Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up

  • Authors:
    • Qi Wang
    • Yu Zhou
    • Tong Qiao
    • Min Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Drum Tower Clinical Medical College of Nanjing Medical University, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1545-1556
    |
    Published online on: February 13, 2015
       https://doi.org/10.3892/etm.2015.2293
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Several types of biodegradable polymer drug‑eluting stents (BPDES) have been used for percutaneous transluminal angioplasty; however, the safety and efficiency of these BPDES have not been fully evaluated. A meta‑analysis was, therefore, conducted to compare the clinical performance of BPDES with that of permanent polymer drug‑eluting stents (PPDES) in unselected patients with coronary stenosis. PubMed, Web of Science, Medline and The Cochrane Library were searched for randomized clinical trials (RCTs) from January 2005 to January 2014. Trials that compared BPDES with PPDES in patients with coronary stenosis were considered. Twelve RCTs with a total of 15,938 patients with coronary stenosis were included in this meta‑analysis. No significant difference was found between the two arms in the incidence of major adverse cardiac events (MACE) and definite or probable stent thrombosis (DpST) at the one‑year follow‑up (P>0.10). The use of BPDES, however, showed a tendency towards a lower risk of MACE (P=0.09) and a beneficial effect by reducing DpST episodes (P=0.04) at long‑term follow‑up, particularly when compared with the incidence of DpST at the one‑year follow‑up. BPDES also tended to be associated with a decreased late lumen loss in patients with coronary stenosis [instrumental variable =‑0.04; 95% confidence interval =‑0.08‑0.00; P=0.05). In conclusion, the one‑year outcomes following drug‑eluting stent implantation showed BPDES were noninferior to PPDES in unselected patients with coronary stenosis. Long‑term clinical outcomes, however, indicated that BPDES appeared to a present a lower risk of MACE and DpST.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Fischman DL, Leon MB, Baim DS, et al; Stent Restenosis Study Investigators. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med. 331:496–501. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Palmerini T, Biondi-Zoccai G, Della Riva D, et al: Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis. Lancet. 379:1393–1402. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Liistro F and Colombo A: Late acute thrombosis after paclitaxel eluting stent implantation. Heart. 86:262–264. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Brodie B, Pokharel Y, Fleishman N, Bensimhon A, Kissling G, et al: Very late stent thrombosis after primary percutaneous coronary intervention with bare-metal and drug-eluting stents for ST-segment elevation myocardial infarction: A 15-year single-center experience. JACC Cardiovasc Interv. 4:30–38. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Vorpahl M, Finn AV, Nakano M and Virmani R: The bioabsorption process: tissue and cellular mechanisms and outcomes. EuroIntervention. 5(Suppl F): F28–F35. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Wilson GJ, Nakazawa G, Schwartz RS, Huibregtse B, Poff B, et al: Comparison of inflammatory response after implantation of sirolimus- and paclitaxel-eluting stents in porcine coronary arteries. Circulation. 120:141–149. 1–2. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Byrne RA, Joner M and Kastrati A: Polymer coatings and delayed arterial healing following drug-eluting stent implantation. Minerva Cardioangiol. 57:567–584. 2009.PubMed/NCBI

8 

Lupi A, Rognoni A, Secco GG, Lazzero M, Nardi F, et al: Biodegradable versus durable polymer drug eluting stents in coronary artery disease: Insights from a meta-analysis of 5834 patients. Eur J Prev Cardiol. 21:411–424. 2014. View Article : Google Scholar

9 

Ahmed TA, Bergheanu SC, Stijnen T, Plevier JW, Quax PH and Jukema JW: Clinical performance of drug-eluting stents with biodegradable polymeric coating: A meta-analysis and systematic review. EuroIntervention. 7:505–516. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Higgins JPT and Green S: Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration; 2009

11 

Byrne RA, Kastrati A, Kufner S, Massberg S, Birkmeier KA, et al; Intracoronary Stenting and Angiographic Results. Test Efficacy of 3 Limus-Eluting Stents (ISAR-TEST-4) Trial Investigators: Randomized, non-inferiority trial of three limus agent-eluting stents with different polymer coatings: the Intracoronary Stenting and Angiographic Results: Test Efficacy of 3 Limus-Eluting Stents (ISAR-TEST-4) Trial. Eur Heart J. 30:2441–2449. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Byrne RA, Kastrati A, Massberg S, Wieczorek A, Laugwitz KL, et al; ISAR-TEST-4 Investigators. Biodegradable polymer versus permanent polymer drug-eluting stents and everolimus- versus sirolimus-eluting stents in patients with coronary artery disease: 3-year outcomes from a randomized clinical trial. J Am Coll Cardiol. 58:1325–1331. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Byrne RA, Kufner S, Tiroch K, Massberg S, Laugwitz KL, et al; ISAR-TEST-3 Investigators. Randomised trial of three rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis: 2-year follow-up results. Heart. 95:1489–1494. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Chevalier B, Serruys PW, Silber S, Garcia E, Suryapranata H, et al: Randomised comparison of Nobori, biolimus A9-eluting coronary stent with a Taxus(R), paclitaxel-eluting coronary stent in patients with stenosis in native coronary arteries: The Nobori 1 trial. EuroIntervention. 2:426–434. 2007.PubMed/NCBI

