and those without brain metastasis (36 cases). The expression levels of myelin basic protein were measured for all the patients. The results indicated that the expression levels of myelin basic protein in the brain metastasis group were significantly higher when compared with those in the group without metastasis (P<0.05). However, there was no statistically significant correlation between the size of the brain metastasis and the expression levels of myelin basic protein (P>0.05). Furthermore, no statistically significant difference was found in the average level of myelin basic protein between the two subgroups of patients with brain tumor diameters of >1.5 cm and <1.5 cm (P>0.05). Therefore, the results demonstrated a statistically significant correlation between the expression of myelin basic protein in the serum and the metastasis of lung cancer to the brain. Myelin basic protein may thus prove useful in the early diagnosis of brain metastases in lung cancer patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association between brain metastasis from lung cancer and the serum level of myelin basic protein

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