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Article

Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis

  • Authors:
    • Liqiong Hou
    • Tieyun Zhao
    • Yunhui Liu
    • Yiyi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, P.R. China
  • Pages: 1528-1536
    |
    Published online on: February 9, 2015
       https://doi.org/10.3892/etm.2015.2277
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Abstract

Previous randomized controlled trials (RCTs) have reported conflicting results for the efficacy of sitagliptin and sulfonylurea therapy in patients with type 2 diabetes mellitus showing inadequate glycemic control with metformin monotherapy. To clarify these findings, a meta‑analysis was conducted of the outcomes of all published RCTs comparing sitagliptin with sulfonylureas in the treatment of type 2 diabetes mellitus. Standard medical databases were searched to identify relevant English‑ and Chinese‑language RCTs. RCT results were compared regarding the mean change in glycated hemoglobin (HbA1c) level; the proportion achieving <7% HbAlc; and a change in body weight. No significant differences were found between the metformin plus sitagliptin and metformin plus sulfonylurea groups regarding HbAlc or the proportion achieving <7% HbAlc, while the metformin plus sitagliptin group experienced fewer hypoglycemic events (P<0.00001) and a greater reduction in body weight (P<0.00001). Metformin plus sitagliptin therapy may decrease HbAlc values in patients with type 2 diabetes mellitus who are not achieving their glycemic targets with metformin monotherapy in a manner similar to metformin plus sulfonylurea therapy, whilst posing a lower risk of hypoglycemia, and yielding a more beneficial effect on body weight.
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Copy and paste a formatted citation
Spandidos Publications style
Hou L, Zhao T, Liu Y and Zhang Y: Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis. Exp Ther Med 9: 1528-1536, 2015.
APA
Hou, L., Zhao, T., Liu, Y., & Zhang, Y. (2015). Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis. Experimental and Therapeutic Medicine, 9, 1528-1536. https://doi.org/10.3892/etm.2015.2277
MLA
Hou, L., Zhao, T., Liu, Y., Zhang, Y."Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis". Experimental and Therapeutic Medicine 9.4 (2015): 1528-1536.
Chicago
Hou, L., Zhao, T., Liu, Y., Zhang, Y."Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1528-1536. https://doi.org/10.3892/etm.2015.2277
Copy and paste a formatted citation
x
Spandidos Publications style
Hou L, Zhao T, Liu Y and Zhang Y: Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis. Exp Ther Med 9: 1528-1536, 2015.
APA
Hou, L., Zhao, T., Liu, Y., & Zhang, Y. (2015). Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis. Experimental and Therapeutic Medicine, 9, 1528-1536. https://doi.org/10.3892/etm.2015.2277
MLA
Hou, L., Zhao, T., Liu, Y., Zhang, Y."Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis". Experimental and Therapeutic Medicine 9.4 (2015): 1528-1536.
Chicago
Hou, L., Zhao, T., Liu, Y., Zhang, Y."Efficacy and safety of sitagliptin compared with sulfonylurea therapy in patients with type 2 diabetes showing inadequately controlled glycosylated hemoglobin with metformin monotherapy: A meta-analysis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1528-1536. https://doi.org/10.3892/etm.2015.2277
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