Effect of hydrogen sulfide on inflammatory cytokines in acute myocardial ischemia injury in rats

  • Authors:
    • Fang Liu
    • Guang‑Jie Liu
    • Na Liu
    • Gang Zhang
    • Jian‑Xin Zhang
    • Lan‑Fang Li
  • View Affiliations

  • Published online on: January 26, 2015     https://doi.org/10.3892/etm.2015.2218
  • Pages: 1068-1074
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Abstract

Hydrogen sulfide (H2S) is believed to be involved in numerous physiological and pathophysiological processes, and now it is recognized as the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide; however, the effects of H2S on inflammatory factors in acute myocardial ischemia injury in rats have not been clarified. In the present study, sodium hydrosulfide (NaHS) was used as the H2S donor. Thirty‑six male Sprague Dawley rats were randomly divided into five groups: Sham, ischemia, ischemia + low‑dose (0.78 mg/kg) NaHS, ischemia + medium‑dose (1.56 mg/kg) NaHS, ischemia + high‑dose (3.12 mg/kg) NaHS and ischemia + propargylglycine (PPG) (30 mg/kg). The rats in each group were sacrificed 6 h after the surgery for sample collection. Compared with the ischemia group, the cardiac damage in the rats in the ischemia + NaHS groups was significantly reduced, particularly in the high‑dose group; in the ischemia + PPG group, the myocardial injury was aggravated compared with that in the ischemia group. Compared with the ischemia group, the levels of interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α (TNF‑α) in the serum of rats in the ischemia + medium‑ and high‑dose NaHS groups were significantly reduced, and the expression of intercellular adhesion molecule‑1 (ICAM‑1) mRNA and nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) protein in the myocardial tissues of rats was significantly reduced. In the ischemia + PPG group, the TNF‑α, IL‑1β and IL‑6 levels in the serum were significantly increased, the expression of ICAM‑1 mRNA was increased, although without a significant difference, and the expression of NF‑κB was increased. The findings of the present study provide novel evidence for the dual effects of H2S on acute myocardial ischemia injury via the modulation of inflammatory factors.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu F, Liu GJ, Liu N, Zhang G, Zhang JX and Li LF: Effect of hydrogen sulfide on inflammatory cytokines in acute myocardial ischemia injury in rats. Exp Ther Med 9: 1068-1074, 2015
APA
Liu, F., Liu, G., Liu, N., Zhang, G., Zhang, J., & Li, L. (2015). Effect of hydrogen sulfide on inflammatory cytokines in acute myocardial ischemia injury in rats. Experimental and Therapeutic Medicine, 9, 1068-1074. https://doi.org/10.3892/etm.2015.2218
MLA
Liu, F., Liu, G., Liu, N., Zhang, G., Zhang, J., Li, L."Effect of hydrogen sulfide on inflammatory cytokines in acute myocardial ischemia injury in rats". Experimental and Therapeutic Medicine 9.3 (2015): 1068-1074.
Chicago
Liu, F., Liu, G., Liu, N., Zhang, G., Zhang, J., Li, L."Effect of hydrogen sulfide on inflammatory cytokines in acute myocardial ischemia injury in rats". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1068-1074. https://doi.org/10.3892/etm.2015.2218