Association between preeclampsia and the CXC chemokine family (Review)

  • Authors:
    • Xijing Liu
    • Li Dai
    • Rong Zhou
  • View Affiliations

  • Published online on: March 9, 2015     https://doi.org/10.3892/etm.2015.2337
  • Pages: 1572-1576
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Abstract

Preeclampsia is a major cause of maternal and perinatal mortality and morbidity, characterized by gestational hypertension, proteinuria, systemic endothelial cell activation and an exaggerated inflammatory response. The precise cause of preeclampsia is not currently known; however, it is widely accepted that the pathogenesis of preeclampsia involves inadequate trophoblast invasion, leading to generalized endothelial dysfunction and an exaggerated inflammatory response. Chemokines are a superfamily of structurally similar proteins that mediate cell recruitment, angiogenesis, immunity and stem cell trafficking. CXC chemokines are a family of cytokines, unique in their ability to behave in a disparate manner in the regulation of angiogenesis. The CXC chemokine family further divides into two subfamilies; CXC ELR+, which promotes angiogenesis, and CXC ELR-, which inhibits angiogenesis. Furthermore, CXC chemokines are involved in the pathogenesis of various conditions, including malignant tumors, wound repair, chronic inflammation, atherosclerosis and potentially preeclampsia.
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May-2015
Volume 9 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu X, Dai L and Zhou R: Association between preeclampsia and the CXC chemokine family (Review). Exp Ther Med 9: 1572-1576, 2015
APA
Liu, X., Dai, L., & Zhou, R. (2015). Association between preeclampsia and the CXC chemokine family (Review). Experimental and Therapeutic Medicine, 9, 1572-1576. https://doi.org/10.3892/etm.2015.2337
MLA
Liu, X., Dai, L., Zhou, R."Association between preeclampsia and the CXC chemokine family (Review)". Experimental and Therapeutic Medicine 9.5 (2015): 1572-1576.
Chicago
Liu, X., Dai, L., Zhou, R."Association between preeclampsia and the CXC chemokine family (Review)". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1572-1576. https://doi.org/10.3892/etm.2015.2337