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Article

Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation

  • Authors:
    • Yueying Liu
    • Luer Bao
    • Liying Xuan
    • Baohua Song
    • Lin Lin
    • Hao Han
  • View Affiliations / Copyright

    Affiliations: Teaching and Research Section of Physiology and Pathophysiology, Medical College, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028041, P.R. China
  • Pages: 263-268
    |
    Published online on: April 23, 2015
       https://doi.org/10.3892/etm.2015.2447
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Abstract

Inflammatory response in the vasculature, including the overexpression of tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β, has been demonstrated to increase the risk of thrombosis development. Chebulagic acid (CA) is a key chemical component in the traditional Mongolian anti‑thrombotic drug Garidi‑13, and has been suggested to exert anti‑inflammatory and anti‑infective effects. The present study aimed to evaluate the regulatory impact of CA on a number of biological processes, including lipopolysaccharide (LPS)‑induced inflammation, LPS‑promoted mitogen‑activated protein kinase (MAPK) activation and the expression of toll‑like receptor (TLR)4 in EA.hy926 human endothelial cells. The results indicated that CA significantly inhibited the LPS‑induced upregulation of TNF‑α and IL‑1β in a dose‑ and time‑dependent manner. Furthermore, LPS‑activated MAPK signaling was inhibited by CA treatment in the EA.hy926 cells. However, TLR4, which serves a key function in LPS‑induced inflammation as the receptor of LPS, was not regulated by the CA treatment. In summary, the results of the present study indicate that CA inhibits the LPS‑induced promotion of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation, which may contribute to the anti‑thrombotic effect of Garidi‑13.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Bao L, Xuan L, Song B, Lin L and Han H: Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation. Exp Ther Med 10: 263-268, 2015.
APA
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., & Han, H. (2015). Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation. Experimental and Therapeutic Medicine, 10, 263-268. https://doi.org/10.3892/etm.2015.2447
MLA
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., Han, H."Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation". Experimental and Therapeutic Medicine 10.1 (2015): 263-268.
Chicago
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., Han, H."Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation". Experimental and Therapeutic Medicine 10, no. 1 (2015): 263-268. https://doi.org/10.3892/etm.2015.2447
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Bao L, Xuan L, Song B, Lin L and Han H: Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation. Exp Ther Med 10: 263-268, 2015.
APA
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., & Han, H. (2015). Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation. Experimental and Therapeutic Medicine, 10, 263-268. https://doi.org/10.3892/etm.2015.2447
MLA
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., Han, H."Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation". Experimental and Therapeutic Medicine 10.1 (2015): 263-268.
Chicago
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., Han, H."Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation". Experimental and Therapeutic Medicine 10, no. 1 (2015): 263-268. https://doi.org/10.3892/etm.2015.2447
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