Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats

Tian,Ye; Teng,Li‑Rong; Wang,Zhen‑Zuo; Zhao,Min; Meng,Qing‑Fan; Lu,Jia‑Hui; Tian,Jian‑Ming; Zhang,Wei‑Wei; Zheng,Xiaoyi; Wang,Di; Teng,Le‑Sheng

doi:10.3892/etm.2015.2426

June-2015 Volume 9 Issue 6

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June-2015 Volume 9 Issue 6

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Article

Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats

Authors:
- Ye Tian
- Li‑Rong Teng
- Zhen‑Zuo Wang
- Min Zhao
- Qing‑Fan Meng
- Jia‑Hui Lu
- Jian‑Ming Tian
- Wei‑Wei Zhang
- Xiaoyi Zheng
- Di Wang
- Le‑Sheng Teng
View Affiliations / Copyright

Affiliations: College of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China, Jilin Academy of Traditional Chinese Medicine, Changchun, Jilin 130012, P.R. China, Department of Nephrology, School of Medicine, Stanford University, Stanford, CA 94305, USA
Pages: 2349-2355
|
Published online on: April 15, 2015

https://doi.org/10.3892/etm.2015.2426
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Abstract

Jia-Yuan-Qing pill (JYQP) composed of Porcellio laevis Latreille, Corydalis Rhizoma and Radix Cynanchi Paniculati at a ratio of 9:7:7 has been found to be an effective analgesic agent. The present study aimed to evaluate the safety, addictive potential and anti-cancer pain activity of JYQP in a rat model. During the 6‑month chronic toxicity test, no significant changes in general behavior, defecation, postural abnormalities, dietary or water intake or blood biochemical parameters were observed in male and female rats. Although a high dose of JYQP (5 g/kg) caused swelling of the liver, spleen and kidney in male and female rats, no pathological changes were observed in all organs examined via hematoxylin and eosin staining. The analgesic effect of JYQP on bone cancer pain was successfully confirmed in a rat model of Walker 256 cell‑induced bone cancer. In contrast to morphine, in a physical dependence test, JYQP produced no withdrawal symptoms following chronic administration. The data from this study provide experimental evidence supporting the clinical use of JYQP as an effective, safe and non-addictive agent for the treatment of bone cancer pain.

