Biocompatibility and osteogenic properties of porous tantalum

Wang,Qian; Zhang,Hui; Li,Qijia; Ye,Lei; Gan,Hongquan; Liu,Yingjie; Wang,Hui; Wang,Zhiqiang

doi:10.3892/etm.2015.2208

Biocompatibility and osteogenic properties of porous tantalum

Authors:
- Qian Wang
- Hui Zhang
- Qijia Li
- Lei Ye
- Hongquan Gan
- Yingjie Liu
- Hui Wang
- Zhiqiang Wang
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Affiliations: Graduate School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Experimental Center, Hebei United University, Tangshan, Hebei 063000, P.R. China, Chongqing Runze Pharmaceutical Co. Ltd., Chongqing 401120, P.R. China, Department of Orthopedics, Affiliated Hospital of Hebei United University, Tangshan, Hebei 063000, P.R. China
Published online on: January 23, 2015 https://doi.org/10.3892/etm.2015.2208
Pages: 780-786
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum‑host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum‑host bone interface and pores. By week 12, the tantalum‑host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non‑toxic, biocompatible and a promising material for use in bone tissue engineering applications.

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