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Article

Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model

  • Authors:
    • Mao‑Lin Hao
    • Ning Pan
    • Qing‑Hua Zhang
    • Xiao‑Hong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250031, P.R. China
  • Pages: 1887-1894
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    Published online on: March 17, 2015
       https://doi.org/10.3892/etm.2015.2367
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Abstract

The aim of the present study was to determine whether chlorogenic acid (CA) is able to modulate cadmium (Cd)‑induced oxidative brain damage. Cd‑treated rats displayed numerous pathological effects, including the inhibition of acetylcholinesterase, elevated lipid peroxidation, the depletion of enzymatic and non‑enzymatic antioxidants, the reduction of membrane‑bound ATPase activity, mitochondrial dysfunction and DNA fragmentation. Pretreatment of the rats with CA significantly attenuated these effects. These results lead to the hypothesis that the mechanisms by which CA attenuates the effects of Cd‑induced oxidative brain damage include the maintenance of antioxidant homeostasis, inhibition of the membrane effects and the perpetuation of mitochondrial dysfunction. These data support the potential of CA as a beneficial intervention in the prevention of heavy metal poisoning due to Cd exposure.
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1 

Brender JD, Suarez L, Felkner M, et al: Maternal exposure to arsenic, cadmium, lead, and mercury and neural tube defects in offspring. Environ Res. 101:132–139. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Jadhav SH, Sarkar SN, Patil RD and Tripathi HC: Effects of subchronic exposure via drinking water to a mixture of eight water contaminating metals: a biochemical and histopathological study in male rats. Arch Environ Contam Toxicol. 53:667–677. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Nawrot T, Plusquin M, Hogervorst J, et al: Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol. 7:119–126. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Fowler BA: Monitoring of human populations forearly markers of cadmium toxicity; a review. Toxicol Appl Pharmacol. 238:294–300. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Shukla A, Shukla GS and Srimal RC: Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat. Hum Exp Toxicol. 15:400–405. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Abu-Taweel GM, Ajarem JS and Ahmad M: Protective effect of curcumin on anxiety, learning behavior, neuromuscular activities, brain neurotransmitters and oxidative stress enzymes in cadmium intoxicated mice. Behav Brain Sci. 3:74–84. 2013. View Article : Google Scholar

7 

Carageorgiou H, Tzotzes V, Pantos C, Mourouzis C, Zarros A and Tsakiris S: In vivo and in-vitro effects of cadmium on adult rat brain total antioxidant status, acetylcholinesterase, (Na+, K+)-ATPase and Mg2+-ATPase activities: protection by L-cysteine. Basic Clin Pharmacol Toxicol. 94:112–118. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Lopez E, Arce C, Oset-Gasque MJ, Cañadas S and González MP: Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radical Biol Med. 40:940–951. 2006. View Article : Google Scholar

9 

Kasprzak KS: Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis. Free Radical Biol Med. 32:958–967. 2002. View Article : Google Scholar

10 

Kasai H, Fukada S, Yamaizumi Z, Sugie S and Mori H: Action of chlorogenic acid in vegetables and fruits as an inhibitor of 8-hydroxydeoxyguanosine formation in vitro and in a rat carcinogenesis model. Food Chem Toxicol. 38:467–471. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Suzuki A, Yamamoto N, Jokura H, et al: Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens. 24:1065–1073. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Shibata H, Sakamoto Y, Oka M and Kono Y: Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine. Biosci Biotechnol Biochem. 63:1295–1297. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Gonthier MP, Verny MA, Besson C, Rémésy C and Scalbert A: Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr. 133:1853–1859. 2003.PubMed/NCBI

14 

Rice-Evans CA, Miller NJ and Paganga G: Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biol Med. 20:933–956. 1996. View Article : Google Scholar

15 

Cheng JC, Dai F, Zhou B, Yang L and Liu ZL: Antioxidant activity of hydroxycinnamic acid derivatives in human low density lipoprotein: mechanism and structure-activity relationship. Food Chem. 104:132–139. 2007. View Article : Google Scholar

