Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2015 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2015 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis

  • Authors:
    • Lei Zhang
    • Hui Liang
    • Hui Guan
    • Hualin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Qingdao Women and Children's Hospital, Qingdao, Shandong 266034, P.R. China
  • Pages: 1733-1738
    |
    Published online on: February 17, 2015
       https://doi.org/10.3892/etm.2015.2295
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the immune function of children with juvenile idiopathic arthritis (JIA). Flow cytometry and three-color direct immunofluorescence were used to examine cluster of differentiation (CD)3+ T‑lymphocyte subsets and CD28/cytotoxic T‑lymphocyte‑associated protein 4 (CTLA-4) expression in whole blood (using the no-wash method) from 36 children with JIA and 39 healthy children. During the active phase of JIA, CD28 expression on CD4+ T cells in children with JIA was significantly reduced; thus, CD4+CD28- T‑cell frequency increased, suggesting that CD4+ T‑cell and CD4+CD28- T‑cell apoptosis was inhibited in patients with JIA. The continued survival of these immune-active T lymphocytes may promote the occurrence and development of JIA. CTLA-4 expression levels on CD4+ and CD8+ T cells in children with JIA during the active phase were significantly higher than those in normal controls. As the majority of CD4+ T cells in patients with JIA are CD28-, they cannot be inactivated by the interaction between CTLA-4 and B7, leading to continuously high levels of CTLA-4 expression on the surface of CD4+ T cells without functional effect. Hence, T lymphocytes are continuously kept in a highly activated state that is difficult to stop. During the resting phase, the CD4+ and CD8+ T‑cell counts in children with JIA were similar to normal, and CD28 expression was also normal. This suggests that the frequency of CD4+CD28- T cells can be used as an indicator of the active phase of JIA. CTLA-4 expression on the surface of T cells in children with JIA during the resting phase was also similar to that in normal controls, suggesting that abnormal lymphocyte activation plays an important role in the active phase of JIA.
View Figures

Figure 1

Figure 2

View References

1 

Ravelli A and Martini A: Juvenile idiopathic arthritis. Lancet. 369:767–778. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Thierry S, Fautrel B, Lemelle I and Guillemin F: Prevalence and incidence of juvenile idiopathic arthritis: a systematic review. Joint Bone Spine. 81:112–117. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tugal-Tutkun I, Quartier P and Bodaghi B: Disease of the year: juvenile idiopathic arthritis-associated uveitis – classification and diagnostic approach. Ocul Immunol Inflamm. 22:56–63. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Vastert SJ, Kuis W and Grom AA: Systemic JIA: new developments in the understanding of the pathophysiology and therapy. Best Pract Res Clin Rheumatol. 23:655–664. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Nusman CM, van den Berg JM, Schonenberg-Meinema D, et al: Juvenile idiopathic arthritis: from biomarker to treatment. Ned Tijdschr Geneeskd. 157:A63912013.[(In Dutch)]. PubMed/NCBI

6 

Goldzweig O and Hashkes PJ: Abatacept in the treatment of polyarticular JIA: development, clinical utility, and place in therapy. Drug Des Devel Ther. 5:61–70. 2011.PubMed/NCBI

7 

Carreno BM and Collins M: The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Ann Rev Immunol. 20:29–53. 2002. View Article : Google Scholar

8 

McCoy KD and Le Gros G: The role of CTLA-4 in the regulation of T cell immune responses. Immunol Cell Biol. 77:1–10. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Pediatric Rheumatology Collaborative Study Group in China: Diagnosis and treatment of pediatric rheumatic diseases: a consensus statement (I). Lin Chuang Er Ke Za Zhi. 28:984–991. 2010.[(In Chinese)].

10 

He XZ: Juvenile idiopathic arthritis. Edmonton, Canada, 2001 (Draft for new classification standard for International Society of Rheumatology). Zhonghua Feng Shi Bing Xue Za Zhi. 6:62–63. 2002.[(In Chinese)].

11 

Hu YM and Jiang ZF: Zhu Futang Practical Pediatrics. 7th. People's Medical Publishing House; Beijing: pp. 667–672. 2002

12 

Grom AA and Hirsch R: T-cell and T-cell receptor abnormalities in the immunopathogenesis of juvenile rheumatoid arthritis. Curr Opin Rheumatol. 12:420–424. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Wang LL, Li LX, Liu Z and Feng WH: Relationship between disequilibrium of T lymphocyte subgroups and inflammatory adhesion molecules in patients with rheumatoid arthritis. Mian Yi Xue Za Zhi. 18:378–380. 2002.[(In Chinese)].

