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Article

Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock

  • Authors:
    • Shu Chen
    • Jing‑Song Shi
    • Xiaokaiti Yibulayin
    • Tian‑Shan Wu
    • Xin‑Wen Yang
    • Jie Zhang
    • Paerhati Baiheti
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang 830000, P.R. China, Emergency Center, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang 830000, P.R. China
  • Pages: 237-240
    |
    Published online on: April 23, 2015
       https://doi.org/10.3892/etm.2015.2446
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Abstract

Patients with traumatic hemorrhagic shock are highly susceptible to the development of acute kidney injury (AKI), but little data are available regarding the changes in cystatin C (CysC) in patients with traumatic hemorrhagic shock. The aim of the present study, therefore, was to investigate whether cysC has a higher value than serum creatinine (SCr) and urea for use in monitoring glomerular function in traumatic hemorrhagic shock. Data from a cohort of patients with traumatic hemorrhagic shock, who had been admitted to a trauma center, were collected. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic value of serum CysC, SCr and urea for the identification of renal dysfunction, and the data were expressed as the area under the curve (AUC). CysC was not significantly affected by gender, age, mechanism of injury or time between injury and arrival at the center in the patients with traumatic hemorrhagic shock. The CysC level of the patients was significantly higher than that of the normal subjects (1.10±0.36 vs. 0.91±0.34 mg/l); the SCr and urea levels of the patients were also significantly increased compared with those of the normal subjects. Nonparametric ROC plots of the sensitivity and specificity of SCr, CysC and urea for the detection of AKI revealed AUC values of 0.901 [95% confidence interval (CI), 0.791‑1.000], 0.728 (95% CI, 0.570‑0.886) and 0.709 (95% CI, 0.552‑0.865) for SCr, CysC and urea, respectively. No significant correlation between mortality and cysC, SCr or urea was found. These data indicate that the level of CysC is significantly increased in the early stage of traumatic hemorrhagic shock and that CysC can be used as a marker to predict AKI; however, the diagnostic utility of CysC remains lower than that of SCr in the early stage of the condition.
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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Shi JS, Yibulayin X, Wu TS, Yang XW, Zhang J and Baiheti P: Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock. Exp Ther Med 10: 237-240, 2015.
APA
Chen, S., Shi, J., Yibulayin, X., Wu, T., Yang, X., Zhang, J., & Baiheti, P. (2015). Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock. Experimental and Therapeutic Medicine, 10, 237-240. https://doi.org/10.3892/etm.2015.2446
MLA
Chen, S., Shi, J., Yibulayin, X., Wu, T., Yang, X., Zhang, J., Baiheti, P."Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock". Experimental and Therapeutic Medicine 10.1 (2015): 237-240.
Chicago
Chen, S., Shi, J., Yibulayin, X., Wu, T., Yang, X., Zhang, J., Baiheti, P."Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock". Experimental and Therapeutic Medicine 10, no. 1 (2015): 237-240. https://doi.org/10.3892/etm.2015.2446
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Shi JS, Yibulayin X, Wu TS, Yang XW, Zhang J and Baiheti P: Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock. Exp Ther Med 10: 237-240, 2015.
APA
Chen, S., Shi, J., Yibulayin, X., Wu, T., Yang, X., Zhang, J., & Baiheti, P. (2015). Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock. Experimental and Therapeutic Medicine, 10, 237-240. https://doi.org/10.3892/etm.2015.2446
MLA
Chen, S., Shi, J., Yibulayin, X., Wu, T., Yang, X., Zhang, J., Baiheti, P."Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock". Experimental and Therapeutic Medicine 10.1 (2015): 237-240.
Chicago
Chen, S., Shi, J., Yibulayin, X., Wu, T., Yang, X., Zhang, J., Baiheti, P."Cystatin C is a moderate predictor of acute kidney injury in the early stage of traumatic hemorrhagic shock". Experimental and Therapeutic Medicine 10, no. 1 (2015): 237-240. https://doi.org/10.3892/etm.2015.2446
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