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Article

Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery

  • Authors:
    • Tiandong Li
    • Hongmin Bai
    • Guoliang Wang
    • Weimin Wang
    • Jian Lin
    • Han Gao
    • Limin Wang
    • Lihui Xia
    • Xuemin Xie
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Liuhuaqiao Hospital, Guangzhou, Guangdong 510010, P.R. China
  • Pages: 1962-1966
    |
    Published online on: March 16, 2015
       https://doi.org/10.3892/etm.2015.2359
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Abstract

The aim of this study was to investigate the method and significance of the application of direct electrical stimulation (DES) to the brain mapping of language functions during glioma surgery. A retrospective analysis of clinical data was performed for 91 cases of brain functional area glioma surgery under DES from January 2003 until January 2012. Following cortical electrical stimulation, 88 patients exhibited seizures involving facial or hand movements and 91 cases experienced language disorders such as counting interruption, naming errors or anomia. The most commonly observed areas of counting interruption were distributed on the posterior part of the left anterior central gyrus (47.7%), the operculum of the left inferior frontal gyrus (24.4%) and the triangular part of the left inferior frontal gyrus (12.8%). Postoperative magnetic resonance imaging demonstrated that overall excision was achieved in 53 cases and sub‑overall excision was performed in 31 cases. A total of 42 cases (46.2%) exhibited no postoperative neurological dysfunction, 39 cases (42.9%) exhibited brief language dysfunction, 27 cases (29.7%) experienced brief limb movement disorder, and one case appeared to have permanent neurological dysfunction. DES was indicated to be a reliable and noninvasive method for the intraoperative positioning of language areas, and was able to resect gliomas in the language area with maximal safety.
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1 

Chan-Seng E, Moritz-Gasser S and Duffau H: Awake mapping for low-grade gliomas involving the left sagittal stratum: Anatomofunctional and surgical considerations. J Neurosurg. 120:1069–1077. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Sanai N and Berger MS: Glioma extent of resection and its impact on patient outcome. Neurosurgery. 62:753–764. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Han SJ and Sughrue ME: The rise and fall of ‘biopsy and radiate’: A history of surgical nihilism in glioma treatment. Neurosurg Clin N Am. 23:207–214. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Giussani C, Roux FE, Ojemann J, Sganzerla EP, Pirillo D and Papagno C: Is preoperative functional magnetic resonance imaging reliable for language areas mapping in brain tumor surgery? Review of language functional magnetic resonance imaging and direct cortical stimulation correlation studies. Neurosurgery. 66:113–120. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Choi BD, Mehta AI, Batich KA, Friedman AH and Sampson JH: The use of motor mapping to aid resection of eloquent gliomas. Neurosurg Clin N Am. 23:215–225. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Lubrano V, Draper L and Roux FE: What makes surgical tumor resection feasible in Broca's area? Insights into intraoperative brain mapping. Neurosurgery. 66:868–875. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Mandonnet E, Winkler PA and Duffau H: Direct electrical stimulation as an input gate into brain functional networks: Principles, advantages and limitations. Acta Neurochir (Wien). 152:185–193. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Duffau H: Awake surgery for nonlanguage mapping. Neurosurgery. 66:523–528. 2010. View Article : Google Scholar : PubMed/NCBI

9 

De Witt Hamer PC, Robles SG, Zwinderman AH, Duffau H and Berger MS: Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol. 30:2559–2565. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Tan LH, Spinks JA, Eden GF, Perfetti CA and Siok WT: Reading depends on writing, in Chinese. Proc Natl Acad Sci USA. 102:8781–8785. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Bai HM, Wang WM, Li TD, et al: Three core techniques in surgery of neuroepithelial tumors in eloquent areas: awake anaesthesia, intra-operative direct electrical stimulation and ultrasonography. Chin Med J (Engl). 124:3035–3041. 2011.PubMed/NCBI

12 

Bai HM, Jiang T, Wang WM, Li TD, Liu Y and Lu YC: Functional MRI mapping of category-specific sites associated with naming of famous faces, animals and man-made objects. Neurosci Bull. 27:307–318. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Oldfield RC: The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia. 9:97–113. 1971. View Article : Google Scholar : PubMed/NCBI

14 

Zhou LF, Wang RZ, Bao SD, et al: Chinese guideline for diagnosis and treatment on central nervous system tumors. Zhonghua Yi Xue Za Zhi. 92:2309–2313. 2012.[(In Chinese)].

15 

Kim SS, McCutcheon IE, Suki D, et al: Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcomes in 309 consecutive patients. Neurosurgery. 64:836–845. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Sacko O, Lauwers-Cances V, Brauge D, Sesay M, Brenner A and Roux FE: Awake craniotomy vs surgery under general anesthesia for resection of supratentorial lesions. Neurosurgery. 68:1192–1198. 2011.PubMed/NCBI

17 

De Benedictis A, Moritz-Gasser S and Duffau H: Awake mapping optimizes the extent of resection for low-grade gliomas in eloquent areas. Neurosurgery. 66:1074–1084. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Fritsch G and Hitzig E: Electric excitability of the cerebrum (Uber die elektrische Erregbarkeit des Grosshirns). Epilepsy Behav. 15:123–130. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Bartholow R: Experimental investigations into the functions of the human brain. Am J Med Sci. 66:305–313. 1874. View Article : Google Scholar

20 

Penfield W and Flanigin H: Surgical therapy of temporal lobe seizures. AMA Arch Neurol Psychiatry. 64:491–500. 1950. View Article : Google Scholar : PubMed/NCBI