16 

López-Giraldo LJ, Laguerre M, Lecomte J, et al: Kinetic and stoichiometry of the reaction of chlorogenic acid and its alkyl esters against the DPPH radical. J Agric Food Chem. 57:863–870. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Sato Y, Itagaki S, Kurokawa T, et al: In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm. 403:136–138. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Wang GF, Shi LP, Ren YD, et al: Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res. 83:186–190. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Gordon MH and Wishart K: Effects of chlorogenic acid and bovine serum albumin on the oxidative stability of low density lipoproteins in vitro. J Agric Food Chem. 58:5828–5833. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Tang YZ and Liu ZQ: Chemical kinetic behavior of chlorogenic acid in protecting erythrocyte and DNA against radical-induced oxidation. J Agric Food Chem. 56:11025–11029. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Nakajima Y, Shimazawa M, Mishima S and Hara H: Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. Life Sci. 80:370–377. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Li Y, Shi W, Li Y, et al: Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury. Environ Toxicol Pharmacol. 26:13–21. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Vardi N, Parlakpinar H and Ates B: Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats. J Chem Neuroanat. 43:43–47. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Johnson D and Lardy H: Isolation of liver or kidney mitochondria. Methods Enzymol. 10:94–96. 1967. View Article : Google Scholar

25 

Ellman GL, Courtney KD, Andres VJ Jr and Feather-stone RM: A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmcol. 7:88–95. 1961. View Article : Google Scholar

26 

Kakkar P, Das B and Viswanathan PN: A modified spectrophotometric assay of superoxide dismutase. Ind J Biochem Biophys. 21:130–132. 1984.

27 

Sinha AK: Colorimetric assay of catalase. Anal Biochem. 47:389–394. 1972. View Article : Google Scholar : PubMed/NCBI

28 

Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG and Hoekstra WG: Selenium: biochemical role as a component of glutathione peroxidase. Science. 179:588–590. 1973. View Article : Google Scholar : PubMed/NCBI

29 

Habig WH, Pabst MJ and Jakoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 249:7130–7139. 1974.PubMed/NCBI

30 

Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–275. 1951.PubMed/NCBI

31 

Moron MS, Depierre JW and Mannervik B: Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta. 582:67–78. 1979. View Article : Google Scholar : PubMed/NCBI

32 

Omaye ST, Turnbull JD and Sauberlich HE: Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol. 62:3–8. 1979. View Article : Google Scholar : PubMed/NCBI

33 

Desai ID: Vitamin E analysis methods for animal tissues. Methods Enzymol. 105:138–147. 1984. View Article : Google Scholar : PubMed/NCBI

34 

Ohkawa H, Ohishi N and Yagi K: Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358. 1979. View Article : Google Scholar : PubMed/NCBI

35 

Bonting SL: Presence of enzyme systems in mammalian tissuesMembrane and Ion Transport. Bilter EE: Wiley Interscience; London: pp. 257–263. 1970

36 

Ohinishi T, Suzuki T, Suzuki Y and Ozawa K: A comparative study of plasma membrane Mg2+ ATPase activities in normal, regenerating and malignant cells. Biochem Biophys Acta. 684:67–74. 1982. View Article : Google Scholar : PubMed/NCBI

37 

Hjertan S and Pan H: Purification and characterization of two forms of a low affinity Ca2+-ATPase from erythrocyte membranes. Biochim Biophys Acta. 728:281–288. 1983. View Article : Google Scholar : PubMed/NCBI

38 

Reed LJ and Mukherjee BB: α-ketoglutarate dehydrogenase complex from Escherichia coli. Methods Enzymol. 113:55–61. 1969. View Article : Google Scholar

39 

King J: The hydrolases - acid and alkaline phosphatasesPractical Clinical Enzymology. Van D Nostrand Co.; London: pp. 199–208. 1965

40 

Nulton-Persson AC and Szweda LI: Modulation of mitochondrial function by hydrogen peroxide. J Biol Chem. 276:23357–23361. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Mehler AH, Kornberg A, Grisolia S and Ochoa S: The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate. J Biol Chem. 174:961–977. 1948.PubMed/NCBI

42 

Watabe M, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y and Nakaya K: The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells. J Biol Chem. 271:14067–14072. 1996. View Article : Google Scholar : PubMed/NCBI

43 

Bondy SC: Free-radical-mediated toxic injury to the nervous systemIn: Free Radical Toxicology. Wallace KB: Taylor and Francis; Oxford: pp. 221–248. 1997

