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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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March-2015 Volume 9 Issue 3

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International Journal of Molecular Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer

  • Authors:
    • Bin Chen
    • Lifen Liu
    • Haiyan Xu
    • Yijin Yang
    • Ling Zhang
    • Fengchun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu 215000, P.R. China, Department of Gynecology and Obstetrics, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China
  • Pages: 1063-1067
    |
    Published online on: January 26, 2015
       https://doi.org/10.3892/etm.2015.2217
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Abstract

The aim of this study was to compare the immune function of patients with cervical cancer and the cancer recurrence rate in patients treated with biological immune therapy combined with chemotherapy or with chemotherapy only. A total of 79 postoperative patients with cervical cancer participated in the present study. They were randomly divided into a control group and an experimental group. Patients in the control group were treated with cisplatin chemotherapy. Patients in the experimental group were treated with dendritic cell‑cytokine‑induced killer (DC‑CIK) cells combined with cisplatin chemotherapy. The CD3+, CD4+, CD8+, CD16+, CD56+ and CD4+CD25+ cell ratios in peripheral blood, and the expression levels of perforin, granzyme B (GraB) and CD107a of peripheral blood mononuclear cells (PBMCs) in all patients prior to and following treatment were observed. The changes of immune function and recurrence rate between these two groups prior to and following treatment were compared. Prior to treatment, the lymphocyte ratio had no significant difference between the two groups (P>0.05). Following treatment, the lymphocyte ratio in the experimental group was significantly higher than that in the control group (P<0.05). The positive expression levels of perforin, GraB and CD107a of PBMCs in the experimental group following treatment were significantly higher than those prior to treatment and those of the control group (P<0.05). The cumulative recurrence rate in the experimental group was significantly lower than that in the control group (P<0.05). In conclusion, in postoperative patients with cervical cancer, treatment with DC‑CIK cells combined with cisplatin chemotherapy significantly improved the immune function, reduced the recurrence rate and prolonged the survival time of the patients.
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1 

Bynum SA, Brandt HM, Sharpe PA, Williams MS and Kerr JC: Working to close the gap: identifying predictors of HPV vaccine uptake among young African American women. J Health Care Poor Underserved. 22:549–561. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Wang XC and Wu MY: Progress. on DC-CIK-based adoptive cellular immunotherapy for uterine cervical neoplasm. Guangdong Yao Xue Yuan Xue Bao. 29:575–579. 2013.(In Chinese).

3 

Tewari KS and Monk BJ: New strategies in advanced cervical cancer: from angiogenesis blockade to immunotherapy. Clin Cancer Res. 20:5349–5358. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Wang FS, Liu MX, Zhang B, et al: Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo. World J Gastroenterol. 8:464–468. 2002.PubMed/NCBI

5 

Itsumi M and Tatsugami K: Immunotherapy for renal cell carcinoma. Clin Dev Immunol. 2010:2845812010. View Article : Google Scholar

6 

Kim HM, Lim J, Kang JS, et al: Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model. Int Immunopharmacol. 9:375–380. 2009. View Article : Google Scholar

7 

Hontscha C, Borck Y, Zhou H, Messmer D and Schmidt-Wolf IG: Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC). J Cancer Res Clin Oncol. 137:305–310. 2011. View Article : Google Scholar

8 

Palucka K and Banchereau J: Cancer immunotherapy via dendritic cells. Nat Rev Cancer. 12:265–277. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Bhargava A, Bunkar N, Khare NK, Mishra D and Mishra PK: Nanoengineered strategies to optimize dendritic cells for gastrointestinal tumor immunotherapy: from biology to translational medicine. Nanomedicine (Lond). 9:2187–2202. 2014. View Article : Google Scholar

10 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Kastritis E, Bamias A, Bozas G, et al: The impact of age in the outcome of patients with advanced or recurrent cervical cancer after platinum-based chemotherapy. Gynecol Oncol. 104:372–376. 2007. View Article : Google Scholar

