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April-2015 Volume 9 Issue 4

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Article

Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique

  • Authors:
    • Tian Tang
    • Duan-Lian Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 1331-1335
    |
    Published online on: February 12, 2015
       https://doi.org/10.3892/etm.2015.2287
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Abstract

The aim of the present study was to investigate the association of extracellular matrix metalloproteinase inducer (EMMPRIN) and human epidermal growth factor receptor (HER)‑2 protein expression in papillary thyroid carcinoma with lymph node metastasis (LNM), as well as the correlation between the two types of protein expression. A quantum dot‑based immunofluorescence technique was used to detect EMMPRIN and HER‑2 protein expression in 75 papillary thyroid carcinoma cases (including 70 cases of papillary thyroid carcinoma tissues and 5 cases of peri‑tumor tissues). The positive rate and expression of EMMPRIN and HER‑2 were compared and observed. The positive rate of EMMPRIN was 75.71% in papillary thyroid carcinoma tissues and 20.00% in peri‑tumor tissues (P<0.05). The positive rate of HER‑2 was 45.71% in papillary thyroid carcinoma tissues and 0% in peri‑tumor tissues (P>0.05). The expression of EMMPRIN and HER‑2 in papillary thyroid carcinoma was significantly associated with LNM (P<0.05). In addition, in the 70 papillary thyroid carcinoma tissues, the expression of EMMPRIN and HER‑2 was positively and significantly correlated. In conclusion, this study demonstrates that the co‑evolution of EMMPRIN and HER‑2 may promote the occurrence and development of papillary thyroid carcinoma and LNM.
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Copy and paste a formatted citation
Spandidos Publications style
Tang T and Zhang D: Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique. Exp Ther Med 9: 1331-1335, 2015.
APA
Tang, T., & Zhang, D. (2015). Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique. Experimental and Therapeutic Medicine, 9, 1331-1335. https://doi.org/10.3892/etm.2015.2287
MLA
Tang, T., Zhang, D."Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique". Experimental and Therapeutic Medicine 9.4 (2015): 1331-1335.
Chicago
Tang, T., Zhang, D."Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1331-1335. https://doi.org/10.3892/etm.2015.2287
Copy and paste a formatted citation
x
Spandidos Publications style
Tang T and Zhang D: Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique. Exp Ther Med 9: 1331-1335, 2015.
APA
Tang, T., & Zhang, D. (2015). Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique. Experimental and Therapeutic Medicine, 9, 1331-1335. https://doi.org/10.3892/etm.2015.2287
MLA
Tang, T., Zhang, D."Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique". Experimental and Therapeutic Medicine 9.4 (2015): 1331-1335.
Chicago
Tang, T., Zhang, D."Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1331-1335. https://doi.org/10.3892/etm.2015.2287
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