44 

Emerit J, Edeas M and Bricaire F: Neurodegenerative diseases and oxidative stress. Biomed Pharmacother. 58:39–46. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Gandhi S and Abramov AY: Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012:4280102012. View Article : Google Scholar : PubMed/NCBI

46 

Kumar R, Agarwal AK and Seth PK: Oxidative stress-mediated neurotoxicity of cadmium. Toxicol Lett. 89:65–69. 1996. View Article : Google Scholar : PubMed/NCBI

47 

Antonio MT, Corredor L and Leret ML: Study of the activity of several brain enzymes like markers of the neurotoxicity induced by perinatal exposure to lead and/or cadmium. Toxicol Lett. 143:331–340. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Tsakiris S, Angelogianni P, Schulpis KH and Starridis JC: Protective effect of L-phenylalanine on rat brain acetylcholinesterase inhibition induced by free radicals. Clin Biochem. 33:103–106. 2000. View Article : Google Scholar : PubMed/NCBI

49 

Olney JW, Collins RC and Sloviter RS: Excitotoxic mechanisms of epileptic brain damage. Adv Neurol. 44:857–877. 1986.PubMed/NCBI

50 

Tomlinson G, Mutus B and McLennan I: Activation and inactivation of acetylcholinesterase by metal ions. Can J Biochem. 59:728–735. 1981. View Article : Google Scholar : PubMed/NCBI

51 

Chu YF, Brown PH, Lyle BJ, et al: Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J Agric Food Chem. 57:9801–9808. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Lapchak PA: The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator. Exp Neurol. 205:407–413. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Stohs SJ and Bagchi D: Oxidative Mechanisms in the toxicity of metal ions. Free Radical Biology and Medi. 18:321–336. 1995. View Article : Google Scholar

54 

Anane R and Creppy EE: Lipid peroxidation as pathway of aluminium cytotoxicity in human skin fibroblast cultures: prevention by superoxide dismutase+catalase and vitamins E and C. Hum Exp Toxicol. 2:477–481. 2001. View Article : Google Scholar

55 

O'Brien P and Salasinski HJ: Evidence that the reactions of cadmium in the presence of metallothionein can produce hydroxyl radicals. Arch Toxicol. 72:690–700. 1998. View Article : Google Scholar : PubMed/NCBI

56 

Koizumi T, Shirakura G, Kumagai H, Tatsumoto H and Suzuki KT: Mechanism of cadmium-induced cytotoxicity in rat hepatocytes: cadmium-induced active oxygen-related permeability changes of the plasma membrane. Toxicology. 114:124–134. 1996. View Article : Google Scholar

57 

Tandom SK, Singh S, Prasad S, et al: Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol Lett. 145:211–217. 2003. View Article : Google Scholar : PubMed/NCBI

58 

Rana SV and Verma S: Protective effects of GSH, vitamin E and selenium on lipid peroxidation in cadmium-fed rats. Biol Trace Elem Res. 51:161–168. 1996. View Article : Google Scholar : PubMed/NCBI

59 

Dringen R, Gutterer JM and Hirrlinger J: Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem. 267:4912–4916. 2000. View Article : Google Scholar : PubMed/NCBI

60 

Hidalgo J, Aschner M, Zatta P and Vasák M: Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull. 15:133–145. 2001. View Article : Google Scholar

61 

Waisberg M, Joseph P, Hale B and Beyersmann D: Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology. 192:95–117. 2003. View Article : Google Scholar : PubMed/NCBI

62 

Jamall IS and Sprowls JJ: Effects of cadmium and dietary selenium on cytoplasmic and mitochondrial antioxidant defense systems in the heart of rats fed high dietary copper. Toxicol Appl Pharmacol. 87:102–110. 1987. View Article : Google Scholar : PubMed/NCBI

63 

Sarkar S, Yadov P and Bhatnagar D: Lipid peroxidative damage on cadmium exposure and alterations in antioxidant system in rat erythrocytes: A study with relation to time. Biometals. 11:153–157. 1998. View Article : Google Scholar : PubMed/NCBI

64 

Casalino E, Calzaretti G, Sblano C and Landriscina C: Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology. 179:37–50. 2002. View Article : Google Scholar : PubMed/NCBI