15 

Chevalier B, Silber S, Park SJ, Garcia E, Schuler G, et al: Randomized comparison of the Nobori Biolimus A9-eluting coronary stent with the Taxus Liberté paclitaxel-eluting coronary stent in patients with stenosis in native coronary arteries: the NOBORI 1 trial-Phase 2. Circ Cardiovasc Interv. 2:188–195. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Christiansen EH, Jensen LO, Thayssen P, Tilsted HH, Krusell LR, et al; Scandinavian Organization for Randomized Trials with Clinical Outcome (SORT OUT) V Investigators. Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): A randomised non-inferiority trial. Lancet. 381:661–669. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Gao RL, Xu B, Lansky AJ, Yang YJ, Ma CS, et al; TARGET I Investigators. A randomised comparison of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: Clinical and angiographic follow-up of the TARGET I trial. EuroIntervention. 9:75–83. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Kadota K, Muramatsu T, Iwabuchi M, Saito S, Hayashi Y, et al: Randomized comparison of the Nobori biolimus A9-eluting stent with the sirolimus-eluting stent in patients with stenosis in native coronary arteries. Catheter Cardiovasc Interv. 80:789–796. 2012. View Article : Google Scholar

19 

Krucoff MW, Kereiakes DJ, Petersen JL, et al; COSTAR II Investigators Group. A novel bioresorbable polymer paclitaxel-eluting stent for the treatment of single and multivessel coronary disease: Primary results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II study. J Am Coll Cardiol. 51:1543–1552. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Kufner S, Massberg S, Dommasch M, Byrne RA, Tiroch K, et al; Intracoronary Stenting and Angiographic Results. Test Efficacy of 3 Limus-Eluting Stents Trial Investigators: Angiographic outcomes with biodegradable polymer and permanent polymer drug-eluting stents. Catheter Cardiovasc Interv. 78:161–166. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Mehilli J, Byrne RA, Wieczorek A, Iijima R, Schulz S, et al; Intracoronary Stenting and Angiographic Restenosis Investigators-Test Efficacy of Rapamycin-Eluting Stents with Different Polymer Coating Strategies (ISAR-TEST-3). Randomized trial of three rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis. Eur Heart J. 29:1975–1982. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Natsuaki M, Kozuma K, Morimoto T, Kadota K, Muramatsu T, et al; NEXT Investigators. Biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent: a randomized, controlled, noninferiority trial. J Am Coll Cardiol. 62:181–190. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Serruys PW, Farooq V, Kalesan B, de Vries T, Buszman P, et al: Improved safety and reduction in stent thrombosis associated with biodegradable polymer-based biolimus-eluting stents versus durable polymer-based sirolimus-eluting stents in patients with coronary artery disease: Final 5-year report of the LEADERS (Limus Eluted From A Durable Versus ERodable Stent Coating) randomized, noninferiority trial. JACC Cardiovasc Interv. 6:777–789. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Smits PC, Hofma S, Togni M, Vázquez N, Valdés M, et al: Abluminal biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent (COMPARE II): A randomised, controlled, non-inferiority trial. Lancet. 381:651–660. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Windecker S, Serruys PW, Wandel S, Buszman P, Trznadel S, et al: Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer for coronary revascularisation (LEADERS): A randomised non-inferiority trial. Lancet. 372:1163–1173. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Zhang Y, Shen J, Li Z, Zhu A, Yuan Y, et al: Two-year clinical outcomes of different drug-eluting stents with different polymer coating strategies in coronary artery heart disease: A multi-centre, randomised, controlled clinical trial. Int J Cardiol. 168:2646–2652. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, et al; SIRIUS Investigators. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 349:1315–1323. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Stone GW, Ellis SG, Cannon L, Mann JT, Greenberg JD, et al; TAXUS V Investigators. Comparison of a polymer-based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: a randomized controlled trial. JAMA. 294:1215–1223. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Nakazawa G, Finn AV, Vorpahl M, Ladich ER, Kolodgie FD and Virmani R: Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents. J Am Coll Cardiol. 57:390–398. 2011. View Article : Google Scholar : PubMed/NCBI

30 

de Waha A, Stefanini GG, King LA, Byrne RA, Serruys PW, et al: Long-term outcomes of biodegradable polymer versus durable polymer drug-eluting stents in patients with diabetes a pooled analysis of individual patient data from 3 randomized trials. Int J Cardiol. 168:5162–5166. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Zhou Y, Qiao T and Zhou M: Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up. Exp Ther Med 9: 1545-1556, 2015.
APA
Wang, Q., Zhou, Y., Qiao, T., & Zhou, M. (2015). Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up. Experimental and Therapeutic Medicine, 9, 1545-1556. https://doi.org/10.3892/etm.2015.2293
MLA
Wang, Q., Zhou, Y., Qiao, T., Zhou, M."Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up". Experimental and Therapeutic Medicine 9.4 (2015): 1545-1556.
Chicago
Wang, Q., Zhou, Y., Qiao, T., Zhou, M."Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1545-1556. https://doi.org/10.3892/etm.2015.2293
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Zhou Y, Qiao T and Zhou M: Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up. Exp Ther Med 9: 1545-1556, 2015.
APA
Wang, Q., Zhou, Y., Qiao, T., & Zhou, M. (2015). Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up. Experimental and Therapeutic Medicine, 9, 1545-1556. https://doi.org/10.3892/etm.2015.2293
MLA
Wang, Q., Zhou, Y., Qiao, T., Zhou, M."Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up". Experimental and Therapeutic Medicine 9.4 (2015): 1545-1556.
Chicago
Wang, Q., Zhou, Y., Qiao, T., Zhou, M."Clinical performance of biodegradable versus permanent polymer drug‑eluting stents: A meta‑analysis of randomized clinical trials at long‑term follow‑up". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1545-1556. https://doi.org/10.3892/etm.2015.2293
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team