|
1
|
Siegel R, Naishadham D and Jemal A: Cancer
statistics 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Chen GG, Merchant JL, Lai P, Ho RL, Hu X,
Okada M, et al: Mutation of p53 in recurrent hepatocellular
carcinoma and its association with the expression of ZBP-89. Am J
Pathol. 162:1823–1829. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Wiesenauer CA, Yip-Schneider MT, Wang Y
and Schmidt CM: Multiple anticancer effects of blocking MEK-ERK
signaling in hepatocellular carcinoma. J Am Coll Surg. 198:410–421.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Li W, Tan D, Zhang Z, Liang JJ and Brown
RE: Activation of Akt-mTOR-p70S6K pathway in angiogenesis in
hepatocellular carcinoma. Oncol Rep. 20:713–719. 2008.PubMed/NCBI
|
|
6
|
Teufel A, Staib F, Kanzler S, Weinmann A,
Schulze-Bergkamen H and Galle PR: Genetics of hepatocellular
carcinoma. World J Gastroenterol. 13:22712007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Polakis P: Wnt signaling and cancer. Genes
Dev. 14:1837–1851. 2000.PubMed/NCBI
|
|
8
|
Fatima S, Lee NP and Luk JM: Dickkopfs and
Wnt/β-catenin signalling in liver cancer. World J Clin Oncol.
2:311–325. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Esufali S and Bapat B: Cross-talk between
Rac1 GTPase and dysregulated Wnt signaling pathway leads to
cellular redistribution of β-catenin and TCF/LEF-mediated
transcriptional activation. Oncogene. 23:8260–8271. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Morgensztern D and McLeod HL:
PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer
Drugs. 16:797–803. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Guertin DA and Sabatini DM: Defining the
role of mTOR in cancer. Cancer Cell. 12:9–22. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Iriye R, Furukawa K, Nishida R, KiM CS and
Fukami H: Isolation and synthesis of a new bio-antimutagen,
petasiphenol, from scapes of Petasites japonicum. Biosci Biotechnol
Biochem. 56:1773–1775. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Schoental R: Toxicology and carcinogenic
action of pyrrolizidine alkaloids. Cancer Res. 28:2237–2246.
1968.PubMed/NCBI
|
|
14
|
Lee JS, Yang EJ, Yun CY, Kim DH and Kim
IS: Suppressive effect of Petasites japonicus extract on
ovalbumin-induced airway inflammation in an asthmatic mouse model.
J Ethnopharmacol. 133:551–557. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lee KP, Kang S, Park SJ, Choi YW, Lee YG
and Im DS: Anti-allergic and anti-inflammatory effects of
bakkenolide B isolated from Petasites japonicus leaves. J
Ethnopharmacol. 148:890–894. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Heo BG, Park YS, Chon SU, Lee SY, Cho JY
and Gorinstein S: Antioxidant activity and cytotoxicity of methanol
extracts from aerial parts of Korean salad plants. Biofactors.
30:79–89. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Kang HG, Jeong SH and Cho JH:
Antimutagenic and anticarcinogenic effect of methanol extracts of
Petasites japonicus Maxim leaves. J Vet Sci. 11:51–58. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Hirono I, Mori H, Yamada K, Hirata Y and
Haga M: Carcinogenic activity of petasitenine, a new pyrrolizidine
alkaloid isolated from Petasites japonicus Maxim. J Natl Cancer
Inst. 58:1155–1157. 1977.PubMed/NCBI
|
|
19
|
Murayama K, Kimura T, Tarutani M, Tomooka
M, Hayashi R, Okabe M, et al: Akt activation induces epidermal
hyperplasia and proliferation of epidermal progenitors. Oncogene.
26:4882–4888. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang
Y, Zhang X, et al: TSC2 integrates Wnt and energy signals via a
coordinated phosphorylation by AMPK and GSK3 to regulate cell
growth. Cell. 126:955–968. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Chen RH, Ding WV and McCormick F: Wnt
signaling to beta-catenin involves two interactive components.
Glycogen synthase kinase-3beta inhibition and activation of protein
kinase C. J Biol Chem. 275:17894–17899. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Whittaker S, Marais R and Zhu AX: The role
of signaling pathways in the development and treatment of
hepatocellular carcinoma. Oncogene. 29:4989–5005. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Cadigan KM and Nusse R: Wnt signaling: a
common theme in animal development. Genes Dev. 11:3286–3305. 1997.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kim D and Chung J: Akt: versatile mediator
of cell survival and beyond. J Biochem Mol Biol. 35:106–115. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Fukumoto S, Hsieh CM, Maemura K, Layne MD,
Yet SF, Lee KH, et al: Akt participation in the Wnt signaling
pathway through Dishevelled. J Biol Chem. 276:17479–17483. 2001.
View Article : Google Scholar : PubMed/NCBI
|