12 

Motz GT and Coukos G: Deciphering and reversing tumor immune suppression. Immunity. 39:61–73. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Lindau D, Gielen P, Kroesen M, Wesseling P and Adema GJ: The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology. 138:105–115. 2013. View Article : Google Scholar :

14 

Hasan UA, Bates E, Takeshita F, et al: TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16. J Immunol. 178:3186–3197. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Wang X, Yu W, Li H, Yu J, Zhang X, Ren X and Cao S: Can the dual-functional capability of CIK cells be used to improve antitumor effects? Cell Immunol. 287:18–22. 2014. View Article : Google Scholar

16 

Wang QJ, Wang H, Pan K, et al: Comparative study on anti-tumor immune response of autologous cytokine-induced killer (CIK) cells, dendritic cells-CIK (DC-CIK) and semi-allogeneic DC-CIK. Chin J Cancer. 29:641–648. 201

17 

Zheng YW, Li RM, Zhang XW and Ren XB: Current adoptive immunotherapy in non-small cell lung cancer and potential influence of therapy outcome. Cancer Invest. 31:197–205. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Ren J, Di L, Song G, Yu J, et al: Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences. Clin Transl Oncol. 15:780–788. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Yang HZ, Shi N, Li LN, Kang H and Yang LN: Clinical research of interventional treatment combined with CIK in patients with uterine cervix cancer. Haerbin Yi Ke Da Xue Xue Bao. 44:263–266. 2010.(In Chinese).

20 

Zhu YH, Liu JQ, Cao H, et al: Clinical efficiency of radiotherapy combined with self-immune cell therapy for cervical carcinoma. Zhongguo Zhong Liu Sheng Wu Zhi Liao Za Zhi. 19:421–427. 2012.(In Chinese).

21 

Laurin D, Marin V, Biagi E, et al: Exploration of the lysis mechanisms of leukaemic blasts by chimaeric T-cells. J Biomed Biotechnol. 2010:2345402010. View Article : Google Scholar : PubMed/NCBI

22 

Hackstein H and Thomson AW: Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol. 4:24–34. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Yang L, Ren B, Li H, Yu J, Cao S, Hao X and Ren X: Enhanced antitumor effects of DC-activated CIKs to chemotherapy treatment in a single cohort of advanced non-small-cell lung cancer patients. Cancer Immunol Immunother. 62:65–73. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Liu L, Xu H, Yang Y, Zhang L and Zhang F: Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer. Exp Ther Med 9: 1063-1067, 2015.
APA
Chen, B., Liu, L., Xu, H., Yang, Y., Zhang, L., & Zhang, F. (2015). Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer. Experimental and Therapeutic Medicine, 9, 1063-1067. https://doi.org/10.3892/etm.2015.2217
MLA
Chen, B., Liu, L., Xu, H., Yang, Y., Zhang, L., Zhang, F."Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer". Experimental and Therapeutic Medicine 9.3 (2015): 1063-1067.
Chicago
Chen, B., Liu, L., Xu, H., Yang, Y., Zhang, L., Zhang, F."Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1063-1067. https://doi.org/10.3892/etm.2015.2217
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Liu L, Xu H, Yang Y, Zhang L and Zhang F: Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer. Exp Ther Med 9: 1063-1067, 2015.
APA
Chen, B., Liu, L., Xu, H., Yang, Y., Zhang, L., & Zhang, F. (2015). Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer. Experimental and Therapeutic Medicine, 9, 1063-1067. https://doi.org/10.3892/etm.2015.2217
MLA
Chen, B., Liu, L., Xu, H., Yang, Y., Zhang, L., Zhang, F."Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer". Experimental and Therapeutic Medicine 9.3 (2015): 1063-1067.
Chicago
Chen, B., Liu, L., Xu, H., Yang, Y., Zhang, L., Zhang, F."Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1063-1067. https://doi.org/10.3892/etm.2015.2217
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