A comparison of the effects of midazolam, propofol and dexmedetomidine on the antioxidant system: A randomized trial

Han,Chao; Ding,Weiliang; Jiang,Wenjie; Chen,Yu; Hang,Dongyuan; Gu,Daming; Jiang,Guojun; Tan,Yongfei; Ge,Zhijun; Ma,Tieliang

doi:10.3892/etm.2015.2410

A comparison of the effects of midazolam, propofol and dexmedetomidine on the antioxidant system: A randomized trial

Authors:
- Chao Han
- Weiliang Ding
- Wenjie Jiang
- Yu Chen
- Dongyuan Hang
- Daming Gu
- Guojun Jiang
- Yongfei Tan
- Zhijun Ge
- Tieliang Ma
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Affiliations: Department of Anesthesiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, P.R. China, Central Laboratory, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, P.R. China, Department of Anesthesiology, Jiangsu Province Hospital, Nanjing, Jiangsu 214200, P.R. China, Department of Critical Care Medicine, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, P.R. China, Department of Cardiac and Thoracic Surgery, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, P.R. China
Published online on: April 7, 2015 https://doi.org/10.3892/etm.2015.2410
Pages: 2293-2298

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Abstract

Previous studies on the antioxidant activity of sedatives have predominantly been in vitro investigations that are lacking clinical data, resulting in conclusion without cogency. The aim of the present prospective, randomized study was to use single sedative drugs for anesthesia induction to compare their antioxidant properties. The effects on the antioxidant system of midazolam, propofol and dexmedetomidine were assessed using oxidative stress indicators and micronuclei (MN). Forty‑nine patients undergoing esophageal cancer radical prostatectomy were selected. Midazolam, propofol and dexmedetomidine were used to induce anesthesia. Venous blood samples were obtained prior to and at 2 and at 24 h after surgery, and oxidative stress indicators were detected using the appropriate kits. The cytokinesis‑block micronucleus cytome assay was executed and the frequencies of MN, nucleoplasmic bridges and nuclear buds were examined. It was found that the use of the three sedatives, respectively, led to a marked increase in the levels of free radical indicators at 2 h after surgery, which then decreased at 24 h after surgery. Furthermore, lower levels of oxidative stress were found following the use of propofol and dexmedetomidine compared with those following midazolam administration, and similar results were obtained regarding the level of MN. It is suggested that propofol and dexmedetomidine exhibit a superior antioxidant function to midazolam.

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