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VE/VCO2 slope and its prognostic value in patients with chronic heart failure

  • Authors:
    • Yuqin Shen
    • Xiaoyu Zhang
    • Wenlin Ma
    • Haoming Song
    • Zhu Gong
    • Qiang Wang
    • Lin Che
    • Wenjun Xu
    • Jinfa Jiang
    • Jiahong Xu
    • Wenwen Yan
    • Lin Zhou
    • Yi Ni
    • Guanghe Li
    • Qiping Zhang
    • Lemin Wang

  • View Affiliations

  • Published online on: February 5, 2015     https://doi.org/10.3892/etm.2015.2267
  • Pages: 1407-1412
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Abstract

The minute ventilation/carbon dioxide production (VE/VCO2) slope has been widely demonstrated to have strong prognostic value in patients with chronic heart failure (CHF), and the risk of mortality is believed to increase when the VE/VCO2 slope is >32.8; however, there is little evidence concerning the prognostic value of the VE/VCO2 slope in Chinese patients. In the present study, the prognostic value of the VE/VCO2 slope was investigated in patients with CHF. A total of 258 subjects underwent symptom‑limited cardiopulmonary exercise testing (CPET) and were divided into CHF (113 males and 16 females; LVEF <0.49) and control (106 males and 23 females) groups. The cardiac‑related events over a median 33.7‑month follow‑up period subsequent to the CPET were evaluated using receiver operating characteristic curve analysis. The VE/VCO2 slope was significantly different between the CHF and control groups (Ρ<0.001). The area under the curve (AUC) for the VE/VCO2 slope in predicting cardiac‑related mortalities in the patients with CHF was 0.670 (Ρ<0.05), and the sensitivity and specificity of the VE/VCO2 slope were 0.667 and 0.620, respectively. The optimal threshold of the VE/VCO2 slope for predicting cardiac‑related mortalities in patients with CHF was ≥39.3. The AUC for the VE/VCO2 slope in predicting cardiac‑related hospitalizations in patients with CHF was 0.682 (Ρ<0.05), and the sensitivity and specificity of the VE/VCO2 slope were 0.631 and 0.778, respectively. The optimal threshold of the VE/VCO2 slope for predicting cardiac‑related hospitalizations in patients with CHF was ≥32.9. In conclusion, ventilatory efficiency decreases in patients with CHF. The VE/VCO2 slope is a strong predictor of cardiac‑related mortalities in the patients with CHF analyzed.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shen Y, Zhang X, Ma W, Song H, Gong Z, Wang Q, Che L, Xu W, Jiang J, Xu J, Xu J, et al: VE/VCO2 slope and its prognostic value in patients with chronic heart failure. Exp Ther Med 9: 1407-1412, 2015
APA
Shen, Y., Zhang, X., Ma, W., Song, H., Gong, Z., Wang, Q. ... Wang, L. (2015). VE/VCO2 slope and its prognostic value in patients with chronic heart failure. Experimental and Therapeutic Medicine, 9, 1407-1412. https://doi.org/10.3892/etm.2015.2267
MLA
Shen, Y., Zhang, X., Ma, W., Song, H., Gong, Z., Wang, Q., Che, L., Xu, W., Jiang, J., Xu, J., Yan, W., Zhou, L., Ni, Y., Li, G., Zhang, Q., Wang, L."VE/VCO2 slope and its prognostic value in patients with chronic heart failure". Experimental and Therapeutic Medicine 9.4 (2015): 1407-1412.
Chicago
Shen, Y., Zhang, X., Ma, W., Song, H., Gong, Z., Wang, Q., Che, L., Xu, W., Jiang, J., Xu, J., Yan, W., Zhou, L., Ni, Y., Li, G., Zhang, Q., Wang, L."VE/VCO2 slope and its prognostic value in patients with chronic heart failure". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1407-1412. https://doi.org/10.3892/etm.2015.2267