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March-2015 Volume 9 Issue 3

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Article

Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis

  • Authors:
    • Yong Zhen
    • Nan Zhang
    • Liang He
    • Linhai Shen
    • Kaixuan Yan
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, P.R. China
  • Pages: 1080-1084
    |
    Published online on: January 21, 2015
       https://doi.org/10.3892/etm.2015.2198
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Abstract

The aim of the present study was to assess the effectiveness and safety of endovascular interventional therapy, which is mechanical clot disruption combined with intrasinus thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA), for severe cerebral venous sinus thrombosis (CVST). The records of eight patients with CVST confirmed by computed tomography, magnetic resonance imaging (MRI), magnetic resonance venography (MRV) and/or digital subtraction angiography were analyzed. Of the eight cases, the Glasgow Coma Scale (GCS) scores were between 4 and 9 with a mean value of 8.3±2.7. All the patients had venous infarction and two cases had intracranial hemorrhagic infarcts. Mechanical clot destruction combined with intrasinus thrombolytic therapy with rt-PA was performed under general anesthesia. Intravenous heparin therapy and intracerebral pressure control were applied during this period. One patient succumbed and the other seven patients showed good treatment efficacy. The GCS scores of the seven patients reverted to 15 upon discharge from the Northern Jiangsu People's Hospital (Yangzhou, China). With regard to the modified Rankin score of the seven patients three months following surgery, six patients scored 0 and one patient scored 1. MRI and MRV follow‑up examinations were performed for 3‑15 months. Complete recanalization of the criminal sinus, which refer to the sinus attributable to the infarction or hemorrhage, was observed in five cases and partial recanalization was observed in two cases. Symptoms were monitored for 3‑24 months and no recurrence was observed. Therefore, mechanical thrombectomy combined with intrasinus thrombolytic therapy with rt-PA is safe and effective for patients with severe CVST.
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1 

Agostoni E, Aliprandi A and Longoni M: Cerebral venous thrombosis. Expert Rev Neurother. 9:553–564. 2009. View Article : Google Scholar : PubMed/NCBI

2 

van den Bergh WM, van der Schaaf I and van Gijn J: The spectrum of presentations of venous infarction caused by deep cerebral vein thrombosis. Neurology. 65:192–196. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Bousser MG and Ferro JM: Cerebral venous thrombosis: an update. Lancet Neurol. 6:162–170. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Kimber J: Cerebral venous sinus thrombosis. QJM. 95:137–142. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Furie KL, Kasner SE, Adams RJ, et al: Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke. 42:227–276. 2011. View Article : Google Scholar

6 

Wasay M, Bakshi R, Bobustuc G, et al: Cerebral venous thrombosis: analysis of a multicenter cohort from the United States. J Stroke Cerebrovasc Dis. 17:49–54. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Ferro JM, Canhão P, Stam J, Bousser MG and Barinagarrementeria F; ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 35:664–670. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Borhani Haghighi A, Edgell RC, Cruz-Flores S, et al: Mortality of cerebral venous-sinus thrombosis in a large national sample. Stroke. 43:262–264. 2012. View Article : Google Scholar

9 

Guo XB, Guan S, Fan Y and Song LJ: Local thrombolysis for severe cerebral venous sinus thrombosis. AJNR Am J Neuroradiol. 33:1187–1190. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Rahman M, Velat GJ, Hoh BL and Mocco J: Direct thrombolysis for cerebral venous sinus thrombosis. Neurosurg Focus. 27:E72009. View Article : Google Scholar : PubMed/NCBI

11 

Einhäupl K, Stam J, Bousser MG, et al: EFNS guideline on the treatment of cerebral venous and sinus thrombosis in adult patients. Eur J Neurol. 17:1229–1235. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Saposnik G, Barinagarrementeria F, Brown RD Jr, et al: Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 42:1158–1192. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Einhäupl KM, Villringer A, Meister W, et al: Heparin treatment in sinus venous thrombosis. Lancet. 338:597–600. 1991. View Article : Google Scholar : PubMed/NCBI

14 

de Bruijn SF and Stam J: Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke. 30:484–488. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Coutinho JM, de Bruijn SF, deVeber G and Stam J: Anticoagulation for cerebral venous sinus thrombosis. Stroke. 43:e41–42. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Chow K, Gobin YP, Saver J, Kidwell C, Dong P and Viñuela F: Endovascular treatment of dural sinus thrombosis with rheolytic thrombectomy and intra-arterial thrombolysis. Stroke. 31:1420–1425. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Frey JL, Muro GJ, McDougall CG, Dean BL and Jahnke HK: Cerebral venous thrombosis: combined intrathrombus rtPA and intravenous heparin. Stroke. 30:489–494. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Smith AG, Cornblath WT and Deveikis JP: Local thrombolytic therapy in deep cerebral venous thrombosis. Neurology. 48:1613–1619. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Renowden SA, Oxbury J and Molyneux AJ: Case report: venous sinus thrombosis: the use of thrombolysis. Clin Radiol. 52:396–399. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Kim SY and Suh JH: Direct endovascular thrombolytic therapy for dural sinus thrombosis: infusion of alteplase. AJNR Am J Neuroradiol. 18:639–645. 1997.PubMed/NCBI

21 

Théaudin M, Crassard I, Bresson D, et al: Should decompressive surgery be performed in malignant cerebral venous thrombosis?: a series of 12 patients. Stroke. 41:727–731. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Zuurbier SM, Coutinho JM, Majoie CB, Coert BA, van den Munckhof P and Stam J: Decompressive hemicraniectomy in severe cerebral venous thrombosis: a prospective case series. J Neurol. 259:1099–1105. 2012. View Article : Google Scholar :

23 

Ferro JM, Crassard I, Coutinho JM, et al: Decompressive surgery in cerebrovenous thrombosis: a multicenter registry and a systematic review of individual patient data. Stroke. 42:2825–2831. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Zubkov AY, McBane RD, Brown RD and Rabinstein AA: Brain lesions in cerebral venous sinus thrombosis. Stroke. 40:1509–1511. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhen Y, Zhang N, He L, Shen L and Yan K: Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis. Exp Ther Med 9: 1080-1084, 2015.
APA
Zhen, Y., Zhang, N., He, L., Shen, L., & Yan, K. (2015). Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis. Experimental and Therapeutic Medicine, 9, 1080-1084. https://doi.org/10.3892/etm.2015.2198
MLA
Zhen, Y., Zhang, N., He, L., Shen, L., Yan, K."Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis". Experimental and Therapeutic Medicine 9.3 (2015): 1080-1084.
Chicago
Zhen, Y., Zhang, N., He, L., Shen, L., Yan, K."Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1080-1084. https://doi.org/10.3892/etm.2015.2198
Copy and paste a formatted citation
x
Spandidos Publications style
Zhen Y, Zhang N, He L, Shen L and Yan K: Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis. Exp Ther Med 9: 1080-1084, 2015.
APA
Zhen, Y., Zhang, N., He, L., Shen, L., & Yan, K. (2015). Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis. Experimental and Therapeutic Medicine, 9, 1080-1084. https://doi.org/10.3892/etm.2015.2198
MLA
Zhen, Y., Zhang, N., He, L., Shen, L., Yan, K."Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis". Experimental and Therapeutic Medicine 9.3 (2015): 1080-1084.
Chicago
Zhen, Y., Zhang, N., He, L., Shen, L., Yan, K."Mechanical thrombectomy combined with recombinant tissue plasminogen activator thrombolysis in the venous sinus for the treatment of severe cerebral venous sinus thrombosis". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1080-1084. https://doi.org/10.3892/etm.2015.2198
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