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Article

Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold

  • Authors:
    • Anke Sun
    • Qingyan Meng
    • Wantong Li
    • Songbo Liu
    • Wei Chen
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110016, P.R. China, Department of Burns and Aesthetic Medicine, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110016, P.R. China, Department of Microsurgery, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110016, P.R. China, Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenyang, Liaoning 110016, P.R. China
  • Pages: 1482-1488
    |
    Published online on: February 5, 2015
       https://doi.org/10.3892/etm.2015.2262
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Abstract

The aim of the present study was to construct tissue‑engineered laryngeal cartilage with a hollow, semi‑flared shape using a poly(3‑hydroxybutyrate‑co‑3‑hydroxyhexanoate) (PHBHH) scaffold. Porous PHBHH was prepared and formed into a hollow, semi‑flared shape, and the cell‑material composites were cultured for one week in vitro prior to implantation in vivo. Cells of the nine rabbits of the experimental group were filled and encapsulated in the myofascial flap‑shaping material composite for in situ implantation. The three rabbits in the control group were treated with the shaping material without the chondrocytes. Cartilage regeneration was assessed at six, 12 and 18 weeks after surgery. In the experimental group, the shape and porosity of the material were ideal, the cells exhibited good adhesion with the material and the myofascial flap blood supply was rich. The engineered laryngeal cartilage with the hollow, semi‑flared shape was ideally formed, and the cartilage formed at six weeks after the surgery. Further maturation of the cartilage was observed at 12 and 18 weeks after the surgery. PHBHH was a suitable material for the formation of a hollow, semi‑flared shape with good cellular compatibility. Myofascial flap filling and wrapping can be used to build tissue‑engineered laryngeal cartilage with a hollow, semi‑flared shape.
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Copy and paste a formatted citation
Spandidos Publications style
Sun A, Meng Q, Li W, Liu S and Chen W: Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold. Exp Ther Med 9: 1482-1488, 2015.
APA
Sun, A., Meng, Q., Li, W., Liu, S., & Chen, W. (2015). Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold. Experimental and Therapeutic Medicine, 9, 1482-1488. https://doi.org/10.3892/etm.2015.2262
MLA
Sun, A., Meng, Q., Li, W., Liu, S., Chen, W."Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold". Experimental and Therapeutic Medicine 9.4 (2015): 1482-1488.
Chicago
Sun, A., Meng, Q., Li, W., Liu, S., Chen, W."Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1482-1488. https://doi.org/10.3892/etm.2015.2262
Copy and paste a formatted citation
x
Spandidos Publications style
Sun A, Meng Q, Li W, Liu S and Chen W: Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold. Exp Ther Med 9: 1482-1488, 2015.
APA
Sun, A., Meng, Q., Li, W., Liu, S., & Chen, W. (2015). Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold. Experimental and Therapeutic Medicine, 9, 1482-1488. https://doi.org/10.3892/etm.2015.2262
MLA
Sun, A., Meng, Q., Li, W., Liu, S., Chen, W."Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold". Experimental and Therapeutic Medicine 9.4 (2015): 1482-1488.
Chicago
Sun, A., Meng, Q., Li, W., Liu, S., Chen, W."Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1482-1488. https://doi.org/10.3892/etm.2015.2262
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