21 

Berger MS, Stieg PE, Danks RA, Schwartz RB and Folkerth RD: Lesions in eloquent cortex. Neurosurgery. 40:1059–1063. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Duffau H: Surgery of low-grade gliomas: Towards a ‘functional neurooncology’. Curr Opin Oncol. 21:543–549. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Ilmberger J, Ruge M, Kreth FW, Briegel J, Reulen HJ and Tonn JC: Intraoperative mapping of language functions: A longitudinal neurolinguistic analysis. J Neurosurg. 109:583–592. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Desmurget M, Reilly KT, Richard N, Szathmari A, Mottolese C and Sirigu A: Movement intention after parietal cortex stimulation in humans. Science. 324:811–813. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Roux FE, Dufor O, Lauwers-Cances V, et al: Electrostimulation mapping of spatial neglect. Neurosurgery. 69:1218–1231. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Beez T, Boge K, Wager M, et al: European Low Grade Glioma Network: Tolerance of awake surgery for glioma: A prospective European Low Grade Glioma Network multicenter study. Acta Neurochir (Wien). 155:1301–1308. 2013. View Article : Google Scholar : PubMed/NCBI

27 

De Benedictis A, Sarubbo S and Duffau H: Subcortical surgical anatomy of the lateral frontal region: Human white matter dissection and correlations with functional insights provided by intraoperative direct brain stimulation: laboratory investigation. J Neurosurg. 117:1053–1069. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Duffau H: A new concept of diffuse (low-grade) glioma surgery. Adv Tech Stand Neurosurg. 38:3–27. 2012.PubMed/NCBI

29 

Lüders HO: Symptomatic Areas and Electrical Cortical StimulationNew York: Churchill Livingstone; 2000

30 

Duffau H: Awake surgery for incidental WHO grade II gliomas involving eloquent areas. Acta Neurochir (Wien). 154:575–584. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Duffau H: Brain mapping in tumors: Intraoperative or extraoperative? Epilepsia. 54:79–83. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Duffau H: A new philosophy in surgery for diffuse low-grade glioma (DLGG): Oncological and functional outcomes. Neurochirurgie. 59:2–8. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Duffau H and Mandonnet E: The ‘onco-functional balance’ in surgery for diffuse low-grade glioma: Integrating the extent of resection with quality of life. Acta Neurochir (Wien). 155:951–957. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Gras-Combe G, Moritz-Gasser S, Herbet G and Duffau H: Intraoperative subcortical electrical mapping of optic radiations in awake surgery for glioma involving visual pathways. J Neurosurg. 117:466–473. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Klein M, Duffau H and De Witt Hamer PC: Cognition and resective surgery for diffuse infiltrative glioma: An overview. J Neurooncol. 108:309–318. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Maldonado IL, Moritz-Gasser S, de Champfleur NM, Bertram L, Moulinié G and Duffau H: Surgery for gliomas involving the left inferior parietal lobule: new insights into the functional anatomy provided by stimulation mapping in awake patients. J Neurosurg. 115:770–779. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Pallud J, Mandonnet E and Duffau H: Diffuse low-grade gliomas and UCSF scores. J Neurosurg. 120:577–578. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Schucht P, Ghareeb F and Duffau H: Surgery for low-grade glioma infiltrating the central cerebral region: location as a predictive factor for neurological deficit, epileptological outcome and quality of life. J Neurosurg. 119:318–323. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Yordanova YN, Moritz-Gasser S and Duffau H: Awake surgery for WHO Grade II gliomas within ‘noneloquent’ areas in the left dominant hemisphere: toward a ‘supratotal’ resection. Clinical article. J Neurosurg. 115:232–239. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li T, Bai H, Wang G, Wang W, Lin J, Gao H, Wang L, Xia L and Xie X: Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery. Exp Ther Med 9: 1962-1966, 2015.
APA
Li, T., Bai, H., Wang, G., Wang, W., Lin, J., Gao, H. ... Xie, X. (2015). Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery. Experimental and Therapeutic Medicine, 9, 1962-1966. https://doi.org/10.3892/etm.2015.2359
MLA
Li, T., Bai, H., Wang, G., Wang, W., Lin, J., Gao, H., Wang, L., Xia, L., Xie, X."Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery". Experimental and Therapeutic Medicine 9.5 (2015): 1962-1966.
Chicago
Li, T., Bai, H., Wang, G., Wang, W., Lin, J., Gao, H., Wang, L., Xia, L., Xie, X."Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1962-1966. https://doi.org/10.3892/etm.2015.2359
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Bai H, Wang G, Wang W, Lin J, Gao H, Wang L, Xia L and Xie X: Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery. Exp Ther Med 9: 1962-1966, 2015.
APA
Li, T., Bai, H., Wang, G., Wang, W., Lin, J., Gao, H. ... Xie, X. (2015). Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery. Experimental and Therapeutic Medicine, 9, 1962-1966. https://doi.org/10.3892/etm.2015.2359
MLA
Li, T., Bai, H., Wang, G., Wang, W., Lin, J., Gao, H., Wang, L., Xia, L., Xie, X."Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery". Experimental and Therapeutic Medicine 9.5 (2015): 1962-1966.
Chicago
Li, T., Bai, H., Wang, G., Wang, W., Lin, J., Gao, H., Wang, L., Xia, L., Xie, X."Glioma localization and excision using direct electrical stimulation for language mapping during awake surgery". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1962-1966. https://doi.org/10.3892/etm.2015.2359
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