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Article

Metabolic regulation of magnolol on the nuclear receptor, liver X receptor

  • Authors:
    • Na Xie
    • Chunyang Hu
    • Anran Guo
    • Hao Liang
    • Pengcheng Du
    • Guotian Yin
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453000, P.R. China, Department of Internal Medicine, Luyi Xian People's Hospital, Zhoukou, Henan 477200, P.R. China
  • Pages: 1827-1830
    |
    Published online on: February 17, 2015
       https://doi.org/10.3892/etm.2015.2300
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Abstract

The aim of the present study was to investigate whether magnolol, the essential component of the traditional Chinese medicine, Magnolia officinalis, can pass through liver X receptor α (LXRα), to subsequently play an important role in the lipid metabolic balance. Using a HepG2 human hepatoma cell line, mammalian cellular one‑hybridization and mammalian cell transcriptional activation experiments were performed to detect the combination degree of magnolol at different concentrations with LXRα, and assess the transcriptional activity. In addition, using a THP‑1 human monocytic cell line, quantitative polymerase chain reaction was performed to assess the effect on the expression levels of downstream genes. Magnolol was shown to dose‑dependently combine with LXRα, and subsequently regulate the transcriptional activity of LXRα. In addition, magnolol was found to adjust the expression of associated LXRα downstream genes in the macrophages. In conclusion, magnolol was demonstrated to affect LXRα, which may outline a new molecular mechanism through which magnolol exerts a lipid‑lowering function.
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Copy and paste a formatted citation
Spandidos Publications style
Xie N, Hu C, Guo A, Liang H, Du P and Yin G: Metabolic regulation of magnolol on the nuclear receptor, liver X receptor. Exp Ther Med 9: 1827-1830, 2015.
APA
Xie, N., Hu, C., Guo, A., Liang, H., Du, P., & Yin, G. (2015). Metabolic regulation of magnolol on the nuclear receptor, liver X receptor. Experimental and Therapeutic Medicine, 9, 1827-1830. https://doi.org/10.3892/etm.2015.2300
MLA
Xie, N., Hu, C., Guo, A., Liang, H., Du, P., Yin, G."Metabolic regulation of magnolol on the nuclear receptor, liver X receptor". Experimental and Therapeutic Medicine 9.5 (2015): 1827-1830.
Chicago
Xie, N., Hu, C., Guo, A., Liang, H., Du, P., Yin, G."Metabolic regulation of magnolol on the nuclear receptor, liver X receptor". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1827-1830. https://doi.org/10.3892/etm.2015.2300
Copy and paste a formatted citation
x
Spandidos Publications style
Xie N, Hu C, Guo A, Liang H, Du P and Yin G: Metabolic regulation of magnolol on the nuclear receptor, liver X receptor. Exp Ther Med 9: 1827-1830, 2015.
APA
Xie, N., Hu, C., Guo, A., Liang, H., Du, P., & Yin, G. (2015). Metabolic regulation of magnolol on the nuclear receptor, liver X receptor. Experimental and Therapeutic Medicine, 9, 1827-1830. https://doi.org/10.3892/etm.2015.2300
MLA
Xie, N., Hu, C., Guo, A., Liang, H., Du, P., Yin, G."Metabolic regulation of magnolol on the nuclear receptor, liver X receptor". Experimental and Therapeutic Medicine 9.5 (2015): 1827-1830.
Chicago
Xie, N., Hu, C., Guo, A., Liang, H., Du, P., Yin, G."Metabolic regulation of magnolol on the nuclear receptor, liver X receptor". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1827-1830. https://doi.org/10.3892/etm.2015.2300
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