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1	Bali KK, Selvaraj D, Satagopam VP, Lu J, Schneider R and Kuner R: Genome-wide identification and functional analyses of microRNA signatures associated with cancer pain. Embo Mol Med. 5:1740–1758. 2013. View Article : Google Scholar : PubMed/NCBI
2	Coleman RE: Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 12:6243s–6249s. 2006. View Article : Google Scholar : PubMed/NCBI
3	Suh SY, Choi YS, Oh SC, et al: Caffeine as an adjuvant therapy to opioids in cancer pain: A randomized, double-blind, placebo-controlled trial. J Pain Symptom Manag. 46:474–482. 2013. View Article : Google Scholar
4	Mantyh PW: A mechanism-based understanding of bone cancer pain. Novartis Found Symp. 261:194–219; discussion 256–161. 2004. View Article : Google Scholar : PubMed/NCBI
5	Ali S, Mohs A, Thomas M, et al: The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription. J Immunol. 187:1609–1616. 2011. View Article : Google Scholar : PubMed/NCBI
6	Lai JN, Tang JL and Wang JD: Observational studies on evaluating the safety and adverse effects of traditional chinese medicine. Evid Based Complement Alternat Med. 2013:6978932013. View Article : Google Scholar : PubMed/NCBI
7	Yuan HW, Ma LX, Qi DD, Zhang P, Li CH and Zhu J: The historical development of deqi concept from classics of traditional chinese medicine to modern research: Exploitation of the connotation of deqi in Chinese medicine. Evid Based Complement Alternat Med. 2013:6393022013. View Article : Google Scholar : PubMed/NCBI
8	Li JC, Shen XF, Meng XL, Zhang Y and Lai XR: Analgesic effect and mechanism of the three TCM-herbal drug-combination Tou Feng Yu pill on treatment of migraine. Phytomedicine. 18:788–794. 2011. View Article : Google Scholar : PubMed/NCBI
9	Wang J, Zhang R, Dong C, et al: Topical treatment with Tong-Luo-San-Jie gel alleviates bone cancer pain in rats. J Ethnopharmacol. 143:905–913. 2012. View Article : Google Scholar : PubMed/NCBI
10	Gozum S, Tezel A and Koc M: Complementary alternative treatments used by patients with cancer in eastern Turkey. Cancer Nurs. 26:230–236. 2003. View Article : Google Scholar : PubMed/NCBI
11	Teng LR, Wang ZZ, Tian Y, et al: The preparation method of Armadillidium formula extract and the application of which in analgesic drugs. CN Patent 201110147689.7. Filed June 2, 2011; issued. December 19–2012
12	Liang CY and Sun Z: The analgesic effect of Porcellio preparation on moderate to severe cancer pain. Shandong Zhongyi Zazhi. 13:1591601994.(In Chinese).
13	Zhang XH, Lu TL and Mao CQ: Analgesic and anti-inflammatory effects of different kinds of Corydalis yanhusuo. Lishizhen Medicine and Materia Medica Research. 20:4494502009.(In Chinese).
14	Xu QS, Zhang HY, Li YJ and Li D: Effect of the extract of Cynanchum paniculatum on anti-inflammation and analgesic in mice. Lishizhen Medicine and Materia Medica Research. 18:140714082007.(In Chinese).
15	Tian Y, Teng LR, Song JJ, et al: Studies on the analgesic activities of Jia-Yuan-Qing pill and its safety evaluation in mice. Protoplasma. 251:1245–1253. 2014. View Article : Google Scholar : PubMed/NCBI
16	Lbarrola DA, Hellion-lbarrola MC, Montalbetti Y, et al: Isolation of hypotensive compounds from Solanum sisymbriifolium Lam. J Ethnopharmacol. 70:301–307. 2000. View Article : Google Scholar : PubMed/NCBI
17	Chinese Pharmacopoeia Commision (eds), . Pharmacopoeia Of The People's Republic Of China. Chinese Medical Science and Technology Press; Beijing, China: 2010
18	Gao L, Liu G, Kang J, et al: Paclitaxel nanosuspensions coated with P-gp inhibitory surfactants: I. Acute toxicity and pharmacokinetics studies. Colloids Surf B Biointerfaces. 111:277–281. 2013. View Article : Google Scholar : PubMed/NCBI
19	El Hilaly J, Israili ZH and Lyoussi B: Acute and chronic toxicological studies of Ajuga iva in experimental animals. J Ethnopharmacol. 91:43–50. 2004. View Article : Google Scholar : PubMed/NCBI
20	Wilson KG, Chochinov HM, McPherson CJ, et al: Suffering with advanced cancer. J Clin Oncol. 25:1691–1697. 2007. View Article : Google Scholar : PubMed/NCBI
21	Krishna LK, Poulose JV, Tan BS and Goh C: Opioid use amongst cancer patients at the end of life. Ann Acad Med Singap. 39:790–797. 2010.PubMed/NCBI
22	Bowdle TA: Adverse effects of opioid agonists and agonist-antagonists in anaesthesia. Drug Saf. 19:173–189. 1998. View Article : Google Scholar : PubMed/NCBI
23	Stiefel F, Die Trill M, Berney A, Olarte JM and Razavi A: Depression in palliative care: a pragmatic report from the Expert Working Group of the European Association for Palliative Care. Support Care Cancer. 9:477–488. 2001. View Article : Google Scholar : PubMed/NCBI
24	Lewis J, Mansour A, Khachaturian H, Watson SJ and Akil H: Opioids and pain regulation. Pain Headache. 9:129–159. 1987.PubMed/NCBI
25	Koob GF: Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology. 561:18–31. 2009. View Article : Google Scholar
26	Crews FT and Boettiger CA: Impulsivity, frontal lobes and risk for addiction. Pharmacol Biochem Behav. 93:237–247. 2009. View Article : Google Scholar : PubMed/NCBI
27	Williams JT, Ingram SL, Henderson G, et al: Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev. 65:223–254. 2013. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats

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