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Article

Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state

  • Authors:
    • Mei Xue
    • Mei‑Lin Liu
    • Xin‑Yuan Zhu
    • Da‑Zhuo Shi
    • Hui‑Jun Yin
  • View Affiliations / Copyright

    Affiliations: Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Haidian, Beijing 100091, P.R. China, Department of Geriatric Medicine, Peking University First Hospital, Beijing 100034, P.R. China
  • Pages: 1477-1481
    |
    Published online on: February 6, 2015
       https://doi.org/10.3892/etm.2015.2271
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Abstract

The aim of the present study was to investigate the effects of extract of Panax quinquefolius and Corydalis tuber (EPC) on platelet activation and the hypercoagulable state in rats with acute myocardial infarction (AMI). The MI model in Wistar rats was induced by coronary artery ligation. Sham surgery was performed as a control. The surviving rats that underwent MI surgery were divided into control (administered normal saline), metoprolol (9 mg/kg) and low‑, moderate‑ and high‑dose EPC groups (0.54, 1.08 g/kg and 2.16 g/kg, respectively). Saline, metoprolol and EPC were administered by gastrogavage for two consecutive weeks. The morphological changes of the myocardium were assessed by hematoxylin and eosin and nitroblue tetrazolium staining. Serum von Willebrand factor (vWF), D‑dimer (DD), platelet membrane glycoproteins IIb‑IIIa (GPIIb‑IIIa) and CD62P levels were assessed using enzyme‑linked immunosorbent assay. EPC attenuated the pathological changes of the myocardium. High‑dose EPC decreased the serum concentration of vWF when compared with control group. Moderate and high doses of EPC decreased the DD and GPIIb‑IIIa levels, and the CD62P level was gradually decreased with EPC dose escalation. The results therefore demonstrated that EPC protects the myocardium by inhibiting platelet activation and improving the hypercoagulable state in a rat model of AMI.
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Copy and paste a formatted citation
Spandidos Publications style
Xue M, Liu ML, Zhu XY, Shi DZ and Yin HJ: Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state. Exp Ther Med 9: 1477-1481, 2015.
APA
Xue, M., Liu, M., Zhu, X., Shi, D., & Yin, H. (2015). Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state. Experimental and Therapeutic Medicine, 9, 1477-1481. https://doi.org/10.3892/etm.2015.2271
MLA
Xue, M., Liu, M., Zhu, X., Shi, D., Yin, H."Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state". Experimental and Therapeutic Medicine 9.4 (2015): 1477-1481.
Chicago
Xue, M., Liu, M., Zhu, X., Shi, D., Yin, H."Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1477-1481. https://doi.org/10.3892/etm.2015.2271
Copy and paste a formatted citation
x
Spandidos Publications style
Xue M, Liu ML, Zhu XY, Shi DZ and Yin HJ: Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state. Exp Ther Med 9: 1477-1481, 2015.
APA
Xue, M., Liu, M., Zhu, X., Shi, D., & Yin, H. (2015). Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state. Experimental and Therapeutic Medicine, 9, 1477-1481. https://doi.org/10.3892/etm.2015.2271
MLA
Xue, M., Liu, M., Zhu, X., Shi, D., Yin, H."Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state". Experimental and Therapeutic Medicine 9.4 (2015): 1477-1481.
Chicago
Xue, M., Liu, M., Zhu, X., Shi, D., Yin, H."Effective components of Panax quinquefolius and Corydalis tuber protect the myocardium by inhibiting platelet activation and improving the hypercoagulable state". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1477-1481. https://doi.org/10.3892/etm.2015.2271
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