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Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis

  • Authors:
    • Cong Feng
    • Xuan Su
    • Xuan Zhou
    • Li‑Li Wang
    • Bei Li
    • Li Chen
    • Fa‑Qin Lv
    • Tan‑Shi Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, General Hospital of the PLA, Beijing 100853, P.R. China, Department of Hepatology-Immunology, Beijing You An Hospital of the Capital Medical University, Beijing 100069, P.R. China, Department of Ultrasound, General Hospital of the PLA, Beijing 100853, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1171-1177
    |
    Published online on: February 3, 2015
       https://doi.org/10.3892/etm.2015.2251
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Abstract

The aim of this study was to investigate the effect of early peritoneal lavage with ulinastatin on the outcome of a rat model of severe acute pancreatitis (SAP). A total of 80 male Wistar rats were randomly divided into the following groups: Sham‑operated (C), SAP model (M), saline lavage (SL), intravenous ulinastatin (IU), early ulinastatin lavage (EUL) and late ulinastatin lavage (LUL). Intraperitoneal lavage or injection were performed immediately subsequent to the establishment of the SAP model in groups SL, IU and EUL and 3 h later in group LUL. Intraperitoneal lavage with or without ulinastatin was performed for 3 h. The survival time of the rats in groups C, M, EUL and LUL was recorded over a 12‑h period and the median survival time was calculated. At 3 h after the induction of SAP, histopathological analyses were performed and the biochemical parameters of groups C, M, SL, IU and EUL were assessed. Groups EUL and LUL exhibited an increased median survival time compared with Group M, with the survival time of the rats in group EUL markedly longer than that in the group LUL rats. Group SL, IU and EUL rats were found to have reduced plasma activities of amylase, lipase, aspartate transaminase and alanine transaminase, with the biggest change observed in the group EUL rats. Furthermore, the intervention in groups SL and EUL was more effective at reducing creatinine and urea levels than that in group IU. Rats in group EUL exhibited a greater inhibition of the SAP‑induced increase in troponin T levels than rats in groups SL and IU. The pathological severity scores of the pancreas, liver, kidney and lung in group EUL were significantly lower than those in groups M and better than those in groups SL and IU. In conclusion, early intraperitoneal lavage with ulinastatin significantly improves the median survival time and protects multi‑organ function in an SAP model.
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1 

Leonhardt U, Seidensticker F, Fussek M, Stöckmann F and Creutzfeldt W: Camostate (FOY-305) improves the therapeutic effect of peritoneal lavage on taurocholate induced pancreatitis. Gut. 31:934–937. 1990. View Article : Google Scholar : PubMed/NCBI

2 

Wilson C and Imrie CW: Effective intraperitoneal antiprotease therapy for taurocholate-induced pancreatitis in rats. Br J Surg. 77:1252–1255. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Fric P, Slabý J, Kasafírek E, Kocna P and Marek J: Effective peritoneal therapy of acute pancreatitis in the rat with glutaryl-trialanin-ethylamide: a novel inhibitor of pancreatic elastase. Gut. 33:701–706. 1992. View Article : Google Scholar : PubMed/NCBI

4 

Balldin G, Borgström A, Genell S and Ohlsson K: The effect of peritoneal lavage and aprotinin in the treatment of severe acute pancreatitis. Res Exp Med (Berl). 183:203–213. 1983. View Article : Google Scholar

5 

Berling R, Borgström A and Ohlsson K: Peritoneal lavage with aprotinin in patients with severe acute pancreatitis. Effects on plasma and peritoneal levels of trypsin and leukocyte proteases and their major inhibitors. Int J Pancreatol. 24:9–17. 1998.PubMed/NCBI

6 

Dong Z, Petrov MS, Xu J, Shanbhag S, Windsor JA and Pang S: Peritoneal lavage for severe acute pancreatitis: a systematic review of randomised trials. World J Surg. 34:2103–2108. 2010. View Article : Google Scholar : PubMed/NCBI

7 

McKay CJ, Evans S, Sinclair M, Carter CR and Imrie CW: High early mortality rate from acute pancreatitis in Scotland, 1984–1995. Br J Surg. 86:1302–1305. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Hirata K: Essential therapeutic strategies for acute pancreatitis - guidelines for initial treatment and their significance. Nihon Rinsho. 62:2049–2056. 2004.(In Japanese). PubMed/NCBI

9 

Botoi G and Andercou A: Early and prolonged peritoneal lavage with laparoscopy in severe acute pancreatitis. Chirurgia (Bucur). 104:49–53. 2009.(In Romanian).