65 

Pari L, Karthikesan K and Menon VP: Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes. Mol Cell Biochem. 341:109–117. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Bogdanski DF, Tissuri A and Brodie BB: Role of sodium, potassium, ouabain and reserpine in uptake, storage and metabolism of biogenic amines in synaptosomes. Life Sci. 7:419–428. 1968. View Article : Google Scholar : PubMed/NCBI

67 

Mata M, Fink DJ, Gainer H, et al: Activity-dependent energy metabolism in rat posterior pituitary, primarily reflects sodium pump activity. J Neurochem. 34:214–215. 1980. View Article : Google Scholar

68 

Hernandez R: Brain Na+, K+-ATPase activity possibly regulated by a specific serotonin receptor. Brain Res. 408:399–402. 1989. View Article : Google Scholar

69 

Skalska J, Bednarczyk P, Piwońska M, et al: Calcium ions regulate K+ uptake into brain mitochondria: The evidence for a novel potassium channel. Int J Mol Sci. 10:1104–1120. 2009. View Article : Google Scholar : PubMed/NCBI

70 

Sanui H and Rubin H: The role of magnesium in cell proliferation and transformationIons, Cell Proliferation and Cancer. Boynton AL, McKochan WL and Whitfield JP: Academic Press; New York: pp. 517–537. 1982

71 

Rajanna B, Hobson M, Boykin M and Chetty CS: Effects of chronic treatment with cadmium on ATPases, uptake of catecholamines and lipid peroxidation in rat brain synaptosomes. Ecotoxicol Environ Saf. 20:36–41. 1990. View Article : Google Scholar : PubMed/NCBI

72 

Carfagna MA, Ponsler GD and Muhoberac BB: Inhibition of ATPase activity in rat synaptic plasma membranes by simultaneous exposure to metals. Chem Biol Interact. 100:53–65. 1996. View Article : Google Scholar : PubMed/NCBI

73 

El-Missiry MA and Shalaby F: Role of beta-carotene in ameliorating the cadmium-induced oxidative stress in rat brain and testis. J Biochem Mol Toxicol. 14:238–243. 2000. View Article : Google Scholar : PubMed/NCBI

74 

Lee K, Lee JS, Jang HJ, et al: Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia. Eur J Pharmacol. 689:89–95. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Nigam D, Shukla GS and Agarwal AK: Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney. Toxicol Lett. 106:151–157. 1999. View Article : Google Scholar : PubMed/NCBI

76 

Ho L, Varghese M, Wang J, et al: Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice. Nutr Neurosci. 15:37–45. 2012. View Article : Google Scholar : PubMed/NCBI

77 

Xu JG, Hu QP and Liu Y: Antioxidant and DNA-protective activities of chlorogenic acid isomers. J Agric Food Chem. 60:11625–11630. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Chen S, Gu C, Xu C, et al: Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network. J Neurochem. 128:256–266. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hao ML, Pan N, Zhang QH and Wang XH: Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model. Exp Ther Med 9: 1887-1894, 2015.
APA
Hao, M., Pan, N., Zhang, Q., & Wang, X. (2015). Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model. Experimental and Therapeutic Medicine, 9, 1887-1894. https://doi.org/10.3892/etm.2015.2367
MLA
Hao, M., Pan, N., Zhang, Q., Wang, X."Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model". Experimental and Therapeutic Medicine 9.5 (2015): 1887-1894.
Chicago
Hao, M., Pan, N., Zhang, Q., Wang, X."Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1887-1894. https://doi.org/10.3892/etm.2015.2367
Copy and paste a formatted citation
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Spandidos Publications style
Hao ML, Pan N, Zhang QH and Wang XH: Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model. Exp Ther Med 9: 1887-1894, 2015.
APA
Hao, M., Pan, N., Zhang, Q., & Wang, X. (2015). Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model. Experimental and Therapeutic Medicine, 9, 1887-1894. https://doi.org/10.3892/etm.2015.2367
MLA
Hao, M., Pan, N., Zhang, Q., Wang, X."Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model". Experimental and Therapeutic Medicine 9.5 (2015): 1887-1894.
Chicago
Hao, M., Pan, N., Zhang, Q., Wang, X."Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1887-1894. https://doi.org/10.3892/etm.2015.2367
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