14 

Li YJ and Dong WL: The last advances of study on the B7 family members. Guo Ji Mian Yi Xue Za Zhi. 34:221–226. 2011.[(In Chinese)].

15 

Goëb V, Buch MH, Vital EM and Emery P: Costimulation blockade in rheumatic diseases: where we are? Curr Opin Rheumatol. 21:244–250. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Rodríguez-Palmero M, Franch A, Castell M, et al: Effective treatment of adjuvant arthritis with a stimulatory CD28-specific monoclonal antibody. J Rheumatol. 33:110–118. 2006.PubMed/NCBI

17 

Qi JJ, Zhang P and Xiong XH: Relationship between abnormality of costimulative molecular expression and imbalanced immune function in patients with rheumatoid arthritis. Lin Chuang Hui Cui. 22:174–176. 2007.[(In Chinese)].

18 

Brunet JF, Denizot F, Luciani MF, et al: A new member of the immunoglobulin superfamily – CTLA-4. Nature. 328:267–270. 1987. View Article : Google Scholar : PubMed/NCBI

19 

Chang TT, Kuchroo VK and Sharp AH: Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr Dir Autoimmun. 5:113–130. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Linsley PS, Greene JL, Brady W, et al: Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity. 1:793–801. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Colucci F, Bergman ML, Penha-Gonçalves C, et al: Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. Proc Natl Acad Sci USA. 94:8670–8674. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Matsui T, Kurokawa M, Kobata T, et al: Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases. J Immunol. 162:4328–4335. 1999.PubMed/NCBI

23 

Zhang SH, Han YX and Wu JB: Expression of co-stimulatory molecules CD28/CTLA-4:B7 in peripheral blood lymphocytes of patients with ankylosing spondylitis. Zhejiang Yi Xu. 28:800–802. 2006.[(In Chinese)].

24 

Duftner C, Dejaco C, Kullich W, et al: Preferential type 1 chemokine receptors and cytokine production of CD 28-T cells in ankylosing spondylitis. Ann Rheum Dis. 65:647–653. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zhang R, Jiang L, Li SF, et al: Expression of 4-1BB on T lymphocytes and relationship with TH1/TH2 cytokines from patients with rheumatoid arthritis. Zhonghua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi. 27:285–288. 2007.[(In Chinese)].

26 

Vallejo AN, Nestel AR, Schirmer M, et al: Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity. J Biol Chem. 273:8119–8129. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Posnett DN, Sinha R, Kabak S and Russo C: Clonal populations of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med. 179:609–618. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Effros RB: Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Dev Comp Immunol. 21:471–478. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Weyand CM, Fulbright JW and Goronzy JJ: Immunosenescence, autoimmunity, and rheumatoid arthritis. Exp Gerontol. 38:833–841. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Vallejo AN, Weyand CM and Goronzy JJ: T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol Med. 10:119–124. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Liang H, Guan H and Liu H: Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis. Exp Ther Med 9: 1733-1738, 2015.
APA
Zhang, L., Liang, H., Guan, H., & Liu, H. (2015). Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis. Experimental and Therapeutic Medicine, 9, 1733-1738. https://doi.org/10.3892/etm.2015.2295
MLA
Zhang, L., Liang, H., Guan, H., Liu, H."Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis". Experimental and Therapeutic Medicine 9.5 (2015): 1733-1738.
Chicago
Zhang, L., Liang, H., Guan, H., Liu, H."Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1733-1738. https://doi.org/10.3892/etm.2015.2295
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Liang H, Guan H and Liu H: Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis. Exp Ther Med 9: 1733-1738, 2015.
APA
Zhang, L., Liang, H., Guan, H., & Liu, H. (2015). Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis. Experimental and Therapeutic Medicine, 9, 1733-1738. https://doi.org/10.3892/etm.2015.2295
MLA
Zhang, L., Liang, H., Guan, H., Liu, H."Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis". Experimental and Therapeutic Medicine 9.5 (2015): 1733-1738.
Chicago
Zhang, L., Liang, H., Guan, H., Liu, H."Study of the association between CD28/CTLA-4 expression and disease activity in juvenile idiopathic arthritis". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1733-1738. https://doi.org/10.3892/etm.2015.2295
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team