10 

Inoue K, Takano H, Shimada A, et al: Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide. Mol Pharmacol. 67:673–680. 2005. View Article : Google Scholar

11 

Ohnishi H, Kosuzume H, Ashida Y, Kato K and Honjo I: Effects of urinary trypsin inhibitor on pancreatic enzymes and experimental acute pancreatitis. Dig Dis Sci. 29:26–32. 1984. View Article : Google Scholar : PubMed/NCBI

12 

Zhang XP, Zhang L, Wang Y, et al: Study of the protective effects of dexamethasone on multiple organ injury in rats with severe acute pancreatitis. JOP. 8:400–412. 2007.PubMed/NCBI

13 

Zhang XP, Tian H, Lu B, et al: Tissue microarrays in pathological examination of apoptotic acinar cells induced by dexamethasone in the pancreas of rats with severe acute pancreatitis. Hepatobiliary Pancreat Dis Int. 6:527–536. 2007.PubMed/NCBI

14 

Zhang XP, Tian H, Lai YH, et al: Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol. 13:5079–5089. 2007.PubMed/NCBI

15 

Niederau C, Crass RA, Silver G, Ferrell LD and Grendell JH: Therapeutic regimens in acute experimental hemorrhagic pancreatitis. Effects of hydration, oxygenation, peritoneal lavage and a potent protease inhibitor. Gastroenterology. 95:1648–1657. 1988.PubMed/NCBI

16 

Platell C, Cooper D and Hall JC: A meta-analysis of peritoneal lavage for acute pancreatitis. J Gastroenterol Hepatol. 16:689–693. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Takeyama Y: Indications for and efficiency of peritoneal lavage in severe acute pancreatitis. Nihon Rinsho. 62:2087–2093. 2004.(In Japanese). PubMed/NCBI

18 

Keck T, Balcom JH, Antoniu BA, Lewandrowski K, Warshaw AL and Fernández-del Castillo CF: Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis. Surgery. 130:175–181. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Matsukawa H, Hara A, Ito T, et al: Continuous arterial infusion of protease inhibitor with supplementary therapy for the patients with severe acute pancreatitis - clinical effect of arterial injection of ulinastatin. Nihon Shokakibyo Gakkai Zasshi. 95:1229–1234. 1998.(In Japanese). PubMed/NCBI

20 

Warndorf MG, Kurtzman JT, Bartel MJ, et al: Early fluid resuscitation reduces morbidity among patients with acute pancreatitis. Clin Gastroenterol Hepatol. 9:705–709. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Schröder T: The effect of early pancreatectomy and peritoneal lavage on the development of experimental haemorrhagic pancreatitis in pigs. Scand J Gastroenterol. 17:167–171. 1982. View Article : Google Scholar : PubMed/NCBI

22 

Trepte CJ, Bachmann KA, Stork JH, et al: The impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis. Intensive Care Med. 39:717–726. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Kuwabara K, Matsuda S, Fushimi K, Ishikawa KB, Horiguchi H and Fujimori K: Early crystalloid fluid volume management in acute pancreatitis: association with mortality and organ failure. Pancreatology. 11:351–361. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Feng C, Su X, Zhou X, Wang LL, Li B, Chen L, Lv FQ and Li TS: Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis. Exp Ther Med 9: 1171-1177, 2015.
APA
Feng, C., Su, X., Zhou, X., Wang, L., Li, B., Chen, L. ... Li, T. (2015). Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis. Experimental and Therapeutic Medicine, 9, 1171-1177. https://doi.org/10.3892/etm.2015.2251
MLA
Feng, C., Su, X., Zhou, X., Wang, L., Li, B., Chen, L., Lv, F., Li, T."Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis". Experimental and Therapeutic Medicine 9.4 (2015): 1171-1177.
Chicago
Feng, C., Su, X., Zhou, X., Wang, L., Li, B., Chen, L., Lv, F., Li, T."Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1171-1177. https://doi.org/10.3892/etm.2015.2251
Copy and paste a formatted citation
x
Spandidos Publications style
Feng C, Su X, Zhou X, Wang LL, Li B, Chen L, Lv FQ and Li TS: Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis. Exp Ther Med 9: 1171-1177, 2015.
APA
Feng, C., Su, X., Zhou, X., Wang, L., Li, B., Chen, L. ... Li, T. (2015). Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis. Experimental and Therapeutic Medicine, 9, 1171-1177. https://doi.org/10.3892/etm.2015.2251
MLA
Feng, C., Su, X., Zhou, X., Wang, L., Li, B., Chen, L., Lv, F., Li, T."Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis". Experimental and Therapeutic Medicine 9.4 (2015): 1171-1177.
Chicago
Feng, C., Su, X., Zhou, X., Wang, L., Li, B., Chen, L., Lv, F., Li, T."Early peritoneal lavage with ulinastatin improves outcome and enhances multi-organ protection in a model of severe acute pancreatitis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1171-1177. https://doi.org/10.3892/etm.2015.2251
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