Role of quetiapine beyond its clinical efficacy in bipolar disorder: From neuroprotection to the treatment of psychiatric disorders (Review)

  • Authors:
    • Márcio G. Soeiro‑de‑Souza
    • Vasco Videira Dias
    • Giovanni Missio
    • Vicent Balanzá‑Martinez
    • Leandro Valiengo
    • André F. Carvalho
    • Ricardo Alberto Moreno
  • View Affiliations

  • Published online on: January 23, 2015     https://doi.org/10.3892/etm.2015.2213
  • Pages: 643-652
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Abstract

The aim of the present review was to discuss the following aspects of treatment with quetiapine in psychiatric disorders: i) Neurocognition and functional recovery in bipolar disorder (BD); ii) neuroprotective profile in different models; and iii) potential off‑label indications. A PubMed search was conducted of articles published in English between 2000 and 2012 on quetiapine, cross‑referenced with the terms ‘anxiety’, ‘attention deficit disorder’, ‘borderline personality disorder’, ‘dementia’, ‘insomnia’, ‘major depressive disorder’ (MDD), ‘obsessive‑compulsive disorder’, ‘post‑traumatic stress disorder’, ‘remission’, ‘cognition’, ‘neurobiology’, ‘neuroprotection’, ‘efficacy’ and ‘effectiveness’. Articles were selected from meta‑analyses, randomized clinical trials and open trials, and the results were summarized. Quetiapine, when studied in off‑label conditions, has shown efficacy as a monotherapy in MDD and general anxiety disorder. Quetiapine also appears to exhibit a small beneficial effect in dementia. The review of other conditions was affected by methodological limitations that precluded any definitive conclusions on the efficacy or safety of quetiapine. Overall, the present review shows evidence supporting a potential role for quetiapine in improving cognition, functional recovery and negative symptoms in a cost‑effective manner in BD. These benefits of quetiapine are potentially associated with its well‑described neuroprotective effects; however, further studies are clearly warranted.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Soeiro‑de‑Souza MG, Dias VV, Missio G, Balanzá‑Martinez V, Valiengo L, Carvalho AF and Moreno RA: Role of quetiapine beyond its clinical efficacy in bipolar disorder: From neuroprotection to the treatment of psychiatric disorders (Review). Exp Ther Med 9: 643-652, 2015.
APA
Soeiro‑de‑Souza, M.G., Dias, V.V., Missio, G., Balanzá‑Martinez, V., Valiengo, L., Carvalho, A.F., & Moreno, R.A. (2015). Role of quetiapine beyond its clinical efficacy in bipolar disorder: From neuroprotection to the treatment of psychiatric disorders (Review). Experimental and Therapeutic Medicine, 9, 643-652. https://doi.org/10.3892/etm.2015.2213
MLA
Soeiro‑de‑Souza, M. G., Dias, V. V., Missio, G., Balanzá‑Martinez, V., Valiengo, L., Carvalho, A. F., Moreno, R. A."Role of quetiapine beyond its clinical efficacy in bipolar disorder: From neuroprotection to the treatment of psychiatric disorders (Review)". Experimental and Therapeutic Medicine 9.3 (2015): 643-652.
Chicago
Soeiro‑de‑Souza, M. G., Dias, V. V., Missio, G., Balanzá‑Martinez, V., Valiengo, L., Carvalho, A. F., Moreno, R. A."Role of quetiapine beyond its clinical efficacy in bipolar disorder: From neuroprotection to the treatment of psychiatric disorders (Review)". Experimental and Therapeutic Medicine 9, no. 3 (2015): 643-652. https://doi.org/10.3892/etm.2015.2213